Head injury, alpha-synuclein genetic variability and Parkinson’s disease
Identifieur interne : 001955 ( Ncbi/Merge ); précédent : 001954; suivant : 001956Head injury, alpha-synuclein genetic variability and Parkinson’s disease
Auteurs : Pei-Chen Lee [Taïwan] ; Yvette Bordelon [États-Unis] ; Jeff Bronstein [États-Unis] ; Janet S. Sinsheimer [États-Unis] ; Matthew Farrer [Canada] ; Beate Ritz [États-Unis]Source :
- European journal of neurology : the official journal of the European Federation of Neurological Societies [ 1351-5101 ] ; 2014.
Abstract
Head injury has been linked to Parkinson’s disease (PD) in some but not all studies. Differences in the genetic and environmental susceptibility to PD between populations might be one explanation. We investigate the joint effects of head injuries and
From 2001 to 2012, we enrolled 561 incident idiopathic PD cases and 721 population controls from central California. Subjects reported on head injuries throughout life-time and were assessed for genetic variability in the
PD risk in individuals with head injury who are carriers of at least one 263bp allele in D4S3481 or rs356165 variants was 3–4.5 fold higher compared with non-carriers without head injuries. However, tests for interaction between head injury and
Our study finds some evidence that head injury and D4S3481 or rs356165 variants jointly increase the risk of PD but little evidence of interaction.
Url:
DOI: 10.1111/ene.12585
PubMed: 25370538
PubMed Central: 4390403
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Head injury, alpha-synuclein genetic variability and Parkinson’s disease</title><author><name sortKey="Lee, Pei Chen" sort="Lee, Pei Chen" uniqKey="Lee P" first="Pei-Chen" last="Lee">Pei-Chen Lee</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Health Care Management, College of Healthcare Administration and Management, National Taipei University of Nursing Health Sciences, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Health Care Management, College of Healthcare Administration and Management, National Taipei University of Nursing Health Sciences</wicri:regionArea><wicri:noRegion>National Taipei University of Nursing Health Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Bordelon, Yvette" sort="Bordelon, Yvette" uniqKey="Bordelon Y" first="Yvette" last="Bordelon">Yvette Bordelon</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology, School of Medicine, University of California at Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, School of Medicine, University of California at Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology, School of Medicine, University of California at Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, School of Medicine, University of California at Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sinsheimer, Janet S" sort="Sinsheimer, Janet S" uniqKey="Sinsheimer J" first="Janet S." last="Sinsheimer">Janet S. Sinsheimer</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Human Genetics and Biomathematics, David Geffen School of Medicine at UCLA, and Department of Biostatistics, Fielding School of Public Health, University of California at Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics and Biomathematics, David Geffen School of Medicine at UCLA, and Department of Biostatistics, Fielding School of Public Health, University of California at Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Farrer, Matthew" sort="Farrer, Matthew" uniqKey="Farrer M" first="Matthew" last="Farrer">Matthew Farrer</name><affiliation wicri:level="1"><nlm:aff id="A4">Djavad Mowafaghian Centre for Brain Health, Department of Medical Genetics, University of British Columbia, Vancouver, Canada</nlm:aff><country 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type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25370538</idno><idno type="pmc">4390403</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390403</idno><idno type="RBID">PMC:4390403</idno><idno type="doi">10.1111/ene.12585</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000890</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000890</idno><idno 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Nursing Health Sciences</wicri:regionArea><wicri:noRegion>National Taipei University of Nursing Health Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Bordelon, Yvette" sort="Bordelon, Yvette" uniqKey="Bordelon Y" first="Yvette" last="Bordelon">Yvette Bordelon</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology, School of Medicine, University of California at Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, School of Medicine, University of California at Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology, School of Medicine, University of California at Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, School of Medicine, University of California at Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sinsheimer, Janet S" sort="Sinsheimer, Janet S" uniqKey="Sinsheimer J" first="Janet S." last="Sinsheimer">Janet S. Sinsheimer</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Human Genetics and Biomathematics, David Geffen School of Medicine at UCLA, and Department of Biostatistics, Fielding School of Public Health, University of California at Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics and Biomathematics, David Geffen School of Medicine at UCLA, and Department of Biostatistics, Fielding School of Public Health, University of California at Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Farrer, Matthew" sort="Farrer, Matthew" uniqKey="Farrer M" first="Matthew" last="Farrer">Matthew Farrer</name><affiliation wicri:level="1"><nlm:aff id="A4">Djavad Mowafaghian Centre for Brain Health, Department of Medical Genetics, University of British Columbia, Vancouver, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Djavad Mowafaghian Centre for Brain Health, Department of Medical Genetics, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Human Genetics and Biomathematics, David Geffen School of Medicine at UCLA, and Department of Biostatistics, Fielding School of Public Health, University of California at Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics and Biomathematics, David Geffen School of Medicine at UCLA, and Department of Biostatistics, Fielding School of Public Health, University of California at Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">European journal of neurology : the official journal of the European Federation of Neurological Societies</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Head injury has been linked to Parkinson’s disease (PD) in some but not all studies. Differences in the genetic and environmental susceptibility to PD between populations might be one explanation. We investigate the joint effects of head injuries and <italic>SNCA</italic> genetic variants.</p></sec><sec id="S2"><title>Methods</title><p id="P2">From 2001 to 2012, we enrolled 561 incident idiopathic PD cases and 721 population controls from central California. Subjects reported on head injuries throughout life-time and were assessed for genetic variability in the <italic>SNCA</italic> 5′ region (D4S3481; Rep1) and 3′ UTR (rs356165). In unconditional logistic regression models adjusted for confounders, we tested for interactions between head injuries and genetic risk variants.</p></sec><sec id="S3"><title>Results</title><p id="P3">PD risk in individuals with head injury who are carriers of at least one 263bp allele in D4S3481 or rs356165 variants was 3–4.5 fold higher compared with non-carriers without head injuries. However, tests for interaction between head injury and <italic>SNCA</italic> D4S3481or rs356165 were not statistically significant.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Our study finds some evidence that head injury and D4S3481 or rs356165 variants jointly increase the risk of PD but little evidence of interaction.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9506311</journal-id><journal-id journal-id-type="pubmed-jr-id">20870</journal-id><journal-id journal-id-type="nlm-ta">Eur J Neurol</journal-id><journal-id journal-id-type="iso-abbrev">Eur. J. Neurol.</journal-id><journal-title-group><journal-title>European journal of neurology : the official journal of the European Federation of Neurological Societies</journal-title></journal-title-group><issn pub-type="ppub">1351-5101</issn><issn pub-type="epub">1468-1331</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25370538</article-id><article-id pub-id-type="pmc">4390403</article-id><article-id pub-id-type="doi">10.1111/ene.12585</article-id><article-id pub-id-type="manuscript">NIHMS626591</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Head injury, alpha-synuclein genetic variability and Parkinson’s disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Pei-Chen</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bordelon</surname><given-names>Yvette</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Bronstein</surname><given-names>Jeff</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Sinsheimer</surname><given-names>Janet S.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Farrer</surname><given-names>Matthew</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Ritz</surname><given-names>Beate</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A5">5</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Health Care Management, College of Healthcare Administration and Management, National Taipei University of Nursing Health Sciences, Taiwan</aff><aff id="A2"><label>2</label>Department of Neurology, School of Medicine, University of California at Los Angeles, California, USA</aff><aff id="A3"><label>3</label>Department of Human Genetics and Biomathematics, David Geffen School of Medicine at UCLA, and Department of Biostatistics, Fielding School of Public Health, University of California at Los Angeles, California, USA</aff><aff id="A4"><label>4</label>Djavad Mowafaghian Centre for Brain Health, Department of Medical Genetics, University of British Columbia, Vancouver, Canada</aff><aff id="A5"><label>5</label>Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, California, USA</aff><author-notes><corresp id="cor1"><bold>Correspondence:</bold> Address correspondence to Beate Ritz, Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, Los Angeles, California, USA, 650 Charles E. Young Drive, Los Angeles, CA 90095-1772, USA; tel (310) 206 7458; fax (310) 206 6039; <email>britz@ucla.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>10</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>05</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2016</year></pub-date><volume>22</volume><issue>5</issue><fpage>874</fpage><lpage>878</lpage><pmc-comment>elocation-id from pubmed: 10.1111/ene.12585</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">Head injury has been linked to Parkinson’s disease (PD) in some but not all studies. Differences in the genetic and environmental susceptibility to PD between populations might be one explanation. We investigate the joint effects of head injuries and <italic>SNCA</italic> genetic variants.</p></sec><sec id="S2"><title>Methods</title><p id="P2">From 2001 to 2012, we enrolled 561 incident idiopathic PD cases and 721 population controls from central California. Subjects reported on head injuries throughout life-time and were assessed for genetic variability in the <italic>SNCA</italic> 5′ region (D4S3481; Rep1) and 3′ UTR (rs356165). In unconditional logistic regression models adjusted for confounders, we tested for interactions between head injuries and genetic risk variants.</p></sec><sec id="S3"><title>Results</title><p id="P3">PD risk in individuals with head injury who are carriers of at least one 263bp allele in D4S3481 or rs356165 variants was 3–4.5 fold higher compared with non-carriers without head injuries. However, tests for interaction between head injury and <italic>SNCA</italic> D4S3481or rs356165 were not statistically significant.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Our study finds some evidence that head injury and D4S3481 or rs356165 variants jointly increase the risk of PD but little evidence of interaction.</p></sec></abstract><kwd-group><kwd>Parkinson’s disease</kwd><kwd>gene-environment interaction</kwd><kwd>head injury</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Canada</li><li>Taïwan</li><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="Taïwan"><noRegion><name sortKey="Lee, Pei Chen" sort="Lee, Pei Chen" uniqKey="Lee P" first="Pei-Chen" last="Lee">Pei-Chen Lee</name></noRegion></country><country name="États-Unis"><region name="Californie"><name sortKey="Bordelon, Yvette" sort="Bordelon, Yvette" uniqKey="Bordelon Y" first="Yvette" last="Bordelon">Yvette Bordelon</name></region><name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name><name sortKey="Sinsheimer, Janet S" sort="Sinsheimer, Janet S" uniqKey="Sinsheimer J" first="Janet S." last="Sinsheimer">Janet S. Sinsheimer</name></country><country name="Canada"><noRegion><name sortKey="Farrer, Matthew" sort="Farrer, Matthew" uniqKey="Farrer M" first="Matthew" last="Farrer">Matthew Farrer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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