La maladie de Parkinson au Canada (serveur d'exploration)

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A review of methods used to study cognitive deficits in Parkinson's disease.

Identifieur interne : 001356 ( Ncbi/Merge ); précédent : 001355; suivant : 001357

A review of methods used to study cognitive deficits in Parkinson's disease.

Auteurs : Abdul Qayyum Rana [Canada] ; Mohamed Sufian Masroor ; Atif Saeed Khan

Source :

RBID : pubmed:23317792

English descriptors

Abstract

In addition to the classic motor symptoms of Parkinson's disease (PD), some patients suffer from a variety of non-motor symptoms. Cognitive deficits such as impairments to learning and memory have been noted in PD and pose a clinical concern. However, during early stages of the disease these deficits may be subtle and difficult to diagnose. To date, various methodologies have been used to identify and diagnose these impairments in PD; imaging studies, animal models, and computer simulated learning paradigms being the most popular. This review discusses the advantages and disadvantages of each method in studying cognitive deficits associated with PD.

DOI: 10.1179/1743132812Y.0000000118
PubMed: 23317792

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pubmed:23317792

Le document en format XML

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<div type="abstract" xml:lang="en">In addition to the classic motor symptoms of Parkinson's disease (PD), some patients suffer from a variety of non-motor symptoms. Cognitive deficits such as impairments to learning and memory have been noted in PD and pose a clinical concern. However, during early stages of the disease these deficits may be subtle and difficult to diagnose. To date, various methodologies have been used to identify and diagnose these impairments in PD; imaging studies, animal models, and computer simulated learning paradigms being the most popular. This review discusses the advantages and disadvantages of each method in studying cognitive deficits associated with PD.</div>
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<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">In addition to the classic motor symptoms of Parkinson's disease (PD), some patients suffer from a variety of non-motor symptoms. Cognitive deficits such as impairments to learning and memory have been noted in PD and pose a clinical concern. However, during early stages of the disease these deficits may be subtle and difficult to diagnose. To date, various methodologies have been used to identify and diagnose these impairments in PD; imaging studies, animal models, and computer simulated learning paradigms being the most popular. This review discusses the advantages and disadvantages of each method in studying cognitive deficits associated with PD.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Imaging studies, including PET and magnetic resonance imaging scans, are useful when studying neural correlates of cognitive tasks. In contrast, toxin-induced and transgenic animal models are well suited for modelling physiological and behavioural conditions observed in humans. Computer simulated learning paradigms are used to analyze cognitive functioning when one engages in a cognitive task.</AbstractText>
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   |clé=     pubmed:23317792
   |texte=   A review of methods used to study cognitive deficits in Parkinson's disease.
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