The association between parkinsonism, Alzheimer's disease, and mortality: a comprehensive approach.
Identifieur interne : 000097 ( Ncbi/Merge ); précédent : 000096; suivant : 000098The association between parkinsonism, Alzheimer's disease, and mortality: a comprehensive approach.
Auteurs : S L Mitchell [Canada] ; K. RockwoodSource :
- Journal of the American Geriatrics Society [ 0002-8614 ] ; 2000.
Descripteurs français
- Wicri :
- geographic : Canada.
English descriptors
- KwdEn :
- MESH :
- geographic : Canada.
- complications : Alzheimer Disease, Dementia, Parkinson Disease.
- diagnosis : Alzheimer Disease.
- mortality : Parkinson Disease.
- Aged, Aged, 80 and over, Cohort Studies, Follow-Up Studies, Gait, Humans, Risk Factors, Survival Analysis.
Abstract
The impact of parkinsonism on survival in older persons independent of dementia is not well understood.
PubMed: 10798470
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Rockwood</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10798470</idno><idno type="pmid">10798470</idno><idno type="wicri:Area/PubMed/Corpus">001653</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001653</idno><idno type="wicri:Area/PubMed/Curation">001653</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001653</idno><idno type="wicri:Area/PubMed/Checkpoint">001653</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001653</idno><idno type="wicri:Area/Ncbi/Merge">000097</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The association between parkinsonism, Alzheimer's disease, and mortality: a comprehensive approach.</title><author><name sortKey="Mitchell, S L" sort="Mitchell, S L" uniqKey="Mitchell S" first="S L" last="Mitchell">S L Mitchell</name><affiliation wicri:level="1"><nlm:affiliation>Division of Geriatric Medicine, Loeb Health Research Institute, the Ottawa Hospital and the University of Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Geriatric Medicine, Loeb Health Research Institute, the Ottawa Hospital and the University of Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Rockwood, K" sort="Rockwood, K" uniqKey="Rockwood K" first="K" last="Rockwood">K. Rockwood</name></author></analytic><series><title level="j">Journal of the American Geriatrics Society</title><idno type="ISSN">0002-8614</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alzheimer Disease (complications)</term><term>Alzheimer Disease (diagnosis)</term><term>Canada</term><term>Cohort Studies</term><term>Dementia (complications)</term><term>Follow-Up Studies</term><term>Gait</term><term>Humans</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (mortality)</term><term>Risk Factors</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Canada</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Alzheimer Disease</term><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Follow-Up Studies</term><term>Gait</term><term>Humans</term><term>Risk Factors</term><term>Survival Analysis</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Canada</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The impact of parkinsonism on survival in older persons independent of dementia is not well understood.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10798470</PMID><DateCreated><Year>2000</Year><Month>05</Month><Day>18</Day></DateCreated><DateCompleted><Year>2000</Year><Month>05</Month><Day>18</Day></DateCompleted><DateRevised><Year>2008</Year><Month>03</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-8614</ISSN><JournalIssue CitedMedium="Print"><Volume>48</Volume><Issue>4</Issue><PubDate><Year>2000</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Journal of the American Geriatrics Society</Title><ISOAbbreviation>J Am Geriatr Soc</ISOAbbreviation></Journal><ArticleTitle>The association between parkinsonism, Alzheimer's disease, and mortality: a comprehensive approach.</ArticleTitle><Pagination><MedlinePgn>422-5</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The impact of parkinsonism on survival in older persons independent of dementia is not well understood.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Participants in the clinical examination of the Canadian Study of Health and Aging who had parkinsonism and were older than age 65 were identified. The impact of parkinsonism on 5-year survival was determined for a combined cohort with and without dementia, and a stratified analysis was then conducted for the subgroups with Alzheimer's disease (AD) and those without dementia. Subjects with a previous diagnosis of Parkinson's disease and those prescribed drugs causing extrapyramidal side effects were excluded.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">A total of 721 subjects with AD and 1705 subjects without dementia were examined. After adjusting for age and residential status (community vs institution), parkinsonism was associated with poorer survival in the combined cohort (risk ratio 1.51; 95% CI, 1.22-1.85), in those with AD (risk ratio 1.34; 95% CI, 1.02-1.76), and those without dementia (risk ratio 1.54; 95% CI, 1.11-2.15). In the combined cohort, parkinsonism remained independently associated with higher mortality after adjusting for AD status (risk ratio 1.39; 95% CI, 1.13-1.72). In the subgroup with AD, parkinsonism remained associated with poorer survival after adjusting for severity of cognitive impairment (risk ratio 1.33; 95% CI. 1.04-1.74).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Parkinsonism is significantly associated with poorer survival in older persons, regardless of whether they have dementia.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mitchell</LastName><ForeName>S L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Division of Geriatric Medicine, Loeb Health Research Institute, the Ottawa Hospital and the University of Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rockwood</LastName><ForeName>K</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Am Geriatr Soc</MedlineTA><NlmUniqueID>7503062</NlmUniqueID><ISSNLinking>0002-8614</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000544" MajorTopicYN="N">Alzheimer Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N" Type="Geographic">Canada</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003704" MajorTopicYN="N">Dementia</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005684" MajorTopicYN="N">Gait</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>5</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2000</Year><Month>5</Month><Day>20</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>5</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10798470</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Rockwood, K" sort="Rockwood, K" uniqKey="Rockwood K" first="K" last="Rockwood">K. Rockwood</name></noCountry><country name="Canada"><noRegion><name sortKey="Mitchell, S L" sort="Mitchell, S L" uniqKey="Mitchell S" first="S L" last="Mitchell">S L Mitchell</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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