Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line--derived neurotrophic factor in patients with Parkinson's disease. Report of two cases and technical considerations.
Identifieur interne : 000096 ( Ncbi/Merge ); précédent : 000095; suivant : 000097Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line--derived neurotrophic factor in patients with Parkinson's disease. Report of two cases and technical considerations.
Auteurs : I. Mendez [Canada] ; A. Dagher ; M. Hong ; A. Hebb ; P. Gaudet ; A. Law ; S. Weerasinghe ; D. King ; J. Desrosiers ; S. Darvesh ; T. Acorn ; H. RobertsonSource :
- Journal of neurosurgery [ 0022-3085 ] ; 2000.
English descriptors
- KwdEn :
- Aged, Brain Tissue Transplantation (pathology), Cell Count, Cell Line, Cell Survival, Dihydroxyphenylalanine (analogs & derivatives), Dopamine (secretion), Feasibility Studies, Fetal Tissue Transplantation (pathology), Fluorine Radioisotopes, Follow-Up Studies, Graft Survival, Humans, Male, Mesencephalon (cytology), Mesencephalon (drug effects), Mesencephalon (embryology), Middle Aged, Nerve Growth Factor (therapeutic use), Neuroglia, Parkinson Disease (surgery), Putamen (surgery), Radiopharmaceuticals, Substantia Nigra (cytology), Substantia Nigra (drug effects), Substantia Nigra (embryology), Substantia Nigra (transplantation), Tissue Preservation, Tomography, Emission-Computed, Treatment Outcome, Tyrosine 3-Monooxygenase (analysis).
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , analysis : Tyrosine 3-Monooxygenase.
- cytology : Mesencephalon, Substantia Nigra.
- drug effects : Mesencephalon, Substantia Nigra.
- embryology : Mesencephalon, Substantia Nigra.
- pathology : Brain Tissue Transplantation, Fetal Tissue Transplantation.
- chemical , secretion : Dopamine.
- surgery : Parkinson Disease, Putamen.
- chemical , therapeutic use : Nerve Growth Factor.
- transplantation : Substantia Nigra.
- Aged, Cell Count, Cell Line, Cell Survival, Feasibility Studies, Fluorine Radioisotopes, Follow-Up Studies, Graft Survival, Humans, Male, Middle Aged, Neuroglia, Radiopharmaceuticals, Tissue Preservation, Tomography, Emission-Computed, Treatment Outcome.
Abstract
The authors have studied the ability of glial cell line-derived neurotrophic factor (GDNF) to promote survival of human fetal dopaminergic tissue after a storage period of 6 days and subsequent implantation into the human putamen. The results indicate that GDNF promotes survival of stored dopaminergic cells. Cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Two patients with Parkinson's disease received bilateral putaminal implants of fetal dopaminergic cells exposed to GDNF for 6 days and showed enhancement of graft survival as assessed by positron emission tomography scanning. A mean increase of 107% in putaminal fluorodopa uptake from baseline values was observed 12 months postgrafting.
DOI: 10.3171/jns.2000.92.5.0863
PubMed: 10794303
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001643
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pubmed:10794303Le document en format XML
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<term>Tomography, Emission-Computed</term>
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<front><div type="abstract" xml:lang="en">The authors have studied the ability of glial cell line-derived neurotrophic factor (GDNF) to promote survival of human fetal dopaminergic tissue after a storage period of 6 days and subsequent implantation into the human putamen. The results indicate that GDNF promotes survival of stored dopaminergic cells. Cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Two patients with Parkinson's disease received bilateral putaminal implants of fetal dopaminergic cells exposed to GDNF for 6 days and showed enhancement of graft survival as assessed by positron emission tomography scanning. A mean increase of 107% in putaminal fluorodopa uptake from baseline values was observed 12 months postgrafting.</div>
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<Abstract><AbstractText>The authors have studied the ability of glial cell line-derived neurotrophic factor (GDNF) to promote survival of human fetal dopaminergic tissue after a storage period of 6 days and subsequent implantation into the human putamen. The results indicate that GDNF promotes survival of stored dopaminergic cells. Cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Two patients with Parkinson's disease received bilateral putaminal implants of fetal dopaminergic cells exposed to GDNF for 6 days and showed enhancement of graft survival as assessed by positron emission tomography scanning. A mean increase of 107% in putaminal fluorodopa uptake from baseline values was observed 12 months postgrafting.</AbstractText>
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