α-Synuclein and Lewy pathology in Parkinson's disease.
Identifieur interne : 001C21 ( Ncbi/Curation ); précédent : 001C20; suivant : 001C22α-Synuclein and Lewy pathology in Parkinson's disease.
Auteurs : Lorraine V. Kalia [Canada] ; Suneil K. KaliaSource :
- Current opinion in neurology [ 1473-6551 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : alpha-Synuclein.
- metabolism : Brain, Neurons, Parkinson Disease.
- pathology : Brain, Lewy Bodies, Neurons, Parkinson Disease.
- Humans.
Abstract
The role of protein aggregates, such as Lewy body inclusions, in the molecular pathogenesis of Parkinson's disease has remained controversial and elusive. The protein α-synuclein is a major component of these inclusions but it can exist in many alternate conformations. Here we review advances in our understanding of the roles of Lewy pathology and α-synuclein in Parkinson's disease.
DOI: 10.1097/WCO.0000000000000215
PubMed: 26110807
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pubmed:26110807Le document en format XML
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<term>Parkinson Disease (metabolism)</term>
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<front><div type="abstract" xml:lang="en">The role of protein aggregates, such as Lewy body inclusions, in the molecular pathogenesis of Parkinson's disease has remained controversial and elusive. The protein α-synuclein is a major component of these inclusions but it can exist in many alternate conformations. Here we review advances in our understanding of the roles of Lewy pathology and α-synuclein in Parkinson's disease.</div>
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