Pain perception in acute model mice of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Identifieur interne : 000445 ( PubMed/Checkpoint ); précédent : 000444; suivant : 000446Pain perception in acute model mice of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Auteurs : Jihye Park [Corée du Sud] ; Chae-Seok Lim [Corée du Sud] ; Hyunhyo Seo [Corée du Sud] ; Chung-Ah Park [Corée du Sud] ; Min Zhuo [Canada] ; Bong-Kiun Kaang [Corée du Sud] ; Kyungmin Lee [Corée du Sud]Source :
- Molecular pain [ 1744-8069 ] ; 2015.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology), Animals, Astrocytes (drug effects), Corpus Striatum (drug effects), Disease Models, Animal, Dopamine (metabolism), Male, Mice, Mice, Inbred C57BL, Microglia (drug effects), Microglia (metabolism), Motor Activity (drug effects), Neurons (drug effects), Neurons (metabolism), Pain Perception (drug effects), Parkinson Disease.
- MESH :
- chemical , metabolism : Dopamine.
- chemical , pharmacology : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- drug effects : Astrocytes, Corpus Striatum, Microglia, Motor Activity, Neurons, Pain Perception.
- metabolism : Microglia, Neurons.
- Animals, Disease Models, Animal, Male, Mice, Mice, Inbred C57BL, Parkinson Disease.
Abstract
Pain is the most prominent non-motor symptom observed in patients with Parkinson's disease (PD). However, the mechanisms underlying the generation of pain in PD have not been well studied. We used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD to analyze the relationship between pain sensory abnormalities and the degeneration of dopaminergic neurons.
DOI: 10.1186/s12990-015-0026-1
PubMed: 25981600
Affiliations:
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Lim</name><affiliation wicri:level="4"><nlm:affiliation>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747, South Korea. cslim@snu.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747</wicri:regionArea><orgName type="university">Université nationale de Séoul</orgName><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Seo, Hyunhyo" sort="Seo, Hyunhyo" uniqKey="Seo H" first="Hyunhyo" last="Seo">Hyunhyo Seo</name><affiliation wicri:level="1"><nlm:affiliation>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842, South Korea. hseo@knu.ac.kr.</nlm:affiliation><country 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University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842</wicri:regionArea><wicri:noRegion>700-842</wicri:noRegion></affiliation></author><author><name sortKey="Zhuo, Min" sort="Zhuo, Min" uniqKey="Zhuo M" first="Min" last="Zhuo">Min Zhuo</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physiology, Faculty of Medicine, University of Toronto, The center for the study of pain, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. minzhuo10@gmail.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology, Faculty of Medicine, University of Toronto, The center for the study of pain, 1 King's College Circle, Toronto, ON, M5S 1A8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kaang, Bong Kiun" sort="Kaang, Bong Kiun" uniqKey="Kaang B" first="Bong-Kiun" last="Kaang">Bong-Kiun Kaang</name><affiliation wicri:level="4"><nlm:affiliation>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747, South Korea. kaang@snu.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747</wicri:regionArea><orgName type="university">Université nationale de Séoul</orgName><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Kyungmin" sort="Lee, Kyungmin" uniqKey="Lee K" first="Kyungmin" last="Lee">Kyungmin Lee</name><affiliation wicri:level="1"><nlm:affiliation>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842, South Korea. irislkm@knu.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842</wicri:regionArea><wicri:noRegion>700-842</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25981600</idno><idno type="pmid">25981600</idno><idno type="doi">10.1186/s12990-015-0026-1</idno><idno type="wicri:Area/PubMed/Corpus">000498</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000498</idno><idno type="wicri:Area/PubMed/Curation">000498</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000498</idno><idno 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type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lim, Chae Seok" sort="Lim, Chae Seok" uniqKey="Lim C" first="Chae-Seok" last="Lim">Chae-Seok Lim</name><affiliation wicri:level="4"><nlm:affiliation>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747, South Korea. cslim@snu.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747</wicri:regionArea><orgName type="university">Université nationale de Séoul</orgName><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Seo, Hyunhyo" sort="Seo, Hyunhyo" uniqKey="Seo H" first="Hyunhyo" last="Seo">Hyunhyo Seo</name><affiliation wicri:level="1"><nlm:affiliation>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842, South Korea. hseo@knu.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842</wicri:regionArea><wicri:noRegion>700-842</wicri:noRegion></affiliation></author><author><name sortKey="Park, Chung Ah" sort="Park, Chung Ah" uniqKey="Park C" first="Chung-Ah" last="Park">Chung-Ah Park</name><affiliation wicri:level="1"><nlm:affiliation>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842, South Korea. pca2477@naver.com.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842</wicri:regionArea><wicri:noRegion>700-842</wicri:noRegion></affiliation></author><author><name sortKey="Zhuo, Min" sort="Zhuo, Min" uniqKey="Zhuo M" first="Min" last="Zhuo">Min Zhuo</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physiology, Faculty of Medicine, University of Toronto, The center for the study of pain, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. minzhuo10@gmail.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology, Faculty of Medicine, University of Toronto, The center for the study of pain, 1 King's College Circle, Toronto, ON, M5S 1A8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kaang, Bong Kiun" sort="Kaang, Bong Kiun" uniqKey="Kaang B" first="Bong-Kiun" last="Kaang">Bong-Kiun Kaang</name><affiliation wicri:level="4"><nlm:affiliation>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747, South Korea. kaang@snu.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747</wicri:regionArea><orgName type="university">Université nationale de Séoul</orgName><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Kyungmin" sort="Lee, Kyungmin" uniqKey="Lee K" first="Kyungmin" last="Lee">Kyungmin Lee</name><affiliation wicri:level="1"><nlm:affiliation>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842, South Korea. irislkm@knu.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842</wicri:regionArea><wicri:noRegion>700-842</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular pain</title><idno type="eISSN">1744-8069</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology)</term><term>Animals</term><term>Astrocytes (drug effects)</term><term>Corpus Striatum (drug effects)</term><term>Disease Models, Animal</term><term>Dopamine (metabolism)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Microglia (drug effects)</term><term>Microglia (metabolism)</term><term>Motor Activity (drug effects)</term><term>Neurons (drug effects)</term><term>Neurons (metabolism)</term><term>Pain Perception (drug effects)</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Astrocytes</term><term>Corpus Striatum</term><term>Microglia</term><term>Motor Activity</term><term>Neurons</term><term>Pain Perception</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Microglia</term><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Parkinson Disease</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pain is the most prominent non-motor symptom observed in patients with Parkinson's disease (PD). However, the mechanisms underlying the generation of pain in PD have not been well studied. We used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD to analyze the relationship between pain sensory abnormalities and the degeneration of dopaminergic neurons.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25981600</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>30</Day></DateCreated><DateCompleted><Year>2016</Year><Month>02</Month><Day>22</Day></DateCompleted><DateRevised><Year>2015</Year><Month>06</Month><Day>01</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1744-8069</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><PubDate><Year>2015</Year><Month>May</Month><Day>17</Day></PubDate></JournalIssue><Title>Molecular pain</Title><ISOAbbreviation>Mol Pain</ISOAbbreviation></Journal><ArticleTitle>Pain perception in acute model mice of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).</ArticleTitle><Pagination><MedlinePgn>28</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12990-015-0026-1</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Pain is the most prominent non-motor symptom observed in patients with Parkinson's disease (PD). However, the mechanisms underlying the generation of pain in PD have not been well studied. We used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD to analyze the relationship between pain sensory abnormalities and the degeneration of dopaminergic neurons.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The latency to fall off the rotarod and the total distance traveled in round chamber were significantly reduced in MPTP-induced PD mice, consistent with motor dysfunction. MPTP-treated mice also showed remarkably shorter nociceptive response latencies compared to saline-treated mice and the subcutaneous injection of L-3,4-dihydroxyphenylalanine (L-DOPA) partially reversed pain hypersensitivity induced by MPTP treatment. We found that degeneration of cell bodies and fibers in the substantia nigra pars compacta and the striatum of MPTP-treated mice. In addition, astrocytic and microglial activation was seen in the subthalamic nucleus and neuronal activity was significantly increased in the striatum and globus pallidus. However, we did not observe any changes in neurons, astrocytes, and microglia of both the dorsal and ventral horns in the spinal cord after MPTP treatment.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results suggest that the dopaminergic nigrostriatal pathway may have a role in inhibiting noxious stimuli, and that abnormal inflammatory responses and neural activity in basal ganglia is correlated to pain processing in PD induced by MPTP treatment.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Jihye</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747, South Korea. wizbella@snu.ac.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Chae-Seok</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747, South Korea. cslim@snu.ac.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seo</LastName><ForeName>Hyunhyo</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842, South Korea. hseo@knu.ac.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Chung-Ah</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842, South Korea. pca2477@naver.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhuo</LastName><ForeName>Min</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Physiology, Faculty of Medicine, University of Toronto, The center for the study of pain, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. minzhuo10@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaang</LastName><ForeName>Bong-Kiun</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747, South Korea. kaang@snu.ac.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Kyungmin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842, South Korea. irislkm@knu.ac.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Pain</MedlineTA><NlmUniqueID>101242662</NlmUniqueID><ISSNLinking>1744-8069</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>9P21XSP91P</RegistryNumber><NameOfSubstance UI="D015632">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</NameOfSubstance></Chemical><Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber><NameOfSubstance UI="D004298">Dopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nat Protoc. 2007;2(1):141-51</RefSource><PMID Version="1">17401348</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Chem Neuroanat. 2012 Jul;44(2):76-85</RefSource><PMID Version="1">22580273</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res. 2000 Feb 14;855(2):260-6</RefSource><PMID Version="1">10677598</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2000 Apr;6(4):470-3</RefSource><PMID Version="1">10742158</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurophysiol. 2000 Oct;84(4):1719-25</RefSource><PMID Version="1">11024064</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 2001 Apr 27;303(1):9-12</RefSource><PMID Version="1">11297811</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 2001;106(3):589-601</RefSource><PMID Version="1">11591459</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Brain Res. 2001 Nov 1;125(1-2):109-25</RefSource><PMID Version="1">11682102</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Prog Neurobiol. 2002 May;67(1):53-83</RefSource><PMID Version="1">12126656</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2003 Nov 13;349(20):1925-34</RefSource><PMID Version="1">14614167</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pain. 2004 Jul;110(1-2):246-9</RefSource><PMID Version="1">15275774</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Pharmacol. 2004 Oct 1;500(1-3):187-92</RefSource><PMID Version="1">15464032</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 1983 Feb;46(2):145-51</RefSource><PMID Version="1">6842218</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Chem Neuropathol. 1989 Jun;10(3):171-83</RefSource><PMID Version="1">2669769</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pharmacol Toxicol. 1992 Jan;70(1):31-7</RefSource><PMID Version="1">1594532</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropharmacology. 1993 Jul;32(7):633-40</RefSource><PMID Version="1">7689707</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mamm Genome. 2010 Feb;21(1-2):13-27</RefSource><PMID Version="1">20033184</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurotherapeutics. 2010 Oct;7(4):494-506</RefSource><PMID Version="1">20880511</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Free Radic Res. 2010 Nov;44(11):1304-16</RefSource><PMID Version="1">20815783</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pain. 2009 Jan;141(1-2):173-7</RefSource><PMID Version="1">19100686</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2008 Sep;9(9):665-77</RefSource><PMID Version="1">18714325</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2009 Jul;10(7):519-29</RefSource><PMID Version="1">19513088</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Physiol Behav. 2009 Aug 4;98(1-2):130-8</RefSource><PMID Version="1">19410592</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pain. 1995 Jan;60(1):3-38</RefSource><PMID Version="1">7715939</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Neurosci. 1996 Oct;19(10):417-22</RefSource><PMID Version="1">8888518</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci Methods. 1998 Sep 1;83(2):165-75</RefSource><PMID Version="1">9765130</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 1999 Oct;46(4):598-605</RefSource><PMID Version="1">10514096</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gend Med. 2005 Sep;2(3):137-45</RefSource><PMID Version="1">16290886</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2006 Mar;5(3):235-45</RefSource><PMID Version="1">16488379</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pain. 2012 Nov;153(11):2267-73</RefSource><PMID Version="1">22964434</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E746-55</RefSource><PMID Version="1">23386718</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Neurosci. 2013 May;37(10):1550-63</RefSource><PMID Version="1">23461676</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Brain. 2014;7:27</RefSource><PMID Version="1">24708859</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2014 Jun;20(6):662-4</RefSource><PMID Version="1">24685343</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Brain. 2014;7:47</RefSource><PMID Version="1">24935250</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Brain. 2014;7:76</RefSource><PMID Version="1">25359681</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Brain. 2014;7:72</RefSource><PMID Version="1">25277376</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res. 2008 Jun 5;1213:41-7</RefSource><PMID Version="1">18456244</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Res. 2008 Dec;62(4):246-53</RefSource><PMID Version="1">18824050</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Neurosci. 2010 Nov;120(11):717-23</RefSource><PMID Version="1">20942586</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Pain. 2010;6:75</RefSource><PMID Version="1">21050459</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2011 Jan;26(1):6-17</RefSource><PMID Version="1">21322014</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Pain. 2011;7:97</RefSource><PMID Version="1">22171983</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Psychiatry. 2000 Jan;5(1):14-21</RefSource><PMID Version="1">10673764</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D015632" MajorTopicYN="N">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001253" MajorTopicYN="N">Astrocytes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003342" MajorTopicYN="N">Corpus Striatum</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004298" MajorTopicYN="N">Dopamine</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017628" MajorTopicYN="N">Microglia</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009043" MajorTopicYN="N">Motor Activity</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058748" MajorTopicYN="N">Pain Perception</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="Y">Parkinson Disease</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4448854</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>01</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>05</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>5</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25981600</ArticleId><ArticleId IdType="doi">10.1186/s12990-015-0026-1</ArticleId><ArticleId IdType="pii">10.1186/s12990-015-0026-1</ArticleId><ArticleId IdType="pmc">PMC4448854</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li><li>Corée du Sud</li></country><region><li>Ontario</li></region><settlement><li>Séoul</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li><li>Université nationale de Séoul</li></orgName></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Park, Jihye" sort="Park, Jihye" uniqKey="Park J" first="Jihye" last="Park">Jihye Park</name></noRegion><name sortKey="Kaang, Bong Kiun" sort="Kaang, Bong Kiun" uniqKey="Kaang B" first="Bong-Kiun" last="Kaang">Bong-Kiun Kaang</name><name sortKey="Lee, Kyungmin" sort="Lee, Kyungmin" uniqKey="Lee K" first="Kyungmin" last="Lee">Kyungmin Lee</name><name sortKey="Lim, Chae Seok" sort="Lim, Chae Seok" uniqKey="Lim C" first="Chae-Seok" last="Lim">Chae-Seok Lim</name><name sortKey="Park, Chung Ah" sort="Park, Chung Ah" uniqKey="Park C" first="Chung-Ah" last="Park">Chung-Ah Park</name><name sortKey="Seo, Hyunhyo" sort="Seo, Hyunhyo" uniqKey="Seo H" first="Hyunhyo" last="Seo">Hyunhyo Seo</name></country><country name="Canada"><region name="Ontario"><name sortKey="Zhuo, Min" sort="Zhuo, Min" uniqKey="Zhuo M" first="Min" last="Zhuo">Min Zhuo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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