ParkinsonCanadaV1, Ncbi, Curation, bibRecord, 001971

Androgen Modulation of Hippocampal Structure and Function

Identifieur interne : 001971 ( Ncbi/Curation ); précédent : 001970; suivant : 001972

Androgen Modulation of Hippocampal Structure and Function

Auteurs : Sarah Atwi [Canada] ; Dallan Mcmahon [Canada] ; Helen Scharfman [États-Unis] ; Neil J. Maclusky [Canada]

Source :

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry [ 1073-8584 ] ; 2014.

RBID : PMC:5002217

Abstract

Androgens have profound effects on hippocampal structure and function, including induction of spines and spine synapses on the dendrites of CA1 pyramidal neurons, as well as alterations in long-term synaptic plasticity (LTP) and hippocampally dependent cognitive behaviors. How these effects occur remains largely unknown. Emerging evidence, however, suggests that one of the key elements in the response mechanism may be modulation of brain-derived neurotrophic factor (BDNF) in the mossy fiber (MF) system. In male rats, orchidectomy increases synaptic transmission and excitability in the MF pathway. Testosterone reverses these effects, suggesting that testosterone exerts tonic suppression on MF BDNF levels. These findings suggest that changes in hippocampal function resulting from declining androgen levels may reflect the outcome of responses mediated through normally balanced, but opposing, mechanisms: loss of androgen effects on the hippocampal circuitry may be compensated, at least in part, by an increase in BDNF-dependent MF plasticity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002217

DOI: 10.1177/1073858414558065
PubMed: 25416742
PubMed Central: 5002217

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PMC:5002217

Le document en format XML

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Androgen Modulation of Hippocampal Structure and Function

Androgen Modulation of Hippocampal Structure and Function

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki