Androgen Modulation of Hippocampal Structure and Function
Identifieur interne : 000888 ( Pmc/Corpus ); précédent : 000887; suivant : 000889Androgen Modulation of Hippocampal Structure and Function
Auteurs : Sarah Atwi ; Dallan Mcmahon ; Helen Scharfman ; Neil J. MacluskySource :
- The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry [ 1073-8584 ] ; 2014.
Abstract
Androgens have profound effects on hippocampal structure and function, including induction of spines and spine synapses on the dendrites of CA1 pyramidal neurons, as well as alterations in long-term synaptic plasticity (LTP) and hippocampally dependent cognitive behaviors. How these effects occur remains largely unknown. Emerging evidence, however, suggests that one of the key elements in the response mechanism may be modulation of brain-derived neurotrophic factor (BDNF) in the mossy fiber (MF) system. In male rats, orchidectomy increases synaptic transmission and excitability in the MF pathway. Testosterone reverses these effects, suggesting that testosterone exerts tonic suppression on MF BDNF levels. These findings suggest that changes in hippocampal function resulting from declining androgen levels may reflect the outcome of responses mediated through normally balanced, but opposing, mechanisms: loss of androgen effects on the hippocampal circuitry may be compensated, at least in part, by an increase in BDNF-dependent MF plasticity.
Url:
DOI: 10.1177/1073858414558065
PubMed: 25416742
PubMed Central: 5002217
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PMC:5002217Le document en format XML
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<author><name sortKey="Atwi, Sarah" sort="Atwi, Sarah" uniqKey="Atwi S" first="Sarah" last="Atwi">Sarah Atwi</name>
<affiliation><nlm:aff id="A1">Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada</nlm:aff>
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<author><name sortKey="Mcmahon, Dallan" sort="Mcmahon, Dallan" uniqKey="Mcmahon D" first="Dallan" last="Mcmahon">Dallan Mcmahon</name>
<affiliation><nlm:aff id="A1">Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada</nlm:aff>
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<author><name sortKey="Scharfman, Helen" sort="Scharfman, Helen" uniqKey="Scharfman H" first="Helen" last="Scharfman">Helen Scharfman</name>
<affiliation><nlm:aff id="A2">The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA</nlm:aff>
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<affiliation><nlm:aff id="A3">Department of Child & Adolescent Psychiatry, Physiology & Neuroscience, and Psychiatry, New York University Langone Medical Center, New York, NY, USA</nlm:aff>
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<author><name sortKey="Maclusky, Neil J" sort="Maclusky, Neil J" uniqKey="Maclusky N" first="Neil J." last="Maclusky">Neil J. Maclusky</name>
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<author><name sortKey="Scharfman, Helen" sort="Scharfman, Helen" uniqKey="Scharfman H" first="Helen" last="Scharfman">Helen Scharfman</name>
<affiliation><nlm:aff id="A2">The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA</nlm:aff>
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<affiliation><nlm:aff id="A3">Department of Child & Adolescent Psychiatry, Physiology & Neuroscience, and Psychiatry, New York University Langone Medical Center, New York, NY, USA</nlm:aff>
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<author><name sortKey="Maclusky, Neil J" sort="Maclusky, Neil J" uniqKey="Maclusky N" first="Neil J." last="Maclusky">Neil J. Maclusky</name>
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<front><div type="abstract" xml:lang="en"><p id="P1">Androgens have profound effects on hippocampal structure and function, including induction of spines and spine synapses on the dendrites of CA1 pyramidal neurons, as well as alterations in long-term synaptic plasticity (LTP) and hippocampally dependent cognitive behaviors. How these effects occur remains largely unknown. Emerging evidence, however, suggests that one of the key elements in the response mechanism may be modulation of brain-derived neurotrophic factor (BDNF) in the mossy fiber (MF) system. In male rats, orchidectomy increases synaptic transmission and excitability in the MF pathway. Testosterone reverses these effects, suggesting that testosterone exerts tonic suppression on MF BDNF levels. These findings suggest that changes in hippocampal function resulting from declining androgen levels may reflect the outcome of responses mediated through normally balanced, but opposing, mechanisms: loss of androgen effects on the hippocampal circuitry may be compensated, at least in part, by an increase in BDNF-dependent MF plasticity.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9504819</journal-id>
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<contrib-group><contrib contrib-type="author"><name><surname>Atwi</surname>
<given-names>Sarah</given-names>
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<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>McMahon</surname>
<given-names>Dallan</given-names>
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<contrib contrib-type="author"><name><surname>Scharfman</surname>
<given-names>Helen</given-names>
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<xref ref-type="aff" rid="A2">2</xref>
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<given-names>Neil J.</given-names>
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<aff id="A1"><label>1</label>
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada</aff>
<aff id="A2"><label>2</label>
The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA</aff>
<aff id="A3"><label>3</label>
Department of Child & Adolescent Psychiatry, Physiology & Neuroscience, and Psychiatry, New York University Langone Medical Center, New York, NY, USA</aff>
<author-notes><corresp id="CR1"><bold>Corresponding Author:</bold>
Neil J. MacLusky, Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, 50 Stone Rd, Guelph, Ontario, Canada N1G 2W1. <email>nmaclusk@uoguelph.ca</email>
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<pub-date pub-type="nihms-submitted"><day>15</day>
<month>8</month>
<year>2016</year>
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<pub-date pub-type="epub"><day>21</day>
<month>11</month>
<year>2014</year>
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<pub-date pub-type="ppub"><month>2</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>27</day>
<month>8</month>
<year>2016</year>
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<volume>22</volume>
<issue>1</issue>
<fpage>46</fpage>
<lpage>60</lpage>
<pmc-comment>elocation-id from pubmed: 10.1177/1073858414558065</pmc-comment>
<permissions><license license-type="permissions-link"><license-p>Reprints and permissions: <ext-link ext-link-type="uri" xlink:href="http://sagepub.com/journalsPermissions.nav">sagepub.com/journalsPermissions.nav</ext-link>
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<abstract><p id="P1">Androgens have profound effects on hippocampal structure and function, including induction of spines and spine synapses on the dendrites of CA1 pyramidal neurons, as well as alterations in long-term synaptic plasticity (LTP) and hippocampally dependent cognitive behaviors. How these effects occur remains largely unknown. Emerging evidence, however, suggests that one of the key elements in the response mechanism may be modulation of brain-derived neurotrophic factor (BDNF) in the mossy fiber (MF) system. In male rats, orchidectomy increases synaptic transmission and excitability in the MF pathway. Testosterone reverses these effects, suggesting that testosterone exerts tonic suppression on MF BDNF levels. These findings suggest that changes in hippocampal function resulting from declining androgen levels may reflect the outcome of responses mediated through normally balanced, but opposing, mechanisms: loss of androgen effects on the hippocampal circuitry may be compensated, at least in part, by an increase in BDNF-dependent MF plasticity.</p>
</abstract>
<kwd-group><kwd>testosterone</kwd>
<kwd>hippocampus</kwd>
<kwd>BDNF</kwd>
<kwd>mossy fibers</kwd>
<kwd>CA3</kwd>
</kwd-group>
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