ParkinsonCanadaV1, Ncbi, Curation, bibRecord, 001955

Head injury, alpha-synuclein genetic variability and Parkinson’s disease

Identifieur interne : 001955 ( Ncbi/Curation ); précédent : 001954; suivant : 001956

Head injury, alpha-synuclein genetic variability and Parkinson’s disease

Auteurs : Pei-Chen Lee [Taïwan] ; Yvette Bordelon [États-Unis] ; Jeff Bronstein [États-Unis] ; Janet S. Sinsheimer [États-Unis] ; Matthew Farrer [Canada] ; Beate Ritz [États-Unis]

Source :

European journal of neurology : the official journal of the European Federation of Neurological Societies [ 1351-5101 ] ; 2014.

RBID : PMC:4390403

Abstract

Background

Head injury has been linked to Parkinson’s disease (PD) in some but not all studies. Differences in the genetic and environmental susceptibility to PD between populations might be one explanation. We investigate the joint effects of head injuries and SNCA genetic variants.

Methods

From 2001 to 2012, we enrolled 561 incident idiopathic PD cases and 721 population controls from central California. Subjects reported on head injuries throughout life-time and were assessed for genetic variability in the SNCA 5′ region (D4S3481; Rep1) and 3′ UTR (rs356165). In unconditional logistic regression models adjusted for confounders, we tested for interactions between head injuries and genetic risk variants.

Results

PD risk in individuals with head injury who are carriers of at least one 263bp allele in D4S3481 or rs356165 variants was 3–4.5 fold higher compared with non-carriers without head injuries. However, tests for interaction between head injury and SNCA D4S3481or rs356165 were not statistically significant.

Conclusions

Our study finds some evidence that head injury and D4S3481 or rs356165 variants jointly increase the risk of PD but little evidence of interaction.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390403

DOI: 10.1111/ene.12585
PubMed: 25370538
PubMed Central: 4390403

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PMC:4390403

Le document en format XML

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<author><name sortKey="Lee, Pei Chen" sort="Lee, Pei Chen" uniqKey="Lee P" first="Pei-Chen" last="Lee">Pei-Chen Lee</name>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Head injury has been linked to Parkinson’s disease (PD) in some but not all studies. Differences in the genetic and environmental susceptibility to PD between populations might be one explanation. We investigate the joint effects of head injuries and <italic>SNCA</italic>
 genetic variants.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">From 2001 to 2012, we enrolled 561 incident idiopathic PD cases and 721 population controls from central California. Subjects reported on head injuries throughout life-time and were assessed for genetic variability in the <italic>SNCA</italic>
 5′ region (D4S3481; Rep1) and 3′ UTR (rs356165). In unconditional logistic regression models adjusted for confounders, we tested for interactions between head injuries and genetic risk variants.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">PD risk in individuals with head injury who are carriers of at least one 263bp allele in D4S3481 or rs356165 variants was 3–4.5 fold higher compared with non-carriers without head injuries. However, tests for interaction between head injury and <italic>SNCA</italic>
 D4S3481or rs356165 were not statistically significant.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Our study finds some evidence that head injury and D4S3481 or rs356165 variants jointly increase the risk of PD but little evidence of interaction.</p>
</sec>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Head injury, alpha-synuclein genetic variability and Parkinson’s disease

Head injury, alpha-synuclein genetic variability and Parkinson’s disease

Source :

Abstract

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