Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.
Identifieur interne : 001D87 ( Ncbi/Checkpoint ); précédent : 001D86; suivant : 001D88Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.
Auteurs : Giuseppe Nicoletti [Italie] ; Vincenzo De Luca [Canada] ; Patrizia Tarantino [Italie] ; Monica Gagliardi [Italie] ; Grazia Iannello [Italie] ; Fabiana Novellino [Italie] ; Maurizio Morelli [Italie] ; Grazia Annesi [Italie] ; Aldo Quattrone [Italie]Source :
- Psychiatry research [ 1872-7123 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Alleles, Cognition Disorders (etiology), Cognition Disorders (genetics), Dementia (etiology), Dementia (genetics), Female, G-Protein-Coupled Receptor Kinase 5 (genetics), Genetic Association Studies, Genetic Predisposition to Disease, Haplotypes, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (genetics), Polymorphism, Single Nucleotide, Risk Factors.
- MESH :
- chemical , genetics : G-Protein-Coupled Receptor Kinase 5.
- complications : Parkinson Disease.
- etiology : Cognition Disorders, Dementia.
- genetics : Cognition Disorders, Dementia, Parkinson Disease.
- Aged, Alleles, Female, Genetic Association Studies, Genetic Predisposition to Disease, Haplotypes, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors.
Abstract
The objective of our study was to investigate the association of two single nucleotide polymorphisms (SNPs) with genetic risk of dementia. In 212 patients with Parkinson's disease (PD), we investigated two polymorphisms within the G-protein coupled receptor kinase 5 (GRK5) gene (rs2420616, rs4752293) to determine a possible risk factor for dementia. We identified two alleles most significantly present in PD patients with dementia: G and T alleles. We also identified risk haplotypes: GC, and AT. We demonstrated that the SNPs and the related haplotypes could play a central role in predisposing PD patients to cognitive impairment.
DOI: 10.1016/j.psychres.2015.11.026
PubMed: 26614013
Affiliations:
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<term>Dementia (genetics)</term>
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<front><div type="abstract" xml:lang="en">The objective of our study was to investigate the association of two single nucleotide polymorphisms (SNPs) with genetic risk of dementia. In 212 patients with Parkinson's disease (PD), we investigated two polymorphisms within the G-protein coupled receptor kinase 5 (GRK5) gene (rs2420616, rs4752293) to determine a possible risk factor for dementia. We identified two alleles most significantly present in PD patients with dementia: G and T alleles. We also identified risk haplotypes: GC, and AT. We demonstrated that the SNPs and the related haplotypes could play a central role in predisposing PD patients to cognitive impairment.</div>
</front>
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<tree><country name="Italie"><noRegion><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name>
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<name sortKey="Iannello, Grazia" sort="Iannello, Grazia" uniqKey="Iannello G" first="Grazia" last="Iannello">Grazia Iannello</name>
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<name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name>
<name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<name sortKey="Tarantino, Patrizia" sort="Tarantino, Patrizia" uniqKey="Tarantino P" first="Patrizia" last="Tarantino">Patrizia Tarantino</name>
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<country name="Canada"><region name="Ontario"><name sortKey="De Luca, Vincenzo" sort="De Luca, Vincenzo" uniqKey="De Luca V" first="Vincenzo" last="De Luca">Vincenzo De Luca</name>
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