ParkinsonCanadaV1, Ncbi, Curation, bibRecord, 001D87

Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.

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Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.

Auteurs : Giuseppe Nicoletti [Italie] ; Vincenzo De Luca [Canada] ; Patrizia Tarantino [Italie] ; Monica Gagliardi [Italie] ; Grazia Iannello [Italie] ; Fabiana Novellino [Italie] ; Maurizio Morelli [Italie] ; Grazia Annesi [Italie] ; Aldo Quattrone [Italie]

Source :

Psychiatry research [ 1872-7123 ] ; 2015.

RBID : pubmed:26614013

English descriptors

KwdEn :
- Aged, Alleles, Cognition Disorders (etiology), Cognition Disorders (genetics), Dementia (etiology), Dementia (genetics), Female, G-Protein-Coupled Receptor Kinase 5 (genetics), Genetic Association Studies, Genetic Predisposition to Disease, Haplotypes, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (genetics), Polymorphism, Single Nucleotide, Risk Factors.
MESH :
- chemical , genetics : G-Protein-Coupled Receptor Kinase 5.
- complications : Parkinson Disease.
- etiology : Cognition Disorders, Dementia.
- genetics : Cognition Disorders, Dementia, Parkinson Disease.
- Aged, Alleles, Female, Genetic Association Studies, Genetic Predisposition to Disease, Haplotypes, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors.

Abstract

The objective of our study was to investigate the association of two single nucleotide polymorphisms (SNPs) with genetic risk of dementia. In 212 patients with Parkinson's disease (PD), we investigated two polymorphisms within the G-protein coupled receptor kinase 5 (GRK5) gene (rs2420616, rs4752293) to determine a possible risk factor for dementia. We identified two alleles most significantly present in PD patients with dementia: G and T alleles. We also identified risk haplotypes: GC, and AT. We demonstrated that the SNPs and the related haplotypes could play a central role in predisposing PD patients to cognitive impairment.

DOI: 10.1016/j.psychres.2015.11.026
PubMed: 26614013

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<term>Dementia (etiology)</term>
<term>Dementia (genetics)</term>
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<front><div type="abstract" xml:lang="en">The objective of our study was to investigate the association of two single nucleotide polymorphisms (SNPs) with genetic risk of dementia. In 212 patients with Parkinson's disease (PD), we investigated two polymorphisms within the G-protein coupled receptor kinase 5 (GRK5) gene (rs2420616, rs4752293) to determine a possible risk factor for dementia. We identified two alleles most significantly present in PD patients with dementia: G and T alleles. We also identified risk haplotypes: GC, and AT. We demonstrated that the SNPs and the related haplotypes could play a central role in predisposing PD patients to cognitive impairment.</div>
</front>
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Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.

Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.

Source :

English descriptors

Abstract

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