Changes in hippocampal monoamine concentration following halothane anesthesia and concussion.
Identifieur interne : 004D20 ( Main/Merge ); précédent : 004D19; suivant : 004D21Changes in hippocampal monoamine concentration following halothane anesthesia and concussion.
Auteurs : G. Eschun [Canada] ; D. Parkinson ; J. VriendSource :
- Surgical neurology [ 0090-3019 ] ; 1992.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Biogenic Monoamines, Levodopa, Norepinephrine.
- metabolism : Brain Concussion, Hippocampus.
- physiology : Memory.
- Anesthesia, Inhalation, Animals, Halothane, Male, Random Allocation, Rats, Rats, Inbred Strains.
Abstract
The concentration of norepinephrine in the hippocampus of rats anesthetized with halothane (Wyeth-Ayerst, Philadelphia, Pa) is found to be markedly increased, presumably due to the stress of handling and administering the anesthetic. This increased norepinephrine concentration persists for about 50 minutes but is obliterated when the anesthetized rat is concussed. This 50-minute period corresponds to the time it takes for a rat (or human), comatose for 1-2 seconds following concussion, to regain normal memory. No changes in 3,4-dihydroxybenzene-acetic acid (DOPAC), 3-(3,4-dihydroxyphenyl) alanine (L-DOPA), and 3,4-dihydroxybenzylamine (DHBA) were noted. 5-Hydroxy indole acetic acid (HIAA) showed a depression at 5 minutes and again at 30 minutes, changes that were consistent but not considered statistically significant.
PubMed: 1546372
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pubmed:1546372Le document en format XML
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Eschun</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Medicine, University of Manitoba, Winnipeg, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Medicine, University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Parkinson, D" sort="Parkinson, D" uniqKey="Parkinson D" first="D" last="Parkinson">D. Parkinson</name></author><author><name sortKey="Vriend, J" sort="Vriend, J" uniqKey="Vriend J" first="J" last="Vriend">J. Vriend</name></author></analytic><series><title level="j">Surgical neurology</title><idno type="ISSN">0090-3019</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anesthesia, Inhalation</term><term>Animals</term><term>Biogenic Monoamines (metabolism)</term><term>Brain Concussion (metabolism)</term><term>Halothane</term><term>Hippocampus (metabolism)</term><term>Levodopa (metabolism)</term><term>Male</term><term>Memory (physiology)</term><term>Norepinephrine (metabolism)</term><term>Random Allocation</term><term>Rats</term><term>Rats, Inbred Strains</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biogenic Monoamines</term><term>Levodopa</term><term>Norepinephrine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain Concussion</term><term>Hippocampus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Anesthesia, Inhalation</term><term>Animals</term><term>Halothane</term><term>Male</term><term>Random Allocation</term><term>Rats</term><term>Rats, Inbred Strains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The concentration of norepinephrine in the hippocampus of rats anesthetized with halothane (Wyeth-Ayerst, Philadelphia, Pa) is found to be markedly increased, presumably due to the stress of handling and administering the anesthetic. This increased norepinephrine concentration persists for about 50 minutes but is obliterated when the anesthetized rat is concussed. This 50-minute period corresponds to the time it takes for a rat (or human), comatose for 1-2 seconds following concussion, to regain normal memory. No changes in 3,4-dihydroxybenzene-acetic acid (DOPAC), 3-(3,4-dihydroxyphenyl) alanine (L-DOPA), and 3,4-dihydroxybenzylamine (DHBA) were noted. 5-Hydroxy indole acetic acid (HIAA) showed a depression at 5 minutes and again at 30 minutes, changes that were consistent but not considered statistically significant.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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