Changes in hippocampal monoamine concentration following halothane anesthesia and concussion.
Identifieur interne : 001A83 ( PubMed/Corpus ); précédent : 001A82; suivant : 001A84Changes in hippocampal monoamine concentration following halothane anesthesia and concussion.
Auteurs : G. Eschun ; D. Parkinson ; J. VriendSource :
- Surgical neurology [ 0090-3019 ] ; 1992.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Biogenic Monoamines, Levodopa, Norepinephrine.
- metabolism : Brain Concussion, Hippocampus.
- physiology : Memory.
- Anesthesia, Inhalation, Animals, Halothane, Male, Random Allocation, Rats, Rats, Inbred Strains.
Abstract
The concentration of norepinephrine in the hippocampus of rats anesthetized with halothane (Wyeth-Ayerst, Philadelphia, Pa) is found to be markedly increased, presumably due to the stress of handling and administering the anesthetic. This increased norepinephrine concentration persists for about 50 minutes but is obliterated when the anesthetized rat is concussed. This 50-minute period corresponds to the time it takes for a rat (or human), comatose for 1-2 seconds following concussion, to regain normal memory. No changes in 3,4-dihydroxybenzene-acetic acid (DOPAC), 3-(3,4-dihydroxyphenyl) alanine (L-DOPA), and 3,4-dihydroxybenzylamine (DHBA) were noted. 5-Hydroxy indole acetic acid (HIAA) showed a depression at 5 minutes and again at 30 minutes, changes that were consistent but not considered statistically significant.
PubMed: 1546372
Links to Exploration step
pubmed:1546372Le document en format XML
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Vriend</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1546372</idno><idno type="pmid">1546372</idno><idno type="wicri:Area/PubMed/Corpus">001A83</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Changes in hippocampal monoamine concentration following halothane anesthesia and concussion.</title><author><name sortKey="Eschun, G" sort="Eschun, G" uniqKey="Eschun G" first="G" last="Eschun">G. Eschun</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Manitoba, Winnipeg, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Parkinson, D" sort="Parkinson, D" uniqKey="Parkinson D" first="D" last="Parkinson">D. Parkinson</name></author><author><name sortKey="Vriend, J" sort="Vriend, J" uniqKey="Vriend J" first="J" last="Vriend">J. Vriend</name></author></analytic><series><title level="j">Surgical neurology</title><idno type="ISSN">0090-3019</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anesthesia, Inhalation</term><term>Animals</term><term>Biogenic Monoamines (metabolism)</term><term>Brain Concussion (metabolism)</term><term>Halothane</term><term>Hippocampus (metabolism)</term><term>Levodopa (metabolism)</term><term>Male</term><term>Memory (physiology)</term><term>Norepinephrine (metabolism)</term><term>Random Allocation</term><term>Rats</term><term>Rats, Inbred Strains</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biogenic Monoamines</term><term>Levodopa</term><term>Norepinephrine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain Concussion</term><term>Hippocampus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Anesthesia, Inhalation</term><term>Animals</term><term>Halothane</term><term>Male</term><term>Random Allocation</term><term>Rats</term><term>Rats, Inbred Strains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The concentration of norepinephrine in the hippocampus of rats anesthetized with halothane (Wyeth-Ayerst, Philadelphia, Pa) is found to be markedly increased, presumably due to the stress of handling and administering the anesthetic. This increased norepinephrine concentration persists for about 50 minutes but is obliterated when the anesthetized rat is concussed. This 50-minute period corresponds to the time it takes for a rat (or human), comatose for 1-2 seconds following concussion, to regain normal memory. No changes in 3,4-dihydroxybenzene-acetic acid (DOPAC), 3-(3,4-dihydroxyphenyl) alanine (L-DOPA), and 3,4-dihydroxybenzylamine (DHBA) were noted. 5-Hydroxy indole acetic acid (HIAA) showed a depression at 5 minutes and again at 30 minutes, changes that were consistent but not considered statistically significant.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1546372</PMID><DateCreated><Year>1992</Year><Month>04</Month><Day>16</Day></DateCreated><DateCompleted><Year>1992</Year><Month>04</Month><Day>16</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0090-3019</ISSN><JournalIssue CitedMedium="Print"><Volume>37</Volume><Issue>2</Issue><PubDate><Year>1992</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Surgical neurology</Title><ISOAbbreviation>Surg Neurol</ISOAbbreviation></Journal><ArticleTitle>Changes in hippocampal monoamine concentration following halothane anesthesia and concussion.</ArticleTitle><Pagination><MedlinePgn>101-5</MedlinePgn></Pagination><Abstract><AbstractText>The concentration of norepinephrine in the hippocampus of rats anesthetized with halothane (Wyeth-Ayerst, Philadelphia, Pa) is found to be markedly increased, presumably due to the stress of handling and administering the anesthetic. This increased norepinephrine concentration persists for about 50 minutes but is obliterated when the anesthetized rat is concussed. This 50-minute period corresponds to the time it takes for a rat (or human), comatose for 1-2 seconds following concussion, to regain normal memory. No changes in 3,4-dihydroxybenzene-acetic acid (DOPAC), 3-(3,4-dihydroxyphenyl) alanine (L-DOPA), and 3,4-dihydroxybenzylamine (DHBA) were noted. 5-Hydroxy indole acetic acid (HIAA) showed a depression at 5 minutes and again at 30 minutes, changes that were consistent but not considered statistically significant.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Eschun</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Manitoba, Winnipeg, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parkinson</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Vriend</LastName><ForeName>J</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Surg Neurol</MedlineTA><NlmUniqueID>0367070</NlmUniqueID><ISSNLinking>0090-3019</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015306">Biogenic Monoamines</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical><Chemical><RegistryNumber>UQT9G45D1P</RegistryNumber><NameOfSubstance UI="D006221">Halothane</NameOfSubstance></Chemical><Chemical><RegistryNumber>X4W3ENH1CV</RegistryNumber><NameOfSubstance UI="D009638">Norepinephrine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000769" MajorTopicYN="N">Anesthesia, Inhalation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015306" MajorTopicYN="N">Biogenic Monoamines</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001924" MajorTopicYN="N">Brain Concussion</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006221" MajorTopicYN="N">Halothane</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006624" MajorTopicYN="N">Hippocampus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008568" MajorTopicYN="N">Memory</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009638" MajorTopicYN="N">Norepinephrine</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011919" MajorTopicYN="N">Rats, Inbred Strains</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1992</Year><Month>2</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1992</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1992</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1546372</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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