Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys.
Identifieur interne : 003C02 ( Main/Merge ); précédent : 003C01; suivant : 003C03Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys.
Auteurs : R. Grondin [Canada] ; P J Bédard ; A. Hadj Tahar ; L. Grégoire ; A. Mori ; H. KaseSource :
- Neurology [ 0028-3878 ] ; 1999.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (adverse effects), Animals, Brain (drug effects), Female, Levodopa (pharmacology), Levodopa (therapeutic use), Locomotion (drug effects), Macaca fascicularis, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (drug therapy), Purinergic P1 Receptor Antagonists, Purines (pharmacology), Purines (therapeutic use), Receptor, Adenosine A2A.
- MESH :
- chemical , adverse effects : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- chemically induced : Parkinson Disease, Secondary.
- drug effects : Brain, Locomotion.
- drug therapy : Parkinson Disease, Secondary.
- chemical , pharmacology : Levodopa, Purines.
- chemical , therapeutic use : Levodopa, Purines.
- Animals, Female, Macaca fascicularis, Purinergic P1 Receptor Antagonists, Receptor, Adenosine A2A.
Abstract
Chronic treatment with L-3,4-dihydroxyphenylalanine (L-dopa) is often associated with motor side effects in PD patients. The search for new therapeutic approaches has led to study the role of other neuromodulators including adenosine. Among the four adenosine receptors characterized so far, the A2A subtype is distinctively present on striatopallidal output neurons containing enkephalin and mainly bearing dopamine (DA) D2 receptors (indirect pathway). Studies in DA-denervated rats suggest that blockade of adenosine A2A receptors might be used in PD.
PubMed: 10331698
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pubmed:10331698Le document en format XML
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Hadj Tahar</name></author><author><name sortKey="Gregoire, L" sort="Gregoire, L" uniqKey="Gregoire L" first="L" last="Grégoire">L. Grégoire</name></author><author><name sortKey="Mori, A" sort="Mori, A" uniqKey="Mori A" first="A" last="Mori">A. Mori</name></author><author><name sortKey="Kase, H" sort="Kase, H" uniqKey="Kase H" first="H" last="Kase">H. 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Grondin</name><affiliation wicri:level="1"><nlm:affiliation>Neuroscience Research Unit, Laval University Research Center, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Neuroscience Research Unit, Laval University Research Center, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P J" last="Bédard">P J Bédard</name></author><author><name sortKey="Hadj Tahar, A" sort="Hadj Tahar, A" uniqKey="Hadj Tahar A" first="A" last="Hadj Tahar">A. Hadj Tahar</name></author><author><name sortKey="Gregoire, L" sort="Gregoire, L" uniqKey="Gregoire L" first="L" last="Grégoire">L. Grégoire</name></author><author><name sortKey="Mori, A" sort="Mori, A" uniqKey="Mori A" first="A" last="Mori">A. Mori</name></author><author><name sortKey="Kase, H" sort="Kase, H" uniqKey="Kase H" first="H" last="Kase">H. Kase</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (adverse effects)</term><term>Animals</term><term>Brain (drug effects)</term><term>Female</term><term>Levodopa (pharmacology)</term><term>Levodopa (therapeutic use)</term><term>Locomotion (drug effects)</term><term>Macaca fascicularis</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Parkinson Disease, Secondary (drug therapy)</term><term>Purinergic P1 Receptor Antagonists</term><term>Purines (pharmacology)</term><term>Purines (therapeutic use)</term><term>Receptor, Adenosine A2A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term><term>Locomotion</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Levodopa</term><term>Purines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term><term>Purines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Macaca fascicularis</term><term>Purinergic P1 Receptor Antagonists</term><term>Receptor, Adenosine A2A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chronic treatment with L-3,4-dihydroxyphenylalanine (L-dopa) is often associated with motor side effects in PD patients. The search for new therapeutic approaches has led to study the role of other neuromodulators including adenosine. Among the four adenosine receptors characterized so far, the A2A subtype is distinctively present on striatopallidal output neurons containing enkephalin and mainly bearing dopamine (DA) D2 receptors (indirect pathway). Studies in DA-denervated rats suggest that blockade of adenosine A2A receptors might be used in PD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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