Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson's disease.
Identifieur interne : 001712 ( PubMed/Checkpoint ); précédent : 001711; suivant : 001713Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson's disease.
Auteurs : R. Kumar [Canada] ; A M Lozano ; Y J Kim ; W D Hutchison ; E. Sime ; E. Halket ; A E LangSource :
- Neurology [ 0028-3878 ] ; 1998.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Electric Stimulation Therapy.
- physiology : Thalamus.
- therapy : Parkinson Disease.
- Aged, Double-Blind Method, Evaluation Studies as Topic, Female, Humans, Male, Middle Aged, Treatment Outcome.
Abstract
To examine objectively the clinical effects of subthalamic nucleus (STN) deep brain stimulation (DBS) in advanced PD.
PubMed: 9748038
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson's disease.</title><author><name sortKey="Kumar, R" sort="Kumar, R" uniqKey="Kumar R" first="R" last="Kumar">R. Kumar</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neurology, Faculty of Medicine, University of Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, Faculty of Medicine, University of Toronto</wicri:regionArea><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A M" last="Lozano">A M Lozano</name></author><author><name sortKey="Kim, Y J" sort="Kim, Y J" uniqKey="Kim Y" first="Y J" last="Kim">Y J Kim</name></author><author><name sortKey="Hutchison, W D" sort="Hutchison, W D" uniqKey="Hutchison W" first="W D" last="Hutchison">W D Hutchison</name></author><author><name sortKey="Sime, E" sort="Sime, E" uniqKey="Sime E" first="E" last="Sime">E. Sime</name></author><author><name sortKey="Halket, E" sort="Halket, E" uniqKey="Halket E" first="E" last="Halket">E. Halket</name></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9748038</idno><idno type="pmid">9748038</idno><idno type="wicri:Area/PubMed/Corpus">001756</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001756</idno><idno type="wicri:Area/PubMed/Curation">001756</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001756</idno><idno type="wicri:Area/PubMed/Checkpoint">001756</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001756</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson's disease.</title><author><name sortKey="Kumar, R" sort="Kumar, R" uniqKey="Kumar R" first="R" last="Kumar">R. Kumar</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neurology, Faculty of Medicine, University of Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, Faculty of Medicine, University of Toronto</wicri:regionArea><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A M" last="Lozano">A M Lozano</name></author><author><name sortKey="Kim, Y J" sort="Kim, Y J" uniqKey="Kim Y" first="Y J" last="Kim">Y J Kim</name></author><author><name sortKey="Hutchison, W D" sort="Hutchison, W D" uniqKey="Hutchison W" first="W D" last="Hutchison">W D Hutchison</name></author><author><name sortKey="Sime, E" sort="Sime, E" uniqKey="Sime E" first="E" last="Sime">E. Sime</name></author><author><name sortKey="Halket, E" sort="Halket, E" uniqKey="Halket E" first="E" last="Halket">E. Halket</name></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Double-Blind Method</term><term>Electric Stimulation Therapy (adverse effects)</term><term>Evaluation Studies as Topic</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (therapy)</term><term>Thalamus (physiology)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Electric Stimulation Therapy</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Double-Blind Method</term><term>Evaluation Studies as Topic</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To examine objectively the clinical effects of subthalamic nucleus (STN) deep brain stimulation (DBS) in advanced PD.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9748038</PMID><DateCreated><Year>1998</Year><Month>10</Month><Day>20</Day></DateCreated><DateCompleted><Year>1998</Year><Month>10</Month><Day>20</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0028-3878</ISSN><JournalIssue CitedMedium="Print"><Volume>51</Volume><Issue>3</Issue><PubDate><Year>1998</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>850-5</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To examine objectively the clinical effects of subthalamic nucleus (STN) deep brain stimulation (DBS) in advanced PD.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Our initial seven consecutive patients with medication-refractory motor fluctuations and levodopa-induced dyskinesias undergoing chronic STN DBS underwent a standardized preoperative evaluation followed by a 2-day double-blind evaluation of efficacy 6 to 12 months after electrode implantation. Diaries documenting motor fluctuations and dyskinesias were also completed preoperatively and postoperatively.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In the medication-off state, turning the stimulators on resulted in improvement in mean total Unified Parkinson's Disease Rating Scale (UPDRS) motor score by 58% including the following improvements in composite scores: akinesia 57%, rigidity 52%, tremor 82%, and gait and postural stability 49%. Additionally, the medication-off state improved 17% without stimulation, possibly as a result of electrode insertion alone or carry-over of chronic stimulation. In the medication-on, stimulation-on state, all major features of parkinsonism improved and total UPDRS motor score improved 41% compared with before surgery. Activities of daily living were improved while off medication 30%, and levodopa-induced dyskinesias were reduced 83% while total drug dosage was decreased 40%. With chronic stimulation, patients reported that the percentage of time spent in the "on" state (without dyskinesias) increased from 26% to 52% and "off" time decreased from 30% to 6%. Operative complications including cognitive worsening were not uncommon.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">STN DBS is a promising new surgical option for the treatment of advanced PD. The marked clinical benefits obtained in these severely disabled patients outweighed the adverse effects.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Neurology, Faculty of Medicine, University of Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lozano</LastName><ForeName>A M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Y J</ForeName><Initials>YJ</Initials></Author><Author ValidYN="Y"><LastName>Hutchison</LastName><ForeName>W D</ForeName><Initials>WD</Initials></Author><Author ValidYN="Y"><LastName>Sime</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Halket</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Lang</LastName><ForeName>A E</ForeName><Initials>AE</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004599" MajorTopicYN="N">Electric Stimulation Therapy</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005069" MajorTopicYN="N">Evaluation Studies as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013788" MajorTopicYN="N">Thalamus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>9</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>9</Month><Day>25</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>9</Month><Day>25</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9748038</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Halket, E" sort="Halket, E" uniqKey="Halket E" first="E" last="Halket">E. Halket</name><name sortKey="Hutchison, W D" sort="Hutchison, W D" uniqKey="Hutchison W" first="W D" last="Hutchison">W D Hutchison</name><name sortKey="Kim, Y J" sort="Kim, Y J" uniqKey="Kim Y" first="Y J" last="Kim">Y J Kim</name><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A M" last="Lozano">A M Lozano</name><name sortKey="Sime, E" sort="Sime, E" uniqKey="Sime E" first="E" last="Sime">E. Sime</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Kumar, R" sort="Kumar, R" uniqKey="Kumar R" first="R" last="Kumar">R. Kumar</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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