ParkinsonCanadaV1, Main, Merge, bibRecord, 003303

Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study

Identifieur interne : 003303 ( Main/Merge ); précédent : 003302; suivant : 003304

Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study

Auteurs : Alan L. Whone [Royaume-Uni] ; Ray L. Watts [États-Unis] ; A. Jon Stoessl [Canada] ; Margaret Davis [États-Unis] ; Sven Reske [Allemagne] ; Claude Nahmias [Canada] ; Anthony E. Lang [Canada] ; Olivier Rascol [France] ; Maria J. Ribeiro [France] ; Philippe Remy [France] ; Werner Poewe [Autriche] ; Robert A. Hauser [États-Unis] ; David J. Brooks [Royaume-Uni]

Source :

Annals of neurology [ 0364-5134 ] ; 2003.

RBID : Pascal:03-0498653

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Ropinirole, Tomoscintigraphie, Dopa, Dopamine, Putamen, Cartographie, Etude comparative, Lévodopa, Positon, Stimulant dopaminergique, Etude double insu, Homme, Pronostic, Agoniste, Récepteur dopaminergique D2, Aminoacide, Catécholamine, Captation.
Wicri :
- topic : Cartographie, Homme.

English descriptors

KwdEn :
- Agonist, Aminoacid, Cartography, Catecholamine, Comparative study, D2 Dopamine receptor, Dopa, Dopamine, Dopamine agonist, Double blind study, Emission tomography, Human, Levodopa, Parkinson disease, Positron, Prognosis, Putamen, Ropinirole, Uptake.

Abstract

Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot clinical study using ¹⁸F-dopa positron emission tomography (PET) suggested a slower loss of striatal dopamine storage with ropinirole compared with levodopa. This prospective, 2-year, randomized, double-blind, multinational study compared the rates of loss of dopamine-terminal function in de novo patients with clinical and ¹⁸F-dopa PET evidence of early PD, randomized 1 to 1 to receive either ropinirole or levodopa. The primary outcome measure was reduction in putamen ¹⁸F-dopa uptake (Ki) between baseline and 2-year PET. Of 186, 162 randomized patients were eligible for analysis. A blinded, central, region-of-interest analysis showed a significantly lower reduction (p = 0.022) in putamen Ki over 2 years with ropinirole (-13.4%; n = 68) compared with levodopa (-20.3%; n = 59; 95% confidence interval [CI], 0.65-13.06). Statistical parametric mapping localized lesser reductions in ¹⁸F-dopa uptake in the putamen and substantia nigra with ropinirole. The greatest Ki decrease in each group was in the putamen (ropinirole, -14.1%; levodopa, -22.9%; 95% CI, 4.24-13.3), but the decrease was significantly lower with ropinirole compared with levodopa (p < 0.001). Ropinirole is associated with slower progression of PD than levodopa as assessed by ¹⁸F-dopa PET.

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study</title>
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<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
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<author><name sortKey="Ribeiro, Maria J" sort="Ribeiro, Maria J" uniqKey="Ribeiro M" first="Maria J." last="Ribeiro">Maria J. Ribeiro</name>
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<author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name>
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<country>États-Unis</country>
<wicri:noRegion>University of South Florida and Tampa General Healthcare</wicri:noRegion>
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<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
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<series><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
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<imprint><date when="2003">2003</date>
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<seriesStmt><title level="j" type="main">Annals of neurology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agonist</term>
<term>Aminoacid</term>
<term>Cartography</term>
<term>Catecholamine</term>
<term>Comparative study</term>
<term>D2 Dopamine receptor</term>
<term>Dopa</term>
<term>Dopamine</term>
<term>Dopamine agonist</term>
<term>Double blind study</term>
<term>Emission tomography</term>
<term>Human</term>
<term>Levodopa</term>
<term>Parkinson disease</term>
<term>Positron</term>
<term>Prognosis</term>
<term>Putamen</term>
<term>Ropinirole</term>
<term>Uptake</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Ropinirole</term>
<term>Tomoscintigraphie</term>
<term>Dopa</term>
<term>Dopamine</term>
<term>Putamen</term>
<term>Cartographie</term>
<term>Etude comparative</term>
<term>Lévodopa</term>
<term>Positon</term>
<term>Stimulant dopaminergique</term>
<term>Etude double insu</term>
<term>Homme</term>
<term>Pronostic</term>
<term>Agoniste</term>
<term>Récepteur dopaminergique D2</term>
<term>Aminoacide</term>
<term>Catécholamine</term>
<term>Captation</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cartographie</term>
<term>Homme</term>
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<front><div type="abstract" xml:lang="en">Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot clinical study using <sup>18</sup>
F-dopa positron emission tomography (PET) suggested a slower loss of striatal dopamine storage with ropinirole compared with levodopa. This prospective, 2-year, randomized, double-blind, multinational study compared the rates of loss of dopamine-terminal function in de novo patients with clinical and <sup>18</sup>
F-dopa PET evidence of early PD, randomized 1 to 1 to receive either ropinirole or levodopa. The primary outcome measure was reduction in putamen <sup>18</sup>
F-dopa uptake (Ki) between baseline and 2-year PET. Of 186, 162 randomized patients were eligible for analysis. A blinded, central, region-of-interest analysis showed a significantly lower reduction (p = 0.022) in putamen Ki over 2 years with ropinirole (-13.4%; n = 68) compared with levodopa (-20.3%; n = 59; 95% confidence interval [CI], 0.65-13.06). Statistical parametric mapping localized lesser reductions in <sup>18</sup>
F-dopa uptake in the putamen and substantia nigra with ropinirole. The greatest Ki decrease in each group was in the putamen (ropinirole, -14.1%; levodopa, -22.9%; 95% CI, 4.24-13.3), but the decrease was significantly lower with ropinirole compared with levodopa (p < 0.001). Ropinirole is associated with slower progression of PD than levodopa as assessed by <sup>18</sup>
F-dopa PET.</div>
</front>
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<li>Autriche</li>
<li>Canada</li>
<li>France</li>
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</country>
<region><li>Angleterre</li>
<li>Bade-Wurtemberg</li>
<li>District de Tübingen</li>
<li>Grand Londres</li>
<li>Midi-Pyrénées</li>
<li>Occitanie (région administrative)</li>
<li>Ontario</li>
<li>Tyrol (Land)</li>
</region>
<settlement><li>Hamilton (Ontario)</li>
<li>Innsbruck</li>
<li>Londres</li>
<li>Orsay</li>
<li>Toronto</li>
<li>Toulouse</li>
<li>Ulm</li>
</settlement>
<orgName><li>Université McMaster</li>
<li>Université d'Ulm</li>
<li>Université de Toronto</li>
<li>Université de médecine d'Innsbruck</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Whone, Alan L" sort="Whone, Alan L" uniqKey="Whone A" first="Alan L." last="Whone">Alan L. Whone</name>
</region>
<name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name>
</noRegion>
<name sortKey="Davis, Margaret" sort="Davis, Margaret" uniqKey="Davis M" first="Margaret" last="Davis">Margaret Davis</name>
<name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
</country>
<country name="Canada"><noRegion><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name>
</noRegion>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<name sortKey="Nahmias, Claude" sort="Nahmias, Claude" uniqKey="Nahmias C" first="Claude" last="Nahmias">Claude Nahmias</name>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Reske, Sven" sort="Reske, Sven" uniqKey="Reske S" first="Sven" last="Reske">Sven Reske</name>
</region>
</country>
<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
</region>
<name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name>
<name sortKey="Ribeiro, Maria J" sort="Ribeiro, Maria J" uniqKey="Ribeiro M" first="Maria J." last="Ribeiro">Maria J. Ribeiro</name>
</country>
<country name="Autriche"><region name="Tyrol (Land)"><name sortKey="Poewe, Werner H" sort="Poewe, Werner H" uniqKey="Poewe W" first="Werner H." last="Poewe">Werner Poewe</name>
</region>
</country>
</tree>
</affiliations>
</record>

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   |wiki=    Wicri/Canada
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   |clé=     Pascal:03-0498653
   |texte=   Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study
}}

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study

Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study

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