Crossroads in GDNF therapy for Parkinson's disease
Identifieur interne : 002C42 ( Main/Merge ); précédent : 002C41; suivant : 002C43Crossroads in GDNF therapy for Parkinson's disease
Auteurs : Todd B. Sherer [États-Unis] ; Brian K. Fiske [États-Unis] ; Clive N. Svendsen [États-Unis] ; Anthony E. Lang [Canada] ; J. William Langston [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The development of a neuroprotective or neuroregenerative therapy for Parkinson's disease (PD) would be a major therapeutic advance. Unfortunately, results from a recent controlled clinical study delivering the neurotrophic factor. glial-derived neurotrophic factor (GDNF), directly into brain did not demonstrate efficacy and safety of such a treatment. A critical review of available data suggests that there are questions that need to be answered before the future of GDNF as a therapy for PD can be determined.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000854
- to stream PascalFrancis, to step Curation: 000469
- to stream PascalFrancis, to step Checkpoint: 000744
Links to Exploration step
Pascal:06-0171936Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Crossroads in GDNF therapy for Parkinson's disease</title><author><name sortKey="Sherer, Todd B" sort="Sherer, Todd B" uniqKey="Sherer T" first="Todd B." last="Sherer">Todd B. Sherer</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Michael J. Fox Foundation for Parkinson's Research</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Fiske, Brian K" sort="Fiske, Brian K" uniqKey="Fiske B" first="Brian K." last="Fiske">Brian K. Fiske</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Michael J. Fox Foundation for Parkinson's Research</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Svendsen, Clive N" sort="Svendsen, Clive N" uniqKey="Svendsen C" first="Clive N." last="Svendsen">Clive N. Svendsen</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Waisman Center, University of Wisconsin</s1><s2>Madison, Wisconsin</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Movement Disorders Centre. Toronto Western Hospital</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Movement Disorders Centre. Toronto Western Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Langston, J William" sort="Langston, J William" uniqKey="Langston J" first="J. William" last="Langston">J. William Langston</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Parkinson's Institute</s1><s2>Sunnyvale, California</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0171936</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0171936 INIST</idno><idno type="RBID">Pascal:06-0171936</idno><idno type="wicri:Area/PascalFrancis/Corpus">000854</idno><idno type="wicri:Area/PascalFrancis/Curation">000469</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000744</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000744</idno><idno type="wicri:doubleKey">0885-3185:2006:Sherer T:crossroads:in:gdnf</idno><idno type="wicri:Area/Main/Merge">002C42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Crossroads in GDNF therapy for Parkinson's disease</title><author><name sortKey="Sherer, Todd B" sort="Sherer, Todd B" uniqKey="Sherer T" first="Todd B." last="Sherer">Todd B. Sherer</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Michael J. Fox Foundation for Parkinson's Research</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Fiske, Brian K" sort="Fiske, Brian K" uniqKey="Fiske B" first="Brian K." last="Fiske">Brian K. Fiske</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Michael J. Fox Foundation for Parkinson's Research</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Svendsen, Clive N" sort="Svendsen, Clive N" uniqKey="Svendsen C" first="Clive N." last="Svendsen">Clive N. Svendsen</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Waisman Center, University of Wisconsin</s1><s2>Madison, Wisconsin</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Movement Disorders Centre. Toronto Western Hospital</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Movement Disorders Centre. Toronto Western Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Langston, J William" sort="Langston, J William" uniqKey="Langston J" first="J. William" last="Langston">J. William Langston</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Parkinson's Institute</s1><s2>Sunnyvale, California</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical trial</term><term>Glial cell line derived neurotrophic factor</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Facteur GDNF</term><term>Traitement</term><term>Essai clinique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The development of a neuroprotective or neuroregenerative therapy for Parkinson's disease (PD) would be a major therapeutic advance. Unfortunately, results from a recent controlled clinical study delivering the neurotrophic factor. glial-derived neurotrophic factor (GDNF), directly into brain did not demonstrate efficacy and safety of such a treatment. A critical review of available data suggests that there are questions that need to be answered before the future of GDNF as a therapy for PD can be determined.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Californie</li><li>Wisconsin</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Sherer, Todd B" sort="Sherer, Todd B" uniqKey="Sherer T" first="Todd B." last="Sherer">Todd B. Sherer</name></region><name sortKey="Fiske, Brian K" sort="Fiske, Brian K" uniqKey="Fiske B" first="Brian K." last="Fiske">Brian K. Fiske</name><name sortKey="Langston, J William" sort="Langston, J William" uniqKey="Langston J" first="J. William" last="Langston">J. William Langston</name><name sortKey="Svendsen, Clive N" sort="Svendsen, Clive N" uniqKey="Svendsen C" first="Clive N." last="Svendsen">Clive N. Svendsen</name></country><country name="Canada"><noRegion><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002C42 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 002C42 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Merge
|type= RBID
|clé= Pascal:06-0171936
|texte= Crossroads in GDNF therapy for Parkinson's disease
}}
| This area was generated with Dilib version V0.6.29. |  |