ParkinsonCanadaV1, Main, Merge, bibRecord, 001396

Solvent exposures and parkinson disease risk in twins

Identifieur interne : 001396 ( Main/Merge ); précédent : 001395; suivant : 001397

Solvent exposures and parkinson disease risk in twins

Auteurs : Samuel M. Goldman [États-Unis] ; Patricia J. Quinlan [États-Unis] ; G. Webster Ross [États-Unis] ; Connie Marras [Canada] ; Cheryl Meng [États-Unis] ; Grace S. Bhudhikanok [États-Unis] ; Kathleen Comyns [États-Unis] ; Monica Korell [États-Unis] ; Anabel R. Chade [Argentine] ; Meike Kasten [Allemagne] ; Benjamin Priestley [États-Unis] ; Kelvin L. Chou [États-Unis] ; Hubert H. Fernandez [États-Unis] ; Franca Cambi [États-Unis] ; J. William Langston [États-Unis] ; Caroline M. Tanner [États-Unis]

Source :

Annals of Neurology [ 0364-5134 ] ; 2012-06.

RBID : ISTEX:B655BD278FE2134868D5B0775D536F121814E276

Abstract

Several case reports have linked solvent exposure to Parkinson disease (PD), but few studies have assessed associations with specific agents using an analytic epidemiologic design. We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design.

Url:

DOI: 10.1002/ana.22629

Links to Exploration step

ISTEX:B655BD278FE2134868D5B0775D536F121814E276

Le document en format XML

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<front><div type="abstract">Several case reports have linked solvent exposure to Parkinson disease (PD), but few studies have assessed associations with specific agents using an analytic epidemiologic design. We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design.</div>
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</placeName>
<wicri:cityArea>University of Michigan Health System, Department of Neurology, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic, Center for Neurology Restoration, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>University of Kentucky, Department of Neurology, Lexington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Langston, J William" sort="Langston, J William" uniqKey="Langston J" first="J. William" last="Langston">J. William Langston</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson's Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson's Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Annals of Neurology</title>
<title level="j" type="abbrev">Ann Neurol.</title>
<idno type="ISSN">0364-5134</idno>
<idno type="eISSN">1531-8249</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2012-06">2012-06</date>
<biblScope unit="volume">71</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="776">776</biblScope>
<biblScope unit="page" to="784">784</biblScope>
</imprint>
<idno type="ISSN">0364-5134</idno>
</series>
<idno type="istex">B655BD278FE2134868D5B0775D536F121814E276</idno>
<idno type="DOI">10.1002/ana.22629</idno>
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<front><div type="abstract">Several case reports have linked solvent exposure to Parkinson disease (PD), but few studies have assessed associations with specific agents using an analytic epidemiologic design. We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design.</div>
</front>
</TEI>
</ISTEX>
<PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Solvent Exposures and Parkinson’s Disease Risk in Twins</title>
<author><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M" last="Goldman">Samuel M. Goldman</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Quinlan, Patricia J" sort="Quinlan, Patricia J" uniqKey="Quinlan P" first="Patricia J" last="Quinlan">Patricia J. Quinlan</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
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<wicri:cityArea>Department of Medicine, Division of Occupational and Environmental Medicine, University of California, San Francisco</wicri:cityArea>
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</author>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name>
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<placeName><region type="state">Hawaï</region>
</placeName>
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</affiliation>
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<author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
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<author><name sortKey="Meng, Cheryl" sort="Meng, Cheryl" uniqKey="Meng C" first="Cheryl" last="Meng">Cheryl Meng</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
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</author>
<author><name sortKey="Bhudhikanok, Grace S" sort="Bhudhikanok, Grace S" uniqKey="Bhudhikanok G" first="Grace S" last="Bhudhikanok">Grace S. Bhudhikanok</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Comyns, Kathleen" sort="Comyns, Kathleen" uniqKey="Comyns K" first="Kathleen" last="Comyns">Kathleen Comyns</name>
<affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Korell, Monica" sort="Korell, Monica" uniqKey="Korell M" first="Monica" last="Korell">Monica Korell</name>
<affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chade, Anabel R" sort="Chade, Anabel R" uniqKey="Chade A" first="Anabel R" last="Chade">Anabel R. Chade</name>
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<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Favaloro University, Institute of Cognitive Neurology (INECO), and Institute of Neurosciences, Buenos Aires</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Kasten, Meike" sort="Kasten, Meike" uniqKey="Kasten M" first="Meike" last="Kasten">Meike Kasten</name>
<affiliation wicri:level="1"><nlm:aff id="A6">University of Lubeck, Department of Neurology, Lubeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Lubeck, Department of Neurology, Lubeck</wicri:regionArea>
<wicri:noRegion>Lubeck</wicri:noRegion>
<wicri:noRegion>Lubeck</wicri:noRegion>
<wicri:noRegion>Lubeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Priestley, Benjamin" sort="Priestley, Benjamin" uniqKey="Priestley B" first="Benjamin" last="Priestley">Benjamin Priestley</name>
<affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chou, Kelvin L" sort="Chou, Kelvin L" uniqKey="Chou K" first="Kelvin L" last="Chou">Kelvin L. Chou</name>
<affiliation wicri:level="2"><nlm:aff id="A7">University of Michigan Health System, Department of Neurology, Ann Arbor, MI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>University of Michigan Health System, Department of Neurology, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic, Center for Neurology Restoration, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic, Center for Neurology Restoration, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<affiliation wicri:level="2"><nlm:aff id="A9">University of Kentucky, Department of Neurology, Lexington, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>University of Kentucky, Department of Neurology, Lexington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Langston, J William" sort="Langston, J William" uniqKey="Langston J" first="J William" last="Langston">J William Langston</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Solvent Exposures and Parkinson’s Disease Risk in Twins</title>
<author><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M" last="Goldman">Samuel M. Goldman</name>
<affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Quinlan, Patricia J" sort="Quinlan, Patricia J" uniqKey="Quinlan P" first="Patricia J" last="Quinlan">Patricia J. Quinlan</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Medicine, Division of Occupational and Environmental Medicine, University of California, San Francisco, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Medicine, Division of Occupational and Environmental Medicine, University of California, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Veterans Affairs Pacific Islands Health Care System, Honolulu, HI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Veterans Affairs Pacific Islands Health Care System, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
<affiliation wicri:level="4"><nlm:aff id="A4">Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meng, Cheryl" sort="Meng, Cheryl" uniqKey="Meng C" first="Cheryl" last="Meng">Cheryl Meng</name>
<affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bhudhikanok, Grace S" sort="Bhudhikanok, Grace S" uniqKey="Bhudhikanok G" first="Grace S" last="Bhudhikanok">Grace S. Bhudhikanok</name>
<affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Comyns, Kathleen" sort="Comyns, Kathleen" uniqKey="Comyns K" first="Kathleen" last="Comyns">Kathleen Comyns</name>
<affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Korell, Monica" sort="Korell, Monica" uniqKey="Korell M" first="Monica" last="Korell">Monica Korell</name>
<affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chade, Anabel R" sort="Chade, Anabel R" uniqKey="Chade A" first="Anabel R" last="Chade">Anabel R. Chade</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Favaloro University, Institute of Cognitive Neurology (INECO), and Institute of Neurosciences, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Favaloro University, Institute of Cognitive Neurology (INECO), and Institute of Neurosciences, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kasten, Meike" sort="Kasten, Meike" uniqKey="Kasten M" first="Meike" last="Kasten">Meike Kasten</name>
<affiliation wicri:level="1"><nlm:aff id="A6">University of Lubeck, Department of Neurology, Lubeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Lubeck, Department of Neurology, Lubeck</wicri:regionArea>
<wicri:noRegion>Lubeck</wicri:noRegion>
<wicri:noRegion>Lubeck</wicri:noRegion>
<wicri:noRegion>Lubeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Priestley, Benjamin" sort="Priestley, Benjamin" uniqKey="Priestley B" first="Benjamin" last="Priestley">Benjamin Priestley</name>
<affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chou, Kelvin L" sort="Chou, Kelvin L" uniqKey="Chou K" first="Kelvin L" last="Chou">Kelvin L. Chou</name>
<affiliation wicri:level="2"><nlm:aff id="A7">University of Michigan Health System, Department of Neurology, Ann Arbor, MI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>University of Michigan Health System, Department of Neurology, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic, Center for Neurology Restoration, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic, Center for Neurology Restoration, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<affiliation wicri:level="2"><nlm:aff id="A9">University of Kentucky, Department of Neurology, Lexington, KY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>University of Kentucky, Department of Neurology, Lexington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Langston, J William" sort="Langston, J William" uniqKey="Langston J" first="J William" last="Langston">J William Langston</name>
<affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Annals of Neurology</title>
<idno type="ISSN">0364-5134</idno>
<idno type="eISSN">1531-8249</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">Several case reports have linked solvent exposure to Parkinson’s disease (PD), but few studies have assessed associations with specific agents using an analytic epidemiologic design. We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">99 twin pairs discordant for PD ascertained from the National Academy of Science/National Research Council (NAS/NRC) World War II Veteran Twins Cohort were interviewed regarding lifetime occupations and hobbies using detailed job-task-specific questionnaires. Exposures to 6 specific solvents selected <italic>a priori</italic>
 were estimated by expert raters unaware of case status.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Ever exposure to trichloroethylene (TCE) was associated with significantly increased risk of PD (OR 6.1, 95%CI 1.2 – 33; p = 0.034), and exposure to perchloroethylene (PERC) and carbon tetrachloride (CCl<sub>4</sub>
) tended toward significance (respectively: OR 10.5, 95%CI 0.97-113, p = 0.053; OR 2.3, 95%CI 0.9-6.1, p = 0.088). Results were similar for estimates of exposure duration and cumulative lifetime exposure.</p>
</sec>
<sec id="S4"><title>Interpretation</title>
<p id="P4">Exposure to specific solvents may increase risk of PD. TCE is the most common organic contaminant in groundwater, and PERC and CCl<sub>4</sub>
 are also ubiquitous in the environment. Our findings require replication in other populations with well-characterized exposures, but the potential public health implications are substantial.</p>
</sec>
</div>
</front>
</TEI>
</PMC>
</double>
</record>

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   |texte=   Solvent exposures and parkinson disease risk in twins
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La maladie de Parkinson au Canada (serveur d'exploration)

Solvent exposures and parkinson disease risk in twins

Solvent exposures and parkinson disease risk in twins

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	La maladie de Parkinson au Canada (serveur d'exploration)
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