Solvent Exposures and Parkinson’s Disease Risk in Twins
Identifieur interne : 000796 ( Pmc/Curation ); précédent : 000795; suivant : 000797Solvent Exposures and Parkinson’s Disease Risk in Twins
Auteurs : Samuel M. Goldman [États-Unis] ; Patricia J. Quinlan [États-Unis] ; G Webster Ross [États-Unis] ; Connie Marras [Canada] ; Cheryl Meng [États-Unis] ; Grace S. Bhudhikanok [États-Unis] ; Kathleen Comyns [États-Unis] ; Monica Korell [États-Unis] ; Anabel R. Chade [Argentine] ; Meike Kasten [Allemagne] ; Benjamin Priestley [États-Unis] ; Kelvin L. Chou [États-Unis] ; Hubert H. Fernandez [États-Unis] ; Franca Cambi [États-Unis] ; J William Langston [États-Unis] ; Caroline M. Tanner [États-Unis]Source :
- Annals of Neurology [ 0364-5134 ] ; 2011.
Abstract
Several case reports have linked solvent exposure to Parkinson’s disease (PD), but few studies have assessed associations with specific agents using an analytic epidemiologic design. We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design.
99 twin pairs discordant for PD ascertained from the National Academy of Science/National Research Council (NAS/NRC) World War II Veteran Twins Cohort were interviewed regarding lifetime occupations and hobbies using detailed job-task-specific questionnaires. Exposures to 6 specific solvents selected
Ever exposure to trichloroethylene (TCE) was associated with significantly increased risk of PD (OR 6.1, 95%CI 1.2 – 33; p = 0.034), and exposure to perchloroethylene (PERC) and carbon tetrachloride (CCl4) tended toward significance (respectively: OR 10.5, 95%CI 0.97-113, p = 0.053; OR 2.3, 95%CI 0.9-6.1, p = 0.088). Results were similar for estimates of exposure duration and cumulative lifetime exposure.
Exposure to specific solvents may increase risk of PD. TCE is the most common organic contaminant in groundwater, and PERC and CCl4 are also ubiquitous in the environment. Our findings require replication in other populations with well-characterized exposures, but the potential public health implications are substantial.
Url:
DOI: 10.1002/ana.22629
PubMed: 22083847
PubMed Central: 3366287
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000796
Links to Exploration step
PMC:3366287Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Solvent Exposures and Parkinson’s Disease Risk in Twins</title><author><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M" last="Goldman">Samuel M. Goldman</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Quinlan, Patricia J" sort="Quinlan, Patricia J" uniqKey="Quinlan P" first="Patricia J" last="Quinlan">Patricia J. Quinlan</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Medicine, Division of Occupational and Environmental Medicine, University of California, San Francisco, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Medicine, Division of Occupational and Environmental Medicine, University of California, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name><affiliation wicri:level="2"><nlm:aff id="A3">Veterans Affairs Pacific Islands Health Care System, Honolulu, HI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Veterans Affairs Pacific Islands Health Care System, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><affiliation wicri:level="1"><nlm:aff id="A4">Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Meng, Cheryl" sort="Meng, Cheryl" uniqKey="Meng C" first="Cheryl" last="Meng">Cheryl Meng</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Bhudhikanok, Grace S" sort="Bhudhikanok, Grace S" uniqKey="Bhudhikanok G" first="Grace S" last="Bhudhikanok">Grace S. Bhudhikanok</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Comyns, Kathleen" sort="Comyns, Kathleen" uniqKey="Comyns K" first="Kathleen" last="Comyns">Kathleen Comyns</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Korell, Monica" sort="Korell, Monica" uniqKey="Korell M" first="Monica" last="Korell">Monica Korell</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Chade, Anabel R" sort="Chade, Anabel R" uniqKey="Chade A" first="Anabel R" last="Chade">Anabel R. Chade</name><affiliation wicri:level="1"><nlm:aff id="A5">Favaloro University, Institute of Cognitive Neurology (INECO), and Institute of Neurosciences, Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Favaloro University, Institute of Cognitive Neurology (INECO), and Institute of Neurosciences, Buenos Aires</wicri:regionArea></affiliation></author><author><name sortKey="Kasten, Meike" sort="Kasten, Meike" uniqKey="Kasten M" first="Meike" last="Kasten">Meike Kasten</name><affiliation wicri:level="1"><nlm:aff id="A6">University of Lubeck, Department of Neurology, Lubeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Lubeck, Department of Neurology, Lubeck</wicri:regionArea></affiliation></author><author><name sortKey="Priestley, Benjamin" sort="Priestley, Benjamin" uniqKey="Priestley B" first="Benjamin" last="Priestley">Benjamin Priestley</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Chou, Kelvin L" sort="Chou, Kelvin L" uniqKey="Chou K" first="Kelvin L" last="Chou">Kelvin L. Chou</name><affiliation wicri:level="2"><nlm:aff id="A7">University of Michigan Health System, Department of Neurology, Ann Arbor, MI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>University of Michigan Health System, Department of Neurology, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name><affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic, Center for Neurology Restoration, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cleveland Clinic, Center for Neurology Restoration, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name><affiliation wicri:level="2"><nlm:aff id="A9">University of Kentucky, Department of Neurology, Lexington, KY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>University of Kentucky, Department of Neurology, Lexington</wicri:cityArea></affiliation></author><author><name sortKey="Langston, J William" sort="Langston, J William" uniqKey="Langston J" first="J William" last="Langston">J William Langston</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22083847</idno><idno type="pmc">3366287</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366287</idno><idno type="RBID">PMC:3366287</idno><idno type="doi">10.1002/ana.22629</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000796</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000796</idno><idno type="wicri:Area/Pmc/Curation">000796</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000796</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Solvent Exposures and Parkinson’s Disease Risk in Twins</title><author><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M" last="Goldman">Samuel M. Goldman</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Quinlan, Patricia J" sort="Quinlan, Patricia J" uniqKey="Quinlan P" first="Patricia J" last="Quinlan">Patricia J. Quinlan</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Medicine, Division of Occupational and Environmental Medicine, University of California, San Francisco, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Medicine, Division of Occupational and Environmental Medicine, University of California, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name><affiliation wicri:level="2"><nlm:aff id="A3">Veterans Affairs Pacific Islands Health Care System, Honolulu, HI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Veterans Affairs Pacific Islands Health Care System, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><affiliation wicri:level="1"><nlm:aff id="A4">Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Meng, Cheryl" sort="Meng, Cheryl" uniqKey="Meng C" first="Cheryl" last="Meng">Cheryl Meng</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Bhudhikanok, Grace S" sort="Bhudhikanok, Grace S" uniqKey="Bhudhikanok G" first="Grace S" last="Bhudhikanok">Grace S. Bhudhikanok</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Comyns, Kathleen" sort="Comyns, Kathleen" uniqKey="Comyns K" first="Kathleen" last="Comyns">Kathleen Comyns</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Korell, Monica" sort="Korell, Monica" uniqKey="Korell M" first="Monica" last="Korell">Monica Korell</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Chade, Anabel R" sort="Chade, Anabel R" uniqKey="Chade A" first="Anabel R" last="Chade">Anabel R. Chade</name><affiliation wicri:level="1"><nlm:aff id="A5">Favaloro University, Institute of Cognitive Neurology (INECO), and Institute of Neurosciences, Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Favaloro University, Institute of Cognitive Neurology (INECO), and Institute of Neurosciences, Buenos Aires</wicri:regionArea></affiliation></author><author><name sortKey="Kasten, Meike" sort="Kasten, Meike" uniqKey="Kasten M" first="Meike" last="Kasten">Meike Kasten</name><affiliation wicri:level="1"><nlm:aff id="A6">University of Lubeck, Department of Neurology, Lubeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Lubeck, Department of Neurology, Lubeck</wicri:regionArea></affiliation></author><author><name sortKey="Priestley, Benjamin" sort="Priestley, Benjamin" uniqKey="Priestley B" first="Benjamin" last="Priestley">Benjamin Priestley</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Chou, Kelvin L" sort="Chou, Kelvin L" uniqKey="Chou K" first="Kelvin L" last="Chou">Kelvin L. Chou</name><affiliation wicri:level="2"><nlm:aff id="A7">University of Michigan Health System, Department of Neurology, Ann Arbor, MI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>University of Michigan Health System, Department of Neurology, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name><affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic, Center for Neurology Restoration, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cleveland Clinic, Center for Neurology Restoration, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name><affiliation wicri:level="2"><nlm:aff id="A9">University of Kentucky, Department of Neurology, Lexington, KY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>University of Kentucky, Department of Neurology, Lexington</wicri:cityArea></affiliation></author><author><name sortKey="Langston, J William" sort="Langston, J William" uniqKey="Langston J" first="J William" last="Langston">J William Langston</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name><affiliation wicri:level="2"><nlm:aff id="A1">The Parkinson’s Institute, Sunnyvale, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea></affiliation></author></analytic><series><title level="j">Annals of Neurology</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">Several case reports have linked solvent exposure to Parkinson’s disease (PD), but few studies have assessed associations with specific agents using an analytic epidemiologic design. We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design.</p></sec><sec id="S2"><title>Methods</title><p id="P2">99 twin pairs discordant for PD ascertained from the National Academy of Science/National Research Council (NAS/NRC) World War II Veteran Twins Cohort were interviewed regarding lifetime occupations and hobbies using detailed job-task-specific questionnaires. Exposures to 6 specific solvents selected <italic>a priori</italic> were estimated by expert raters unaware of case status.</p></sec><sec id="S3"><title>Results</title><p id="P3">Ever exposure to trichloroethylene (TCE) was associated with significantly increased risk of PD (OR 6.1, 95%CI 1.2 – 33; p = 0.034), and exposure to perchloroethylene (PERC) and carbon tetrachloride (CCl<sub>4</sub>) tended toward significance (respectively: OR 10.5, 95%CI 0.97-113, p = 0.053; OR 2.3, 95%CI 0.9-6.1, p = 0.088). Results were similar for estimates of exposure duration and cumulative lifetime exposure.</p></sec><sec id="S4"><title>Interpretation</title><p id="P4">Exposure to specific solvents may increase risk of PD. TCE is the most common organic contaminant in groundwater, and PERC and CCl<sub>4</sub> are also ubiquitous in the environment. Our findings require replication in other populations with well-characterized exposures, but the potential public health implications are substantial.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7707449</journal-id><journal-id journal-id-type="pubmed-jr-id">656</journal-id><journal-id journal-id-type="nlm-ta">Ann Neurol</journal-id><journal-id journal-id-type="iso-abbrev">Ann. Neurol.</journal-id><journal-title-group><journal-title>Annals of Neurology</journal-title></journal-title-group><issn pub-type="ppub">0364-5134</issn><issn pub-type="epub">1531-8249</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22083847</article-id><article-id pub-id-type="pmc">3366287</article-id><article-id pub-id-type="doi">10.1002/ana.22629</article-id><article-id pub-id-type="manuscript">NIHMS323019</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Solvent Exposures and Parkinson’s Disease Risk in Twins</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Goldman</surname><given-names>Samuel M</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Quinlan</surname><given-names>Patricia J</given-names></name><degrees>MPH, CIH</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ross</surname><given-names>G Webster</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Marras</surname><given-names>Connie</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Meng</surname><given-names>Cheryl</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bhudhikanok</surname><given-names>Grace S</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Comyns</surname><given-names>Kathleen</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Korell</surname><given-names>Monica</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chade</surname><given-names>Anabel R</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Kasten</surname><given-names>Meike</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Priestley</surname><given-names>Benjamin</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chou</surname><given-names>Kelvin L</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Fernandez</surname><given-names>Hubert H</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Cambi</surname><given-names>Franca</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Langston</surname><given-names>J William</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tanner</surname><given-names>Caroline M</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>The Parkinson’s Institute, Sunnyvale, CA</aff><aff id="A2"><label>2</label>Department of Medicine, Division of Occupational and Environmental Medicine, University of California, San Francisco, CA</aff><aff id="A3"><label>3</label>Veterans Affairs Pacific Islands Health Care System, Honolulu, HI</aff><aff id="A4"><label>4</label>Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A5"><label>5</label>Favaloro University, Institute of Cognitive Neurology (INECO), and Institute of Neurosciences, Buenos Aires, Argentina</aff><aff id="A6"><label>6</label>University of Lubeck, Department of Neurology, Lubeck, Germany</aff><aff id="A7"><label>7</label>University of Michigan Health System, Department of Neurology, Ann Arbor, MI</aff><aff id="A8"><label>8</label>Cleveland Clinic, Center for Neurology Restoration, Cleveland, OH</aff><aff id="A9"><label>9</label>University of Kentucky, Department of Neurology, Lexington, KY</aff><author-notes><corresp id="CR1"><bold>Corresponding author</bold>: Samuel M Goldman, MD, MPH, Parkinson’s Institute, 675 Almanor Avenue, Sunnyvale, CA 94085, <bold>Corresponding author’s phone and fax</bold>: Phone- (408) 542-5618, Fax- (408) 734-8455, <bold>Corresponding author’s</bold>: <email>sgoldman@thepi.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>15</day><month>10</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>14</day><month>11</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>6</month><year>2013</year></pub-date><volume>71</volume><issue>6</issue><fpage>776</fpage><lpage>784</lpage><abstract><sec id="S1"><title>Objective</title><p id="P1">Several case reports have linked solvent exposure to Parkinson’s disease (PD), but few studies have assessed associations with specific agents using an analytic epidemiologic design. We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design.</p></sec><sec id="S2"><title>Methods</title><p id="P2">99 twin pairs discordant for PD ascertained from the National Academy of Science/National Research Council (NAS/NRC) World War II Veteran Twins Cohort were interviewed regarding lifetime occupations and hobbies using detailed job-task-specific questionnaires. Exposures to 6 specific solvents selected <italic>a priori</italic> were estimated by expert raters unaware of case status.</p></sec><sec id="S3"><title>Results</title><p id="P3">Ever exposure to trichloroethylene (TCE) was associated with significantly increased risk of PD (OR 6.1, 95%CI 1.2 – 33; p = 0.034), and exposure to perchloroethylene (PERC) and carbon tetrachloride (CCl<sub>4</sub>) tended toward significance (respectively: OR 10.5, 95%CI 0.97-113, p = 0.053; OR 2.3, 95%CI 0.9-6.1, p = 0.088). Results were similar for estimates of exposure duration and cumulative lifetime exposure.</p></sec><sec id="S4"><title>Interpretation</title><p id="P4">Exposure to specific solvents may increase risk of PD. TCE is the most common organic contaminant in groundwater, and PERC and CCl<sub>4</sub> are also ubiquitous in the environment. Our findings require replication in other populations with well-characterized exposures, but the potential public health implications are substantial.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000796 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000796 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:3366287
|texte= Solvent Exposures and Parkinson’s Disease Risk in Twins
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:22083847" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |