Biomarkers for trials of neuroprotection in Parkinson's disease
Identifieur interne : 001021 ( Main/Exploration ); précédent : 001020; suivant : 001022Biomarkers for trials of neuroprotection in Parkinson's disease
Auteurs : Pankaj A. Agarwal [Canada] ; A. Jon Stoessl [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2013-01.
English descriptors
- KwdEn :
- Animals, Biomarkers (metabolism), Brain (metabolism), Brain (pathology), Disease Progression, Dopamine (metabolism), Essential Tremor (diagnosis), Humans, Neuroimaging, Neuroprotective Agents (therapeutic use), Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (metabolism).
- MESH :
- chemical , metabolism : Biomarkers, Dopamine.
- diagnosis : Essential Tremor, Parkinson Disease.
- drug therapy : Parkinson Disease.
- metabolism : Brain, Parkinson Disease.
- pathology : Brain.
- chemical , therapeutic use : Neuroprotective Agents.
- Animals, Disease Progression, Humans, Neuroimaging.
Abstract
With increased understanding of disease pathogenesis and the foreseeable reality of disease‐modifying therapies, there is a growing need to find biomarkers that will allow early (preferably preclinical) detection of disease and that will provide an independent readout of disease progression. In this article, we review a variety of markers, with a focus on functional imaging techniques, which while imperfect, currently provide the best approach to this problem. We consider the limitations of functional imaging of the dopamine system in assessing the progression of Parkinson's Disease (PD) as well as the potential use of structural imaging and emerging progress in other biochemical and molecular markers. While there is no single biomarker that will satisfy all requirements, some combination is likely to be of great use in identifying those subjects most likely to benefit from neuroprotective therapies, as well as in monitoring the effects of these interventions. © 2013 Movement Disorder Society
Url:
DOI: 10.1002/mds.25065
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000152
- to stream Istex, to step Curation: 000152
- to stream Istex, to step Checkpoint: 000139
- to stream PubMed, to step Corpus: 000987
- to stream PubMed, to step Curation: 000987
- to stream PubMed, to step Checkpoint: 000987
- to stream Ncbi, to step Merge: 001233
- to stream Ncbi, to step Curation: 001233
- to stream Ncbi, to step Checkpoint: 001233
- to stream Main, to step Merge: 001033
- to stream Main, to step Curation: 001021
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Biomarkers for trials of neuroprotection in Parkinson's disease</title>
<author><name sortKey="Agarwal, Pankaj A" sort="Agarwal, Pankaj A" uniqKey="Agarwal P" first="Pankaj A." last="Agarwal">Pankaj A. Agarwal</name>
</author>
<author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:07F59C467FC0683976CDE07244A017B4B0867BCD</idno>
<date when="2013" year="2013">2013</date>
<idno type="doi">10.1002/mds.25065</idno>
<idno type="url">https://api-v5.istex.fr/document/07F59C467FC0683976CDE07244A017B4B0867BCD/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000152</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000152</idno>
<idno type="wicri:Area/Istex/Curation">000152</idno>
<idno type="wicri:Area/Istex/Checkpoint">000139</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000139</idno>
<idno type="wicri:doubleKey">0885-3185:2013:Agarwal P:biomarkers:for:trials</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:22927101</idno>
<idno type="wicri:Area/PubMed/Corpus">000987</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000987</idno>
<idno type="wicri:Area/PubMed/Curation">000987</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000987</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000987</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000987</idno>
<idno type="wicri:Area/Ncbi/Merge">001233</idno>
<idno type="wicri:Area/Ncbi/Curation">001233</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001233</idno>
<idno type="wicri:Area/Main/Merge">001033</idno>
<idno type="wicri:Area/Main/Curation">001021</idno>
<idno type="wicri:Area/Main/Exploration">001021</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Biomarkers for trials of neuroprotection in Parkinson's disease</title>
<author><name sortKey="Agarwal, Pankaj A" sort="Agarwal, Pankaj A" uniqKey="Agarwal P" first="Pankaj A." last="Agarwal">Pankaj A. Agarwal</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Pacific Parkinson's Research Centre, University of British Columbia, British Columbia, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, British Columbia</wicri:regionArea>
<wicri:noRegion>British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Vancouver Costal Health, British Columbia, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Canada</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov Disord</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Blackwell Publishing Ltd</publisher>
<date type="published" when="2013-01">2013-01</date>
<biblScope unit="volume">28</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="71">71</biblScope>
<biblScope unit="page" to="85">85</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">07F59C467FC0683976CDE07244A017B4B0867BCD</idno>
<idno type="DOI">10.1002/mds.25065</idno>
<idno type="ArticleID">MDS25065</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Biomarkers (metabolism)</term>
<term>Brain (metabolism)</term>
<term>Brain (pathology)</term>
<term>Disease Progression</term>
<term>Dopamine (metabolism)</term>
<term>Essential Tremor (diagnosis)</term>
<term>Humans</term>
<term>Neuroimaging</term>
<term>Neuroprotective Agents (therapeutic use)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term>
<term>Dopamine</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Essential Tremor</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Neuroprotective Agents</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Progression</term>
<term>Humans</term>
<term>Neuroimaging</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract">With increased understanding of disease pathogenesis and the foreseeable reality of disease‐modifying therapies, there is a growing need to find biomarkers that will allow early (preferably preclinical) detection of disease and that will provide an independent readout of disease progression. In this article, we review a variety of markers, with a focus on functional imaging techniques, which while imperfect, currently provide the best approach to this problem. We consider the limitations of functional imaging of the dopamine system in assessing the progression of Parkinson's Disease (PD) as well as the potential use of structural imaging and emerging progress in other biochemical and molecular markers. While there is no single biomarker that will satisfy all requirements, some combination is likely to be of great use in identifying those subjects most likely to benefit from neuroprotective therapies, as well as in monitoring the effects of these interventions. © 2013 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Agarwal, Pankaj A" sort="Agarwal, Pankaj A" uniqKey="Agarwal P" first="Pankaj A." last="Agarwal">Pankaj A. Agarwal</name>
</noRegion>
<name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name>
<name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name>
<name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001021 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001021 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:07F59C467FC0683976CDE07244A017B4B0867BCD |texte= Biomarkers for trials of neuroprotection in Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |