Biomarkers for trials of neuroprotection in Parkinson's disease
Identifieur interne : 000152 ( Istex/Corpus ); précédent : 000151; suivant : 000153Biomarkers for trials of neuroprotection in Parkinson's disease
Auteurs : Pankaj A. Agarwal ; A. Jon StoesslSource :
- Movement Disorders [ 0885-3185 ] ; 2013-01.
Abstract
With increased understanding of disease pathogenesis and the foreseeable reality of disease‐modifying therapies, there is a growing need to find biomarkers that will allow early (preferably preclinical) detection of disease and that will provide an independent readout of disease progression. In this article, we review a variety of markers, with a focus on functional imaging techniques, which while imperfect, currently provide the best approach to this problem. We consider the limitations of functional imaging of the dopamine system in assessing the progression of Parkinson's Disease (PD) as well as the potential use of structural imaging and emerging progress in other biochemical and molecular markers. While there is no single biomarker that will satisfy all requirements, some combination is likely to be of great use in identifying those subjects most likely to benefit from neuroprotective therapies, as well as in monitoring the effects of these interventions. © 2013 Movement Disorder Society
Url:
DOI: 10.1002/mds.25065
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<front><div type="abstract">With increased understanding of disease pathogenesis and the foreseeable reality of disease‐modifying therapies, there is a growing need to find biomarkers that will allow early (preferably preclinical) detection of disease and that will provide an independent readout of disease progression. In this article, we review a variety of markers, with a focus on functional imaging techniques, which while imperfect, currently provide the best approach to this problem. We consider the limitations of functional imaging of the dopamine system in assessing the progression of Parkinson's Disease (PD) as well as the potential use of structural imaging and emerging progress in other biochemical and molecular markers. While there is no single biomarker that will satisfy all requirements, some combination is likely to be of great use in identifying those subjects most likely to benefit from neuroprotective therapies, as well as in monitoring the effects of these interventions. © 2013 Movement Disorder Society</div>
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<affiliationGroup><affiliation type="organization" xml:id="mds25065-aff-0001" countryCode="CA"><orgDiv>Pacific Parkinson's Research Centre</orgDiv>
<orgName>University of British Columbia</orgName>
<address><city>Vancouver</city>
<countryPart>British Columbia</countryPart>
<country>Canada</country>
</address>
</affiliation>
<affiliation type="organization" xml:id="mds25065-aff-0002" countryCode="CA"><orgName>Vancouver Costal Health</orgName>
<address><city>Vancouver</city>
<countryPart>British Columbia</countryPart>
<country>Canada</country>
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</affiliationGroup>
<abstractGroup><abstract type="main"><p>With increased understanding of disease pathogenesis and the foreseeable reality of disease‐modifying therapies, there is a growing need to find biomarkers that will allow early (preferably preclinical) detection of disease and that will provide an independent readout of disease progression. In this article, we review a variety of markers, with a focus on functional imaging techniques, which while imperfect, currently provide the best approach to this problem. We consider the limitations of functional imaging of the dopamine system in assessing the progression of Parkinson's Disease (PD) as well as the potential use of structural imaging and emerging progress in other biochemical and molecular markers. While there is no single biomarker that will satisfy all requirements, some combination is likely to be of great use in identifying those subjects most likely to benefit from neuroprotective therapies, as well as in monitoring the effects of these interventions. © 2013 Movement Disorder Society</p>
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<noteGroup><note xml:id="mds25065-note-0001"><p><b>Funding agencies</b>
: The work of A.J.S. is supported by the Canadian Institutes of Health Research, the Michael J. Fox Foundation, the Pacific Alzheimer Research Foundation, and the Canada Research Chairs program.</p>
</note>
<note xml:id="mds25065-note-0002"><p><b>Relevant conflicts of interest/financial disclosure</b>
: Nothing to report.</p>
</note>
<note xml:id="mds25065-note-0003"><p>Full financial disclosures and author roles may be found in the online version of this article.</p>
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<mods version="3.6"><titleInfo lang="en"><title>Biomarkers for trials of neuroprotection in Parkinson's disease</title>
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<titleInfo type="abbreviated" lang="en"><title>Biomarkers of Neuroprotection in PD</title>
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<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Biomarkers for trials of neuroprotection in Parkinson's disease</title>
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<name type="personal"><namePart type="given">Pankaj A.</namePart>
<namePart type="family">Agarwal</namePart>
<namePart type="termsOfAddress">MD, DNB, DM</namePart>
<affiliation>Pacific Parkinson's Research Centre, University of British Columbia, British Columbia, Vancouver, Canada</affiliation>
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<name type="personal"><namePart type="given">A. Jon</namePart>
<namePart type="family">Stoessl</namePart>
<namePart type="termsOfAddress">CM, MD, FRCPC</namePart>
<affiliation>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, British Columbia, Canada</affiliation>
<affiliation>Vancouver Costal Health, British Columbia, Vancouver, Canada</affiliation>
<affiliation>E-mail: jstoessl@mail.ubc.ca</affiliation>
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<originInfo><publisher>Blackwell Publishing Ltd</publisher>
<dateIssued encoding="w3cdtf">2013-01</dateIssued>
<dateCreated encoding="w3cdtf">2013-02-06</dateCreated>
<dateCaptured encoding="w3cdtf">2012-01-18</dateCaptured>
<dateValid encoding="w3cdtf">2012-04-23</dateValid>
<copyrightDate encoding="w3cdtf">2013</copyrightDate>
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<abstract>With increased understanding of disease pathogenesis and the foreseeable reality of disease‐modifying therapies, there is a growing need to find biomarkers that will allow early (preferably preclinical) detection of disease and that will provide an independent readout of disease progression. In this article, we review a variety of markers, with a focus on functional imaging techniques, which while imperfect, currently provide the best approach to this problem. We consider the limitations of functional imaging of the dopamine system in assessing the progression of Parkinson's Disease (PD) as well as the potential use of structural imaging and emerging progress in other biochemical and molecular markers. While there is no single biomarker that will satisfy all requirements, some combination is likely to be of great use in identifying those subjects most likely to benefit from neuroprotective therapies, as well as in monitoring the effects of these interventions. © 2013 Movement Disorder Society</abstract>
<relatedItem type="host"><titleInfo><title>Movement Disorders</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Mov Disord</title>
</titleInfo>
<genre type="journal">journal</genre>
<subject><genre>article-category</genre>
<topic>Review</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2013</date>
<detail type="title"><title>The Vatican Conference on Neuroprotection in Parkinson's Disease</title>
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<detail type="volume"><caption>vol.</caption>
<number>28</number>
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<detail type="issue"><caption>no.</caption>
<number>1</number>
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<extent unit="pages"><start>71</start>
<end>85</end>
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