ParkinsonCanadaV1, Main, Exploration, bibRecord, 002F01

Subthalamic deep brain stimulation does not induce striatal dopamine release in Parkinson's disease

Identifieur interne : 002F01 ( Main/Exploration ); précédent : 002F00; suivant : 002F02

Subthalamic deep brain stimulation does not induce striatal dopamine release in Parkinson's disease

Auteurs : Antonio P. Strafella [Canada] ; Abbas F. Sadikot [Canada] ; Alain Dagher [Canada]

Source :

Neuroreport : (Oxford) [ 0959-4965 ] ; 2003.

RBID : Pascal:03-0450983

Descripteurs français

Pascal (Inist)
- Corps strié, Dopamine, Libération, Noyau sousthalamique, Stimulation, Parkinson maladie, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Corpus Striatum (metabolism), Corpus Striatum (secretion), Corpus striatum, Dopamine, Dopamine (metabolism), Dopamine (secretion), Electric Stimulation Therapy (methods), Extracellular Space (metabolism), Human, Humans, Middle Aged, Parkinson Disease (metabolism), Parkinson Disease (therapy), Parkinson disease, Release, Stimulation, Subthalamic Nucleus (metabolism), Subthalamic Nucleus (secretion), Subthalamic nucleus.
MESH :
- chemical , metabolism : Dopamine.
- metabolism : Corpus Striatum, Extracellular Space, Parkinson Disease, Subthalamic Nucleus.
- methods : Electric Stimulation Therapy.
- secretion : Corpus Striatum, Dopamine, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Aged, Humans, Middle Aged.

Abstract

Deep brain stimulation of the subthalamic nucleus (STN) is an increasingly prevalent treatment for advanced Parkinson's disease (PD). Its main mechanism of action is thought to be a reduction in the inhibitory outflow from basal ganglia to cerebral cortex. However, recent animal experiments have led to the suggestion that high frequency stimulation of the STN also acts by promoting dopamine release. We tested this hypothesis by performing [¹¹C]raclopride PET on and off stimulation in six patients with PD and implanted STN stimulators. There was no difference in tracer binding in the striatum between the two testing conditions. We conclude that high frequency stimulation of the STN does not act by increasing dopamine release.

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Deep brain stimulation of the subthalamic nucleus (STN) is an increasingly prevalent treatment for advanced Parkinson's disease (PD). Its main mechanism of action is thought to be a reduction in the inhibitory outflow from basal ganglia to cerebral cortex. However, recent animal experiments have led to the suggestion that high frequency stimulation of the STN also acts by promoting dopamine release. We tested this hypothesis by performing [<sup>11</sup>
C]raclopride PET on and off stimulation in six patients with PD and implanted STN stimulators. There was no difference in tracer binding in the striatum between the two testing conditions. We conclude that high frequency stimulation of the STN does not act by increasing dopamine release.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Subthalamic deep brain stimulation does not induce striatal dopamine release in Parkinson's disease

Subthalamic deep brain stimulation does not induce striatal dopamine release in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.