Subthalamic deep brain stimulation does not induce striatal dopamine release in Parkinson's disease.
Identifieur interne : 000314 ( Ncbi/Curation ); précédent : 000313; suivant : 000315Subthalamic deep brain stimulation does not induce striatal dopamine release in Parkinson's disease.
Auteurs : Antonio P. Strafella [Canada] ; Abbas F. Sadikot ; Alain DagherSource :
- Neuroreport [ 0959-4965 ] ; 2003.
English descriptors
- KwdEn :
- Aged, Corpus Striatum (metabolism), Corpus Striatum (secretion), Dopamine (metabolism), Dopamine (secretion), Electric Stimulation Therapy (methods), Extracellular Space (metabolism), Humans, Middle Aged, Parkinson Disease (metabolism), Parkinson Disease (therapy), Subthalamic Nucleus (metabolism), Subthalamic Nucleus (secretion).
- MESH :
- chemical , metabolism : Dopamine.
- metabolism : Corpus Striatum, Extracellular Space, Parkinson Disease, Subthalamic Nucleus.
- methods : Electric Stimulation Therapy.
- secretion : Corpus Striatum, Dopamine, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Aged, Humans, Middle Aged.
Abstract
Deep brain stimulation of the subthalamic nucleus (STN) is an increasingly prevalent treatment for advanced Parkinson's disease (PD). Its main mechanism of action is thought to be a reduction in the inhibitory outflow from basal ganglia to cerebral cortex. However, recent animal experiments have led to the suggestion that high frequency stimulation of the STN also acts by promoting dopamine release. We tested this hypothesis by performing [11C]raclopride PET on and off stimulation in six patients with PD and implanted STN stimulators. There was no difference in tracer binding in the striatum between the two testing conditions. We conclude that high frequency stimulation of the STN does not act by increasing dopamine release.
DOI: 10.1097/01.wnr.0000081873.45938.56
PubMed: 12824777
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pubmed:12824777Le document en format XML
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Sadikot</name></author><author><name sortKey="Dagher, Alain" sort="Dagher, Alain" uniqKey="Dagher A" first="Alain" last="Dagher">Alain Dagher</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12824777</idno><idno type="pmid">12824777</idno><idno type="doi">10.1097/01.wnr.0000081873.45938.56</idno><idno type="wicri:Area/PubMed/Corpus">001426</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001426</idno><idno type="wicri:Area/PubMed/Curation">001426</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001426</idno><idno type="wicri:Area/PubMed/Checkpoint">001426</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001426</idno><idno type="wicri:Area/Ncbi/Merge">000314</idno><idno type="wicri:Area/Ncbi/Curation">000314</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Subthalamic deep brain stimulation does not induce striatal dopamine release in Parkinson's disease.</title><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name><affiliation wicri:level="4"><nlm:affiliation>Montreal Neurological Institute, McGill University, Montréal, Québec, Canada. antonio@bic.mni.mcgill.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Neurological Institute, McGill University, Montréal, Québec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Sadikot, Abbas F" sort="Sadikot, Abbas F" uniqKey="Sadikot A" first="Abbas F" last="Sadikot">Abbas F. Sadikot</name></author><author><name sortKey="Dagher, Alain" sort="Dagher, Alain" uniqKey="Dagher A" first="Alain" last="Dagher">Alain Dagher</name></author></analytic><series><title level="j">Neuroreport</title><idno type="ISSN">0959-4965</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (secretion)</term><term>Dopamine (metabolism)</term><term>Dopamine (secretion)</term><term>Electric Stimulation Therapy (methods)</term><term>Extracellular Space (metabolism)</term><term>Humans</term><term>Middle Aged</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (therapy)</term><term>Subthalamic Nucleus (metabolism)</term><term>Subthalamic Nucleus (secretion)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Extracellular Space</term><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation Therapy</term></keywords><keywords scheme="MESH" qualifier="secretion" xml:lang="en"><term>Corpus Striatum</term><term>Dopamine</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation of the subthalamic nucleus (STN) is an increasingly prevalent treatment for advanced Parkinson's disease (PD). Its main mechanism of action is thought to be a reduction in the inhibitory outflow from basal ganglia to cerebral cortex. However, recent animal experiments have led to the suggestion that high frequency stimulation of the STN also acts by promoting dopamine release. We tested this hypothesis by performing [11C]raclopride PET on and off stimulation in six patients with PD and implanted STN stimulators. There was no difference in tracer binding in the striatum between the two testing conditions. We conclude that high frequency stimulation of the STN does not act by increasing dopamine release.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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