ParkinsonCanadaV1, Main, Exploration, bibRecord, 001D42

Apomorphine reduces subthalamic neuronal entropy in parkinsonian patients

Identifieur interne : 001D42 ( Main/Exploration ); précédent : 001D41; suivant : 001D43

Apomorphine reduces subthalamic neuronal entropy in parkinsonian patients

Auteurs : M. Lafreniere-Roula [Canada] ; O. Darbin [États-Unis] ; W. D. Hutchison [Canada] ; T. Wichmann [États-Unis] ; A. M. Lozano [Canada] ; J. O. Dostrovsky [Canada]

Source :

Experimental neurology : (Print) [ 0014-4886 ] ; 2010.

RBID : Pascal:10-0478009

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Apomorphine, Entropie, Homme, Non linéarité, Mode décharge.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Action Potentials (drug effects), Apomorphine (therapeutic use), Deep Brain Stimulation, Discharge pattern, Entropy, Human, Humans, Nervous system diseases, Neurons (drug effects), Nonlinearity, Parkinson Disease (drug therapy), Parkinson disease, Subthalamic Nucleus (drug effects).
MESH :
- chemical , therapeutic use : Apomorphine.
- drug effects : Action Potentials, Neurons, Subthalamic Nucleus.
- drug therapy : Parkinson Disease.
- Deep Brain Stimulation, Entropy, Humans.

Abstract

Dopamine depletion in Parkinson's disease (PD) alters the neuronal activity in basal ganglia circuits. Characterizing these changes in network activity is an important step in understanding the disease and how therapies mitigate symptoms. Non-linear analysis methods can complement the traditional description of neuronal firing characteristics. Here we examine the entropy of subthalamic neurons in PD patients undergoing stereotactic surgery for deep brain stimulation (DBS). The activity of 8 neurons was recorded prior to, during, and following systemic administration of the dopamine agonist apomorphine at clinically effective doses. Apomorphine induced a decrease in entropy measured in the inter-spike intervals of subthalamic neurons in 6 of the 8 neurons. This is the first report that anti-parkinsonian drugs affect non-linear features of neuronal firing in the basal ganglia of parkinsonian patients.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939318

Affiliations:

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<front><div type="abstract" xml:lang="en">Dopamine depletion in Parkinson's disease (PD) alters the neuronal activity in basal ganglia circuits. Characterizing these changes in network activity is an important step in understanding the disease and how therapies mitigate symptoms. Non-linear analysis methods can complement the traditional description of neuronal firing characteristics. Here we examine the entropy of subthalamic neurons in PD patients undergoing stereotactic surgery for deep brain stimulation (DBS). The activity of 8 neurons was recorded prior to, during, and following systemic administration of the dopamine agonist apomorphine at clinically effective doses. Apomorphine induced a decrease in entropy measured in the inter-spike intervals of subthalamic neurons in 6 of the 8 neurons. This is the first report that anti-parkinsonian drugs affect non-linear features of neuronal firing in the basal ganglia of parkinsonian patients.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Apomorphine reduces subthalamic neuronal entropy in parkinsonian patients

Apomorphine reduces subthalamic neuronal entropy in parkinsonian patients

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.