Apomorphine reduces subthalamic neuronal entropy in parkinsonian patients
Identifieur interne : 001D42 ( Main/Exploration ); précédent : 001D41; suivant : 001D43Apomorphine reduces subthalamic neuronal entropy in parkinsonian patients
Auteurs : M. Lafreniere-Roula [Canada] ; O. Darbin [États-Unis] ; W. D. Hutchison [Canada] ; T. Wichmann [États-Unis] ; A. M. Lozano [Canada] ; J. O. Dostrovsky [Canada]Source :
- Experimental neurology : (Print) [ 0014-4886 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Apomorphine.
- drug effects : Action Potentials, Neurons, Subthalamic Nucleus.
- drug therapy : Parkinson Disease.
- Deep Brain Stimulation, Entropy, Humans.
Abstract
Dopamine depletion in Parkinson's disease (PD) alters the neuronal activity in basal ganglia circuits. Characterizing these changes in network activity is an important step in understanding the disease and how therapies mitigate symptoms. Non-linear analysis methods can complement the traditional description of neuronal firing characteristics. Here we examine the entropy of subthalamic neurons in PD patients undergoing stereotactic surgery for deep brain stimulation (DBS). The activity of 8 neurons was recorded prior to, during, and following systemic administration of the dopamine agonist apomorphine at clinically effective doses. Apomorphine induced a decrease in entropy measured in the inter-spike intervals of subthalamic neurons in 6 of the 8 neurons. This is the first report that anti-parkinsonian drugs affect non-linear features of neuronal firing in the basal ganglia of parkinsonian patients.
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Affiliations:
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Le document en format XML
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<term>Human</term>
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<front><div type="abstract" xml:lang="en">Dopamine depletion in Parkinson's disease (PD) alters the neuronal activity in basal ganglia circuits. Characterizing these changes in network activity is an important step in understanding the disease and how therapies mitigate symptoms. Non-linear analysis methods can complement the traditional description of neuronal firing characteristics. Here we examine the entropy of subthalamic neurons in PD patients undergoing stereotactic surgery for deep brain stimulation (DBS). The activity of 8 neurons was recorded prior to, during, and following systemic administration of the dopamine agonist apomorphine at clinically effective doses. Apomorphine induced a decrease in entropy measured in the inter-spike intervals of subthalamic neurons in 6 of the 8 neurons. This is the first report that anti-parkinsonian drugs affect non-linear features of neuronal firing in the basal ganglia of parkinsonian patients.</div>
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