Apomorphine reduces subthalamic neuronal entropy in parkinsonian patients.
Identifieur interne : 000C96 ( PubMed/Corpus ); précédent : 000C95; suivant : 000C97Apomorphine reduces subthalamic neuronal entropy in parkinsonian patients.
Auteurs : M. Lafreniere-Roula ; O. Darbin ; W D Hutchison ; T. Wichmann ; A M Lozano ; J O DostrovskySource :
- Experimental neurology [ 1090-2430 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Apomorphine.
- drug effects : Action Potentials, Neurons, Subthalamic Nucleus.
- drug therapy : Parkinson Disease.
- Deep Brain Stimulation, Entropy, Humans.
Abstract
Dopamine depletion in Parkinson's disease (PD) alters the neuronal activity in basal ganglia circuits. Characterizing these changes in network activity is an important step in understanding the disease and how therapies mitigate symptoms. Non-linear analysis methods can complement the traditional description of neuronal firing characteristics. Here we examine the entropy of subthalamic neurons in PD patients undergoing stereotactic surgery for deep brain stimulation (DBS). The activity of 8 neurons was recorded prior to, during, and following systemic administration of the dopamine agonist apomorphine at clinically effective doses. Apomorphine induced a decrease in entropy measured in the inter-spike intervals of sub-thalamic neurons in 6 of the 8 neurons. This is the first report that anti-parkinsonian drugs affect non-linear features of neuronal firing in the basal ganglia of parkinsonian patients.
DOI: 10.1016/j.expneurol.2010.07.016
PubMed: 20659454
Links to Exploration step
pubmed:20659454Le document en format XML
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<author><name sortKey="Lafreniere Roula, M" sort="Lafreniere Roula, M" uniqKey="Lafreniere Roula M" first="M" last="Lafreniere-Roula">M. Lafreniere-Roula</name>
<affiliation><nlm:affiliation>Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada. myriam.lafreniere.roula@utoronto.ca</nlm:affiliation>
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<author><name sortKey="Darbin, O" sort="Darbin, O" uniqKey="Darbin O" first="O" last="Darbin">O. Darbin</name>
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<author><name sortKey="Hutchison, W D" sort="Hutchison, W D" uniqKey="Hutchison W" first="W D" last="Hutchison">W D Hutchison</name>
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<author><name sortKey="Wichmann, T" sort="Wichmann, T" uniqKey="Wichmann T" first="T" last="Wichmann">T. Wichmann</name>
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<author><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A M" last="Lozano">A M Lozano</name>
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<author><name sortKey="Dostrovsky, J O" sort="Dostrovsky, J O" uniqKey="Dostrovsky J" first="J O" last="Dostrovsky">J O Dostrovsky</name>
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<author><name sortKey="Lafreniere Roula, M" sort="Lafreniere Roula, M" uniqKey="Lafreniere Roula M" first="M" last="Lafreniere-Roula">M. Lafreniere-Roula</name>
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<author><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A M" last="Lozano">A M Lozano</name>
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<term>Neurons (drug effects)</term>
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<front><div type="abstract" xml:lang="en">Dopamine depletion in Parkinson's disease (PD) alters the neuronal activity in basal ganglia circuits. Characterizing these changes in network activity is an important step in understanding the disease and how therapies mitigate symptoms. Non-linear analysis methods can complement the traditional description of neuronal firing characteristics. Here we examine the entropy of subthalamic neurons in PD patients undergoing stereotactic surgery for deep brain stimulation (DBS). The activity of 8 neurons was recorded prior to, during, and following systemic administration of the dopamine agonist apomorphine at clinically effective doses. Apomorphine induced a decrease in entropy measured in the inter-spike intervals of sub-thalamic neurons in 6 of the 8 neurons. This is the first report that anti-parkinsonian drugs affect non-linear features of neuronal firing in the basal ganglia of parkinsonian patients.</div>
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<Abstract><AbstractText>Dopamine depletion in Parkinson's disease (PD) alters the neuronal activity in basal ganglia circuits. Characterizing these changes in network activity is an important step in understanding the disease and how therapies mitigate symptoms. Non-linear analysis methods can complement the traditional description of neuronal firing characteristics. Here we examine the entropy of subthalamic neurons in PD patients undergoing stereotactic surgery for deep brain stimulation (DBS). The activity of 8 neurons was recorded prior to, during, and following systemic administration of the dopamine agonist apomorphine at clinically effective doses. Apomorphine induced a decrease in entropy measured in the inter-spike intervals of sub-thalamic neurons in 6 of the 8 neurons. This is the first report that anti-parkinsonian drugs affect non-linear features of neuronal firing in the basal ganglia of parkinsonian patients.</AbstractText>
<CopyrightInformation>Copyright © 2010 Elsevier Inc. All rights reserved.</CopyrightInformation>
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