Neural stem cell‐based treatment for neurodegenerative diseases
Identifieur interne : 000F68 ( Main/Exploration ); précédent : 000F67; suivant : 000F69Neural stem cell‐based treatment for neurodegenerative diseases
Auteurs : Seung U. Kim [Corée du Sud, Canada] ; Hong J. Lee [Corée du Sud, Canada] ; Yun B. Kim [Corée du Sud]Source :
- Neuropathology [ 0919-6544 ] ; 2013-10.
English descriptors
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- MESH :
Abstract
Human neurodegenrative diseases such as Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) are caused by a loss of neurons and glia in the brain or spinal cord. Neurons and glial cells have successfully been generated from stem cells such as embryonic stem cells (ESCs), mesenchymal stem cells (MSCs) and neural stem cells (NSCs), and stem cell‐based cell therapies for neurodegenerative diseases have been developed. A recent advance in generatioin of a new class of pluripotent stem cells, induced pluripotent stem cells (iPSCs), derived from patients' own skin fibroblasts, opens doors for a totally new field of personalized medicine. Transplantation of NSCs, neurons or glia generated from stem cells in animal models of neurodegenrative diseases, including PD, HD, ALS and AD, demonstrates clinical improvement and also life extension of these animals. Additional therapeutic benefits in these animals can be provided by stem cell‐mediated gene transfer of therapeutic genes such as neurotrophic factors and enzymes. Although further research is still needed, cell and gene therapy based on stem cells, particularly using neurons and glia derived from iPSCs, ESCs or NSCs, will become a routine treatment for patients suffering from neurodegenerative diseases and also stroke and spinal cord injury.
Url:
DOI: 10.1111/neup.12020
Affiliations:
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Lee</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Medical Research Institute, Chung‐Ang University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Yun B" sort="Kim, Yun B" uniqKey="Kim Y" first="Yun B." last="Kim">Yun B. Kim</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Toxiology, Chungbuk National University School of Vetrinary Medicine, Cheungju</wicri:regionArea><wicri:noRegion>Cheungju</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuropathology</title><title level="j" type="abbrev">Neuropathology</title><idno type="ISSN">0919-6544</idno><idno type="eISSN">1440-1789</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-10">2013-10</date><biblScope unit="volume">33</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="491">491</biblScope><biblScope unit="page" to="504">504</biblScope></imprint><idno type="ISSN">0919-6544</idno></series><idno type="istex">FD44E2C1C891DDFEF1724AD059A77AD6280120F6</idno><idno type="DOI">10.1111/neup.12020</idno><idno type="ArticleID">NEUP12020</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0919-6544</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (therapy)</term><term>Amyotrophic Lateral Sclerosis (therapy)</term><term>Animals</term><term>Cell- and Tissue-Based Therapy</term><term>Humans</term><term>Huntington Disease (therapy)</term><term>Neural Stem Cells (transplantation)</term><term>Neurodegenerative Diseases (therapy)</term><term>Parkinson Disease (therapy)</term><term>Stem Cell Transplantation</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Alzheimer Disease</term><term>Amyotrophic Lateral Sclerosis</term><term>Huntington Disease</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Neural Stem Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell- and Tissue-Based Therapy</term><term>Humans</term><term>Stem Cell Transplantation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Human neurodegenrative diseases such as Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) are caused by a loss of neurons and glia in the brain or spinal cord. Neurons and glial cells have successfully been generated from stem cells such as embryonic stem cells (ESCs), mesenchymal stem cells (MSCs) and neural stem cells (NSCs), and stem cell‐based cell therapies for neurodegenerative diseases have been developed. A recent advance in generatioin of a new class of pluripotent stem cells, induced pluripotent stem cells (iPSCs), derived from patients' own skin fibroblasts, opens doors for a totally new field of personalized medicine. Transplantation of NSCs, neurons or glia generated from stem cells in animal models of neurodegenrative diseases, including PD, HD, ALS and AD, demonstrates clinical improvement and also life extension of these animals. Additional therapeutic benefits in these animals can be provided by stem cell‐mediated gene transfer of therapeutic genes such as neurotrophic factors and enzymes. Although further research is still needed, cell and gene therapy based on stem cells, particularly using neurons and glia derived from iPSCs, ESCs or NSCs, will become a routine treatment for patients suffering from neurodegenerative diseases and also stroke and spinal cord injury.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kim, Seung U" sort="Kim, Seung U" uniqKey="Kim S" first="Seung U." last="Kim">Seung U. Kim</name></noRegion><name sortKey="Kim, Yun B" sort="Kim, Yun B" uniqKey="Kim Y" first="Yun B." last="Kim">Yun B. Kim</name><name sortKey="Lee, Hong J" sort="Lee, Hong J" uniqKey="Lee H" first="Hong J." last="Lee">Hong J. Lee</name></country><country name="Canada"><noRegion><name sortKey="Kim, Seung U" sort="Kim, Seung U" uniqKey="Kim S" first="Seung U." last="Kim">Seung U. Kim</name></noRegion><name sortKey="Kim, Seung U" sort="Kim, Seung U" uniqKey="Kim S" first="Seung U." last="Kim">Seung U. Kim</name><name sortKey="Lee, Hong J" sort="Lee, Hong J" uniqKey="Lee H" first="Hong J." last="Lee">Hong J. Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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