ParkinsonCanadaV1, Ncbi, Merge, bibRecord, 001381

Neural stem cell-based treatment for neurodegenerative diseases.

Identifieur interne : 001381 ( Ncbi/Merge ); précédent : 001380; suivant : 001382

Neural stem cell-based treatment for neurodegenerative diseases.

Auteurs : Seung U. Kim [Canada] ; Hong J. Lee ; Yun B. Kim

Source :

Neuropathology : official journal of the Japanese Society of Neuropathology [ 1440-1789 ] ; 2013.

RBID : pubmed:23384285

English descriptors

KwdEn :
- Alzheimer Disease (therapy), Amyotrophic Lateral Sclerosis (therapy), Animals, Cell- and Tissue-Based Therapy, Humans, Huntington Disease (therapy), Neural Stem Cells (transplantation), Neurodegenerative Diseases (therapy), Parkinson Disease (therapy), Stem Cell Transplantation.
MESH :
- therapy : Alzheimer Disease, Amyotrophic Lateral Sclerosis, Huntington Disease, Neurodegenerative Diseases, Parkinson Disease.
- transplantation : Neural Stem Cells.
- Animals, Cell- and Tissue-Based Therapy, Humans, Stem Cell Transplantation.

Abstract

Human neurodegenerative diseases such as Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) are caused by a loss of neurons and glia in the brain or spinal cord. Neurons and glial cells have successfully been generated from stem cells such as embryonic stem cells (ESCs), mesenchymal stem cells (MSCs) and neural stem cells (NSCs), and stem cell-based cell therapies for neurodegenerative diseases have been developed. A recent advance in generation of a new class of pluripotent stem cells, induced pluripotent stem cells (iPSCs), derived from patients' own skin fibroblasts, opens doors for a totally new field of personalized medicine. Transplantation of NSCs, neurons or glia generated from stem cells in animal models of neurodegenerative diseases, including PD, HD, ALS and AD, demonstrates clinical improvement and also life extension of these animals. Additional therapeutic benefits in these animals can be provided by stem cell-mediated gene transfer of therapeutic genes such as neurotrophic factors and enzymes. Although further research is still needed, cell and gene therapy based on stem cells, particularly using neurons and glia derived from iPSCs, ESCs or NSCs, will become a routine treatment for patients suffering from neurodegenerative diseases and also stroke and spinal cord injury.

DOI: 10.1111/neup.12020
PubMed: 23384285

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pubmed:23384285

Le document en format XML

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<wicri:regionArea>Medical Research Institute, Chung-Ang University College of Medicine, Seoul, Korea; Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, British Columbia</wicri:regionArea>
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<front><div type="abstract" xml:lang="en">Human neurodegenerative diseases such as Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) are caused by a loss of neurons and glia in the brain or spinal cord. Neurons and glial cells have successfully been generated from stem cells such as embryonic stem cells (ESCs), mesenchymal stem cells (MSCs) and neural stem cells (NSCs), and stem cell-based cell therapies for neurodegenerative diseases have been developed. A recent advance in generation of a new class of pluripotent stem cells, induced pluripotent stem cells (iPSCs), derived from patients' own skin fibroblasts, opens doors for a totally new field of personalized medicine. Transplantation of NSCs, neurons or glia generated from stem cells in animal models of neurodegenerative diseases, including PD, HD, ALS and AD, demonstrates clinical improvement and also life extension of these animals. Additional therapeutic benefits in these animals can be provided by stem cell-mediated gene transfer of therapeutic genes such as neurotrophic factors and enzymes. Although further research is still needed, cell and gene therapy based on stem cells, particularly using neurons and glia derived from iPSCs, ESCs or NSCs, will become a routine treatment for patients suffering from neurodegenerative diseases and also stroke and spinal cord injury.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Neural stem cell-based treatment for neurodegenerative diseases.

Neural stem cell-based treatment for neurodegenerative diseases.

Source :

English descriptors

Abstract

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