Correlates of Excessive Daytime Sleepiness in De Novo Parkinson's Disease: A Case Control Study
Identifieur interne : 000785 ( Main/Exploration ); précédent : 000784; suivant : 000786Correlates of Excessive Daytime Sleepiness in De Novo Parkinson's Disease: A Case Control Study
Auteurs : Tanya Simuni [États-Unis] ; Chelsea Caspell-Garcia [États-Unis] ; Christopher Coffey [États-Unis] ; Lama M. Chahine [États-Unis] ; Shirley Lasch [États-Unis] ; Wolfgang H. Oertel [Allemagne] ; Geert Mayer ; Birgit Högl [Autriche] ; Ron Postuma [Canada] ; Aleksandar Videnovic [États-Unis] ; Amy Willis Amara [États-Unis] ; Ken Marek [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Disorders of Excessive Somnolence, Parkinson Disease.
- epidemiology : Disorders of Excessive Somnolence, Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Comorbidity, Female, Humans, Male, Middle Aged.
Abstract
This study was undertaken to determine the frequency and correlates of excessive daytime sleepiness in de novo, untreated Parkinson's disease (PD) patients compared with the matched healthy controls.
Data were obtained from the Parkinson's Progression Markers Initiative, an international study of de novo, untreated PD patients and healthy controls. At baseline, participants were assessed with a wide range of motor and nonmotor scales, including the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Excessive daytime sleepiness was assessed based on the Epworth Sleepiness scale (ESS), with a cutoff of 10.
Four hundred twenty-three PD subjects and 196 healthy controls were recruited into the study. Mean ESS (min, max) score was 5.8 (0, 20) for the PD subjects and 5.6 (0, 19) for healthy controls (
This largest case control study demonstrates no difference in prevalence of excessive sleepiness in subjects with de novo untreated PD compared with healthy controls. The only clinical correlates of sleepiness were mood and autonomic dysfunction. Ongoing longitudinal analyses will be essential to further examine clinical and biological correlates of sleepiness in PD and specifically the role of dopaminergic therapy.
Url:
DOI: 10.1002/mds.26248
PubMed: 26095202
PubMed Central: 4822999
Affiliations:
- Allemagne, Autriche, Canada, États-Unis
- District de Darmstadt, Hesse (Land), Iowa, Québec
- Francfort-sur-le-Main, Iowa City, Montréal
- Université McGill, Université de l'Iowa
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Le document en format XML
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
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<imprint><date when="2015">2015</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Comorbidity</term>
<term>Disorders of Excessive Somnolence (diagnosis)</term>
<term>Disorders of Excessive Somnolence (epidemiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (epidemiology)</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Disorders of Excessive Somnolence</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Disorders of Excessive Somnolence</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Comorbidity</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">This study was undertaken to determine the frequency and correlates of excessive daytime sleepiness in de novo, untreated Parkinson's disease (PD) patients compared with the matched healthy controls.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Data were obtained from the Parkinson's Progression Markers Initiative, an international study of de novo, untreated PD patients and healthy controls. At baseline, participants were assessed with a wide range of motor and nonmotor scales, including the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Excessive daytime sleepiness was assessed based on the Epworth Sleepiness scale (ESS), with a cutoff of 10.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Four hundred twenty-three PD subjects and 196 healthy controls were recruited into the study. Mean ESS (min, max) score was 5.8 (0, 20) for the PD subjects and 5.6 (0, 19) for healthy controls (<italic>P</italic>
= 0.54). Sixty-six (15.6%) PD subjects and 24 (12%) healthy controls had ESS of at least 10 (<italic>P</italic>
= 0.28). No difference was seen in demographic characteristics, age of onset, disease duration, PD subtype, cognitive status, or utilization of sedatives between the PD sleepiness-positive versus the negative group. The sleepiness-positive group had higher MDS-UPDRS Part I and II but not III scores, and higher depression and autonomic dysfunction scores. Sleepiness was associated with a marginal reduction of A-beta (<italic>P</italic>
= 0.05) but not alpha-synuclein spinal fluid levels in PD.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">This largest case control study demonstrates no difference in prevalence of excessive sleepiness in subjects with de novo untreated PD compared with healthy controls. The only clinical correlates of sleepiness were mood and autonomic dysfunction. Ongoing longitudinal analyses will be essential to further examine clinical and biological correlates of sleepiness in PD and specifically the role of dopaminergic therapy.</p>
</sec>
</div>
</front>
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<name sortKey="Videnovic, Aleksandar" sort="Videnovic, Aleksandar" uniqKey="Videnovic A" first="Aleksandar" last="Videnovic">Aleksandar Videnovic</name>
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<country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
</region>
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<country name="Autriche"><noRegion><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name>
</noRegion>
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<country name="Canada"><region name="Québec"><name sortKey="Postuma, Ron" sort="Postuma, Ron" uniqKey="Postuma R" first="Ron" last="Postuma">Ron Postuma</name>
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