Hematopoietic cytokines as therapeutic players in early stages Parkinson’s disease
Identifieur interne : 000700 ( Main/Exploration ); précédent : 000699; suivant : 000701Hematopoietic cytokines as therapeutic players in early stages Parkinson’s disease
Auteurs : Kyle Farmer ; Christopher Rudyk ; Natalie A. Prowse ; Shawn HayleySource :
- Frontiers in Aging Neuroscience [ 1663-4365 ] ; 2015.
Abstract
Parkinson’s disease (PD) is a devastating age related neurodegenerative disease that is believed to have a lengthy prodromal state. It is critical to find methods to harness compensatory recovery processes in order to slow or prevent the eventual progression of clinical symptoms. The current perspective paper argues that immune system signaling molecules represent such a promising therapeutic approach. Two cytokines of interest are granulocyte macrophage-colony stimulating factor (GM-CSF) and erythropoietin (EPO). These hematopoietic cytokines have been protective in models of stroke, neuronal injury, and more recently PD. It is our belief that these trophic cytokines can be used not only for cell protection but also regeneration. However, success is likely dependent on early intervention. This paper will outline our perspective on the development of novel trophic recovery treatments for PD. In particular, we present new data from our lab suggesting that EPO and GM-CSF can foster neural re-innervation in a “mild” or partial lesion PD model that could be envisioned as reflecting the early stages of the disease.
Url:
DOI: 10.3389/fnagi.2015.00126
PubMed: 26191001
PubMed Central: 4490238
Affiliations:
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Prowse</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hayley, Shawn" sort="Hayley, Shawn" uniqKey="Hayley S" first="Shawn" last="Hayley">Shawn Hayley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Frontiers in Aging Neuroscience</title><idno type="eISSN">1663-4365</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Parkinson’s disease (PD) is a devastating age related neurodegenerative disease that is believed to have a lengthy prodromal state. It is critical to find methods to harness compensatory recovery processes in order to slow or prevent the eventual progression of clinical symptoms. The current perspective paper argues that immune system signaling molecules represent such a promising therapeutic approach. Two cytokines of interest are granulocyte macrophage-colony stimulating factor (GM-CSF) and erythropoietin (EPO). These hematopoietic cytokines have been protective in models of stroke, neuronal injury, and more recently PD. It is our belief that these trophic cytokines can be used not only for cell protection but also regeneration. However, success is likely dependent on early intervention. This paper will outline our perspective on the development of novel trophic recovery treatments for PD. In particular, we present new data from our lab suggesting that EPO and GM-CSF can foster neural re-innervation in a “mild” or partial lesion PD model that could be envisioned as reflecting the early stages of the disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ai, Y" uniqKey="Ai Y">Y. Ai</name></author><author><name sortKey="Markesbery, W" uniqKey="Markesbery W">W. 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Schäbitz</name></author><author><name sortKey="Kruger, C" uniqKey="Kruger C">C. Krüger</name></author><author><name sortKey="Pitzer, C" uniqKey="Pitzer C">C. Pitzer</name></author><author><name sortKey="Weber, D" uniqKey="Weber D">D. Weber</name></author><author><name sortKey="Laage, R" uniqKey="Laage R">R. Laage</name></author><author><name sortKey="Gassler, N" uniqKey="Gassler N">N. Gassler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sherer, T" uniqKey="Sherer T">T. Sherer</name></author><author><name sortKey="Betarbet, R" uniqKey="Betarbet R">R. Betarbet</name></author><author><name sortKey="Greenamyre, J" uniqKey="Greenamyre J">J. Greenamyre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiele, S L" uniqKey="Thiele S">S. L. Thiele</name></author><author><name sortKey="Warre, R" uniqKey="Warre R">R. Warre</name></author><author><name sortKey="Nash, J E" uniqKey="Nash J">J. E. Nash</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xue, Y Q" uniqKey="Xue Y">Y.-Q. Xue</name></author><author><name sortKey="Zhao, L R" uniqKey="Zhao L">L.-R. Zhao</name></author><author><name sortKey="Guo, W P" uniqKey="Guo W">W.-P. Guo</name></author><author><name sortKey="Duan, W M" uniqKey="Duan W">W.-M. Duan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Farmer, Kyle" sort="Farmer, Kyle" uniqKey="Farmer K" first="Kyle" last="Farmer">Kyle Farmer</name><name sortKey="Hayley, Shawn" sort="Hayley, Shawn" uniqKey="Hayley S" first="Shawn" last="Hayley">Shawn Hayley</name><name sortKey="Prowse, Natalie A" sort="Prowse, Natalie A" uniqKey="Prowse N" first="Natalie A." last="Prowse">Natalie A. 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