Hematopoietic cytokines as therapeutic players in early stages Parkinson’s disease
Identifieur interne : 001C47 ( Ncbi/Merge ); précédent : 001C46; suivant : 001C48Hematopoietic cytokines as therapeutic players in early stages Parkinson’s disease
Auteurs : Kyle Farmer ; Christopher Rudyk ; Natalie A. Prowse ; Shawn HayleySource :
- Frontiers in Aging Neuroscience [ 1663-4365 ] ; 2015.
Abstract
Parkinson’s disease (PD) is a devastating age related neurodegenerative disease that is believed to have a lengthy prodromal state. It is critical to find methods to harness compensatory recovery processes in order to slow or prevent the eventual progression of clinical symptoms. The current perspective paper argues that immune system signaling molecules represent such a promising therapeutic approach. Two cytokines of interest are granulocyte macrophage-colony stimulating factor (GM-CSF) and erythropoietin (EPO). These hematopoietic cytokines have been protective in models of stroke, neuronal injury, and more recently PD. It is our belief that these trophic cytokines can be used not only for cell protection but also regeneration. However, success is likely dependent on early intervention. This paper will outline our perspective on the development of novel trophic recovery treatments for PD. In particular, we present new data from our lab suggesting that EPO and GM-CSF can foster neural re-innervation in a “mild” or partial lesion PD model that could be envisioned as reflecting the early stages of the disease.
Url:
DOI: 10.3389/fnagi.2015.00126
PubMed: 26191001
PubMed Central: 4490238
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Prowse</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hayley, Shawn" sort="Hayley, Shawn" uniqKey="Hayley S" first="Shawn" last="Hayley">Shawn Hayley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Frontiers in Aging Neuroscience</title><idno type="eISSN">1663-4365</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Parkinson’s disease (PD) is a devastating age related neurodegenerative disease that is believed to have a lengthy prodromal state. It is critical to find methods to harness compensatory recovery processes in order to slow or prevent the eventual progression of clinical symptoms. The current perspective paper argues that immune system signaling molecules represent such a promising therapeutic approach. Two cytokines of interest are granulocyte macrophage-colony stimulating factor (GM-CSF) and erythropoietin (EPO). These hematopoietic cytokines have been protective in models of stroke, neuronal injury, and more recently PD. It is our belief that these trophic cytokines can be used not only for cell protection but also regeneration. However, success is likely dependent on early intervention. This paper will outline our perspective on the development of novel trophic recovery treatments for PD. In particular, we present new data from our lab suggesting that EPO and GM-CSF can foster neural re-innervation in a “mild” or partial lesion PD model that could be envisioned as reflecting the early stages of the disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ai, Y" uniqKey="Ai Y">Y. Ai</name></author><author><name sortKey="Markesbery, W" uniqKey="Markesbery W">W. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Aging Neurosci</journal-id><journal-id journal-id-type="iso-abbrev">Front Aging Neurosci</journal-id><journal-id journal-id-type="publisher-id">Front. Aging Neurosci.</journal-id><journal-title-group><journal-title>Frontiers in Aging Neuroscience</journal-title></journal-title-group><issn pub-type="epub">1663-4365</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26191001</article-id><article-id pub-id-type="pmc">4490238</article-id><article-id pub-id-type="doi">10.3389/fnagi.2015.00126</article-id><article-categories><subj-group subj-group-type="heading"><subject>Neuroscience</subject><subj-group><subject>Perspective</subject></subj-group></subj-group></article-categories><title-group><article-title>Hematopoietic cytokines as therapeutic players in early stages Parkinson’s disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Farmer</surname><given-names>Kyle</given-names></name><xref ref-type="aff" rid="aff1"></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/234038"></uri></contrib><contrib contrib-type="author"><name><surname>Rudyk</surname><given-names>Christopher</given-names></name><xref ref-type="aff" rid="aff1"></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/251201"></uri></contrib><contrib contrib-type="author"><name><surname>Prowse</surname><given-names>Natalie A.</given-names></name><xref ref-type="aff" rid="aff1"></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/247338"></uri></contrib><contrib contrib-type="author"><name><surname>Hayley</surname><given-names>Shawn</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/26448"></uri></contrib></contrib-group><aff id="aff1"><institution>Department of Neuroscience, Carleton University</institution><country>Ottawa, ON, Canada</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Fei Yin, University of Southern California, USA</p></fn><fn fn-type="edited-by"><p>Reviewed by: Nicola B. Mercuri, University of Rome Tor Vergata - IRCCS Fondazione Santa Lucia, Italy; Björn Spittau, Albert-Ludwigs-University Freiburg, Germany</p></fn><corresp id="fn001">*Correspondence: Shawn Hayley, Department of Neuroscience, Carleton University, 327 Life Sciences Research Building, 1123 Colonel By Drive, Ottawa, ON K1S5B6, Canada <email xlink:type="simple">shawn_hayley@carleton.ca</email></corresp></author-notes><pub-date pub-type="epub"><day>03</day><month>7</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>7</volume><elocation-id>126</elocation-id><history><date date-type="received"><day>01</day><month>5</month><year>2015</year></date><date date-type="accepted"><day>22</day><month>6</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 Farmer, Rudyk, Prowse and Hayley.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Farmer, Rudyk, Prowse and Hayley</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>Parkinson’s disease (PD) is a devastating age related neurodegenerative disease that is believed to have a lengthy prodromal state. It is critical to find methods to harness compensatory recovery processes in order to slow or prevent the eventual progression of clinical symptoms. The current perspective paper argues that immune system signaling molecules represent such a promising therapeutic approach. Two cytokines of interest are granulocyte macrophage-colony stimulating factor (GM-CSF) and erythropoietin (EPO). These hematopoietic cytokines have been protective in models of stroke, neuronal injury, and more recently PD. It is our belief that these trophic cytokines can be used not only for cell protection but also regeneration. However, success is likely dependent on early intervention. This paper will outline our perspective on the development of novel trophic recovery treatments for PD. In particular, we present new data from our lab suggesting that EPO and GM-CSF can foster neural re-innervation in a “mild” or partial lesion PD model that could be envisioned as reflecting the early stages of the disease.</p></abstract><kwd-group><kwd>Parkinson’s disease</kwd><kwd>early stage</kwd><kwd>cytokines</kwd><kwd>granulocyte macrophage-colony stimulating factor</kwd><kwd>erythropoietin</kwd></kwd-group><counts><fig-count count="2"></fig-count><table-count count="0"></table-count><equation-count count="0"></equation-count><ref-count count="37"></ref-count><page-count count="5"></page-count><word-count count="3110"></word-count></counts></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Farmer, Kyle" sort="Farmer, Kyle" uniqKey="Farmer K" first="Kyle" last="Farmer">Kyle Farmer</name><name sortKey="Hayley, Shawn" sort="Hayley, Shawn" uniqKey="Hayley S" first="Shawn" last="Hayley">Shawn Hayley</name><name sortKey="Prowse, Natalie A" sort="Prowse, Natalie A" uniqKey="Prowse N" first="Natalie A." last="Prowse">Natalie A. Prowse</name><name sortKey="Rudyk, Christopher" sort="Rudyk, Christopher" uniqKey="Rudyk C" first="Christopher" last="Rudyk">Christopher Rudyk</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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