Presenting mitochondrial antigens: PINK1, Parkin and MDVs steal the show.
Identifieur interne : 000230 ( Main/Exploration ); précédent : 000229; suivant : 000231Presenting mitochondrial antigens: PINK1, Parkin and MDVs steal the show.
Auteurs : Rosalind F. Roberts [Canada] ; Edward A. Fon [Canada]Source :
- Cell research [ 1748-7838 ] ; 2016.
Abstract
In a recent paper published in Cell, Matheoud et al. demonstrated that, in response to cellular stress, self-antigens can be extracted from mitochondria via mitochondrial-derived vesicles and presented at the cell surface to trigger an immune response; this pathway, termed mitochondrial antigen presentation (MitAP), is repressed by PINK1 and Parkin. These findings implicate autoimmune mechanisms in Parkinson's disease.
DOI: 10.1038/cr.2016.104
PubMed: 27585536
Affiliations:
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Roberts</name><affiliation wicri:level="4"><nlm:affiliation>McGill Parkinson Program, Neurodegenerative Diseases Group and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, Quebec, H3A 2B4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McGill Parkinson Program, Neurodegenerative Diseases Group and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, Quebec, H3A 2B4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Fon, Edward A" sort="Fon, Edward A" uniqKey="Fon E" first="Edward A" last="Fon">Edward A. Fon</name><affiliation wicri:level="4"><nlm:affiliation>McGill Parkinson Program, Neurodegenerative Diseases Group and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, Quebec, H3A 2B4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McGill Parkinson Program, Neurodegenerative Diseases Group and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, Quebec, H3A 2B4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author></analytic><series><title level="j">Cell research</title><idno type="eISSN">1748-7838</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In a recent paper published in Cell, Matheoud et al. demonstrated that, in response to cellular stress, self-antigens can be extracted from mitochondria via mitochondrial-derived vesicles and presented at the cell surface to trigger an immune response; this pathway, termed mitochondrial antigen presentation (MitAP), is repressed by PINK1 and Parkin. These findings implicate autoimmune mechanisms in Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Roberts, Rosalind F" sort="Roberts, Rosalind F" uniqKey="Roberts R" first="Rosalind F" last="Roberts">Rosalind F. Roberts</name></region><name sortKey="Fon, Edward A" sort="Fon, Edward A" uniqKey="Fon E" first="Edward A" last="Fon">Edward A. Fon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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