Presenting mitochondrial antigens: PINK1, Parkin and MDVs steal the show.
Identifieur interne : 002072 ( Ncbi/Merge ); précédent : 002071; suivant : 002073Presenting mitochondrial antigens: PINK1, Parkin and MDVs steal the show.
Auteurs : Rosalind F. Roberts [Canada] ; Edward A. Fon [Canada]Source :
- Cell research [ 1748-7838 ] ; 2016.
Abstract
In a recent paper published in Cell, Matheoud et al. demonstrated that, in response to cellular stress, self-antigens can be extracted from mitochondria via mitochondrial-derived vesicles and presented at the cell surface to trigger an immune response; this pathway, termed mitochondrial antigen presentation (MitAP), is repressed by PINK1 and Parkin. These findings implicate autoimmune mechanisms in Parkinson's disease.
DOI: 10.1038/cr.2016.104
PubMed: 27585536
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Roberts</name><affiliation wicri:level="4"><nlm:affiliation>McGill Parkinson Program, Neurodegenerative Diseases Group and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, Quebec, H3A 2B4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McGill Parkinson Program, Neurodegenerative Diseases Group and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, Quebec, H3A 2B4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Fon, Edward A" sort="Fon, Edward A" uniqKey="Fon E" first="Edward A" last="Fon">Edward A. Fon</name><affiliation wicri:level="4"><nlm:affiliation>McGill Parkinson Program, Neurodegenerative Diseases Group and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, Quebec, H3A 2B4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McGill Parkinson Program, Neurodegenerative Diseases Group and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, Quebec, H3A 2B4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author></analytic><series><title level="j">Cell research</title><idno type="eISSN">1748-7838</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In a recent paper published in Cell, Matheoud et al. demonstrated that, in response to cellular stress, self-antigens can be extracted from mitochondria via mitochondrial-derived vesicles and presented at the cell surface to trigger an immune response; this pathway, termed mitochondrial antigen presentation (MitAP), is repressed by PINK1 and Parkin. These findings implicate autoimmune mechanisms in Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27585536</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>02</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1748-7838</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>11</Issue><PubDate><Year>2016</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Cell research</Title><ISOAbbreviation>Cell Res.</ISOAbbreviation></Journal><ArticleTitle>Presenting mitochondrial antigens: PINK1, Parkin and MDVs steal the show.</ArticleTitle><Pagination><MedlinePgn>1180-1181</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/cr.2016.104</ELocationID><Abstract><AbstractText>In a recent paper published in Cell, Matheoud et al. demonstrated that, in response to cellular stress, self-antigens can be extracted from mitochondria via mitochondrial-derived vesicles and presented at the cell surface to trigger an immune response; this pathway, termed mitochondrial antigen presentation (MitAP), is repressed by PINK1 and Parkin. These findings implicate autoimmune mechanisms in Parkinson's disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Roberts</LastName><ForeName>Rosalind F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>McGill Parkinson Program, Neurodegenerative Diseases Group and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, Quebec, H3A 2B4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fon</LastName><ForeName>Edward A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>McGill Parkinson Program, Neurodegenerative Diseases Group and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, Quebec, H3A 2B4, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>09</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cell Res</MedlineTA><NlmUniqueID>9425763</NlmUniqueID><ISSNLinking>1001-0602</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Cell Biol. 2016 Aug 1;214(3):275-91</RefSource><PMID Version="1">27458136</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Neurosci. 1988 Nov;43(1-2):1-7</RefSource><PMID Version="1">3215724</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2016 Jul 14;166(2):314-27</RefSource><PMID Version="1">27345367</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>EMBO J. 2014 Feb 18;33(4):282-95</RefSource><PMID Version="1">24446486</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Proteomics. 2013 Sep;12(9):2394-407</RefSource><PMID Version="1">23674617</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 1994 Oct 24;180(2):147-50</RefSource><PMID Version="1">7700568</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 1988 Aug;38(8):1285-91</RefSource><PMID Version="1">3399080</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Biol. 2010 Jan 26;8(1):e1000298</RefSource><PMID Version="1">20126261</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 2015 May 15;29(10 ):989-99</RefSource><PMID Version="1">25995186</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Mol Life Sci. 2011 May;68(9):1533-41</RefSource><PMID Version="1">21390546</PMID></CommentsCorrections></CommentsCorrectionsList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pmc-release"><Year>2017</Year><Month>11</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>9</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27585536</ArticleId><ArticleId IdType="pii">cr2016104</ArticleId><ArticleId IdType="doi">10.1038/cr.2016.104</ArticleId><ArticleId IdType="pmc">PMC5099861</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Roberts, Rosalind F" sort="Roberts, Rosalind F" uniqKey="Roberts R" first="Rosalind F" last="Roberts">Rosalind F. 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