ParkinsonCanadaV1, Main, Curation, bibRecord, 002B32

Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus

Identifieur interne : 002B32 ( Main/Curation ); précédent : 002B31; suivant : 002B33

Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus

Auteurs : Katerina Venderov [Canada] ; Timothy M. Brown [Royaume-Uni] ; Jonathan M. Brotchie [Canada]

Source :

Experimental neurology : (Print) [ 0014-4886 ] ; 2005.

RBID : Pascal:05-0317987

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Cannabinoïde, GABA, Captation, Animal, Rat, Récepteur cannabinoïde CB1, Neurone gabaergique, Glycérol, Noyau gris central.

English descriptors

KwdEn :
- Animal, Basal ganglion, CB1 cannabinoid receptor, Cannabinoid, GABA, Gabaergic neuron, Glycerol, Parkinson disease, Rat, Uptake.

Abstract

In the globus pallidus, cannabinoid CB₁ receptors are localized pre-synaptically on GABAergic neurons. We assessed the influence of the endocannabinoids, anandamide, 2-arachidonoyl-glycerol (2-AG) and noladin ether, on the uptake of [³H]-GABA in pallidal slices from rat. Both 2-AG and noladin ether increased [³H]-GABA uptake (by 40.8 ± 8.0% and 38.4 ± 12.5%). The effect of 2-AG was blocked by the cannabinoid CB₁ receptor antagonist AM 251. In contrast, neither anandamide nor the agonist WIN 55,212-2 had an effect on [³H]-GABA uptake. Different roles might be played by different endocannabinoids, both physiologically and in basal ganglia disorders, such as Parkinson's disease.

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Le document en format XML

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<author><name sortKey="Brotchie, Jonathan M" sort="Brotchie, Jonathan M" uniqKey="Brotchie J" first="Jonathan M." last="Brotchie">Jonathan M. Brotchie</name>
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<author><name sortKey="Brotchie, Jonathan M" sort="Brotchie, Jonathan M" uniqKey="Brotchie J" first="Jonathan M." last="Brotchie">Jonathan M. Brotchie</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Basal ganglion</term>
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<term>Cannabinoid</term>
<term>GABA</term>
<term>Gabaergic neuron</term>
<term>Glycerol</term>
<term>Parkinson disease</term>
<term>Rat</term>
<term>Uptake</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Cannabinoïde</term>
<term>GABA</term>
<term>Captation</term>
<term>Animal</term>
<term>Rat</term>
<term>Récepteur cannabinoïde CB1</term>
<term>Neurone gabaergique</term>
<term>Glycérol</term>
<term>Noyau gris central</term>
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<front><div type="abstract" xml:lang="en">In the globus pallidus, cannabinoid CB<sub>1</sub>
 receptors are localized pre-synaptically on GABAergic neurons. We assessed the influence of the endocannabinoids, anandamide, 2-arachidonoyl-glycerol (2-AG) and noladin ether, on the uptake of [<sup>3</sup>
H]-GABA in pallidal slices from rat. Both 2-AG and noladin ether increased [<sup>3</sup>
H]-GABA uptake (by 40.8 ± 8.0% and 38.4 ± 12.5%). The effect of 2-AG was blocked by the cannabinoid CB<sub>1</sub>
 receptor antagonist AM 251. In contrast, neither anandamide nor the agonist WIN 55,212-2 had an effect on [<sup>3</sup>
H]-GABA uptake. Different roles might be played by different endocannabinoids, both physiologically and in basal ganglia disorders, such as Parkinson's disease.</div>
</front>
</TEI>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
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Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus

Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri