Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus
Identifieur interne : 002E71 ( Main/Merge ); précédent : 002E70; suivant : 002E72Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus
Auteurs : Katerina Venderov [Canada] ; Timothy M. Brown [Royaume-Uni] ; Jonathan M. Brotchie [Canada]Source :
- Experimental neurology : (Print) [ 0014-4886 ] ; 2005.
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- Pascal (Inist)
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- KwdEn :
Abstract
In the globus pallidus, cannabinoid CB1 receptors are localized pre-synaptically on GABAergic neurons. We assessed the influence of the endocannabinoids, anandamide, 2-arachidonoyl-glycerol (2-AG) and noladin ether, on the uptake of [3H]-GABA in pallidal slices from rat. Both 2-AG and noladin ether increased [3H]-GABA uptake (by 40.8 ± 8.0% and 38.4 ± 12.5%). The effect of 2-AG was blocked by the cannabinoid CB1 receptor antagonist AM 251. In contrast, neither anandamide nor the agonist WIN 55,212-2 had an effect on [3H]-GABA uptake. Different roles might be played by different endocannabinoids, both physiologically and in basal ganglia disorders, such as Parkinson's disease.
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Pascal:05-0317987Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
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<term>CB1 cannabinoid receptor</term>
<term>Cannabinoid</term>
<term>GABA</term>
<term>Gabaergic neuron</term>
<term>Glycerol</term>
<term>Parkinson disease</term>
<term>Rat</term>
<term>Uptake</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Cannabinoïde</term>
<term>GABA</term>
<term>Captation</term>
<term>Animal</term>
<term>Rat</term>
<term>Récepteur cannabinoïde CB1</term>
<term>Neurone gabaergique</term>
<term>Glycérol</term>
<term>Noyau gris central</term>
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<front><div type="abstract" xml:lang="en">In the globus pallidus, cannabinoid CB<sub>1</sub>
receptors are localized pre-synaptically on GABAergic neurons. We assessed the influence of the endocannabinoids, anandamide, 2-arachidonoyl-glycerol (2-AG) and noladin ether, on the uptake of [<sup>3</sup>
H]-GABA in pallidal slices from rat. Both 2-AG and noladin ether increased [<sup>3</sup>
H]-GABA uptake (by 40.8 ± 8.0% and 38.4 ± 12.5%). The effect of 2-AG was blocked by the cannabinoid CB<sub>1</sub>
receptor antagonist AM 251. In contrast, neither anandamide nor the agonist WIN 55,212-2 had an effect on [<sup>3</sup>
H]-GABA uptake. Different roles might be played by different endocannabinoids, both physiologically and in basal ganglia disorders, such as Parkinson's disease.</div>
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