ParkinsonCanadaV1, Main, Curation, bibRecord, 001420

Head injury, alpha‐synuclein Rep1, and Parkinson's disease

Identifieur interne : 001420 ( Main/Curation ); précédent : 001419; suivant : 001421

Head injury, alpha‐synuclein Rep1, and Parkinson's disease

Auteurs : Samuel M. Goldman [États-Unis] ; Freya Kamel [États-Unis] ; G. Webster Ross [États-Unis] ; Sarah A. Jewell [États-Unis, Allemagne] ; Grace S. Bhudhikanok [États-Unis] ; David Umbach [États-Unis] ; Connie Marras [Canada] ; Robert A. Hauser [États-Unis] ; Joseph Jankovic [États-Unis] ; Stewart A. Factor [États-Unis] ; Susan Bressman [États-Unis] ; Kelly E. Lyons [États-Unis] ; Cheryl Meng [États-Unis] ; Monica Korell [États-Unis] ; Diana F. Roucoux [États-Unis] ; Jane A. Hoppin [États-Unis] ; Dale P. Sandler [États-Unis] ; J. William Langston [États-Unis] ; Caroline M. Tanner [États-Unis]

Source :

Annals of Neurology [ 0364-5134 ] ; 2012-01.

RBID : ISTEX:82D3B460AC260AB59F51A718A071AC13DC5DAD6C

Descripteurs français

Pascal (Inist)
- Crânioencéphalique, Maladie de Parkinson, Pathologie du système nerveux, Traumatisme crânien.

English descriptors

KwdEn :
- Craniocerebral, Head trauma, Nervous system diseases, Parkinson disease.

Abstract

To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α‐synuclein, modifies the association between head injury and Parkinson's disease (PD) risk.

Url:

DOI: 10.1002/ana.22499

Links toward previous steps (curation, corpus...)

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to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :001572

Links to Exploration step

ISTEX:82D3B460AC260AB59F51A718A071AC13DC5DAD6C

Le document en format XML

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<front><div type="abstract">To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α‐synuclein, modifies the association between head injury and Parkinson's disease (PD) risk.</div>
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<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Umbach, David" sort="Umbach, David" uniqKey="Umbach D" first="David" last="Umbach">David Umbach</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, DHHS</s1>
<s2>Research Triangle Park, NC;</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Research Triangle Park, NC;</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Neurology, Toronto Western Hospital, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Neurology, University of South Florida</s1>
<s2>Tampa, FL</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Tampa</settlement>
<region type="state">Floride</region>
</placeName>
<orgName type="university">Université de Floride du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, TX</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
<orgName type="university">Baylor College of Medicine</orgName>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
<orgName type="university" n="3">Baylor College of Medicine</orgName>
</affiliation>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A." last="Factor">Stewart A. Factor</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, Emory University School of Medicine</s1>
<s2>Atlanta, GA;</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Atlanta, GA;</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Neurology, Beth Israel Medical Center</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>New York, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly E." last="Lyons">Kelly E. Lyons</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, University of Kansas Medical Center</s1>
<s2>Kansas City, KS</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Kansas City, KS</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meng, Cheryl" sort="Meng, Cheryl" uniqKey="Meng C" first="Cheryl" last="Meng">Cheryl Meng</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Korell, Monica" sort="Korell, Monica" uniqKey="Korell M" first="Monica" last="Korell">Monica Korell</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roucoux, Diana F" sort="Roucoux, Diana F" uniqKey="Roucoux D" first="Diana F." last="Roucoux">Diana F. Roucoux</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hoppin, Jane A" sort="Hoppin, Jane A" uniqKey="Hoppin J" first="Jane A." last="Hoppin">Jane A. Hoppin</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Epidemiology Branch</s1>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Epidemiology Branch</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sandler, Dale P" sort="Sandler, Dale P" uniqKey="Sandler D" first="Dale P." last="Sandler">Dale P. Sandler</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Epidemiology Branch</s1>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Epidemiology Branch</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="William Langston, J" sort="William Langston, J" uniqKey="William Langston J" first="J." last="William Langston">J. William Langston</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0075975</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0075975 INIST</idno>
<idno type="RBID">Pascal:12-0075975</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000232</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000A20</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000158</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000158</idno>
<idno type="wicri:doubleKey">0364-5134:2012:Goldman S:head:injury:alpha</idno>
<idno type="wicri:Area/Main/Merge">001572</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Head Injury, Alpha-Synuclein Rep1, and Parkinson's Disease</title>
<author><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M." last="Goldman">Samuel M. Goldman</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kamel, Freya" sort="Kamel, Freya" uniqKey="Kamel F" first="Freya" last="Kamel">Freya Kamel</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Epidemiology Branch</s1>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Epidemiology Branch</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Webster Ross, G" sort="Webster Ross, G" uniqKey="Webster Ross G" first="G." last="Webster Ross">G. Webster Ross</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Veterans Affairs Pacific Islands Health Care System</s1>
<s2>Honolulu, HI</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Veterans Affairs Pacific Islands Health Care System</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jewell, Sarah A" sort="Jewell, Sarah A" uniqKey="Jewell S" first="Sarah A." last="Jewell">Sarah A. Jewell</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>DZNE, German Center for Neurodegenerative Diseases</s1>
<s2>Bonn</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhudhikanok, Grace S" sort="Bhudhikanok, Grace S" uniqKey="Bhudhikanok G" first="Grace S." last="Bhudhikanok">Grace S. Bhudhikanok</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Umbach, David" sort="Umbach, David" uniqKey="Umbach D" first="David" last="Umbach">David Umbach</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, DHHS</s1>
<s2>Research Triangle Park, NC;</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Research Triangle Park, NC;</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Neurology, Toronto Western Hospital, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Neurology, University of South Florida</s1>
<s2>Tampa, FL</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Tampa</settlement>
<region type="state">Floride</region>
</placeName>
<orgName type="university">Université de Floride du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, TX</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
<orgName type="university">Baylor College of Medicine</orgName>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
<orgName type="university" n="3">Baylor College of Medicine</orgName>
</affiliation>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A." last="Factor">Stewart A. Factor</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, Emory University School of Medicine</s1>
<s2>Atlanta, GA;</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Atlanta, GA;</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Neurology, Beth Israel Medical Center</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>New York, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly E." last="Lyons">Kelly E. Lyons</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, University of Kansas Medical Center</s1>
<s2>Kansas City, KS</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Kansas City, KS</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meng, Cheryl" sort="Meng, Cheryl" uniqKey="Meng C" first="Cheryl" last="Meng">Cheryl Meng</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Korell, Monica" sort="Korell, Monica" uniqKey="Korell M" first="Monica" last="Korell">Monica Korell</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roucoux, Diana F" sort="Roucoux, Diana F" uniqKey="Roucoux D" first="Diana F." last="Roucoux">Diana F. Roucoux</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hoppin, Jane A" sort="Hoppin, Jane A" uniqKey="Hoppin J" first="Jane A." last="Hoppin">Jane A. Hoppin</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Epidemiology Branch</s1>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Epidemiology Branch</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sandler, Dale P" sort="Sandler, Dale P" uniqKey="Sandler D" first="Dale P." last="Sandler">Dale P. Sandler</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Epidemiology Branch</s1>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Epidemiology Branch</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="William Langston, J" sort="William Langston, J" uniqKey="William Langston J" first="J." last="William Langston">J. William Langston</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Parkinson's Institute</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
<imprint><date when="2012">2012</date>
</imprint>
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<seriesStmt><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Craniocerebral</term>
<term>Head trauma</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Traumatisme crânien</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Crânioencéphalique</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Objective: To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α-synuclein, modifies the association between head injury and Parkinson's disease (PD) risk. Methods: Participants in the Farming and Movement Evaluation (FAME) and the Study of Environmental Association and Risk of Parkinsonism using Case-Control Historical Interviews (SEARCH), 2 independent case-control studies, were genotyped for Rep1 and interviewed regarding head injuries with loss of consciousness or concussion prior to Parkinson's disease (PD) diagnosis. Logistic regression modeling adjusted for potential confounding variables and tested interaction between Rep1 genotype and head injury. Results: Consistent with prior reports, relative to medium-length Rep1, short Rep1 genotype was associated with reduced PD risk (pooled odds ratio [OR], 0.7; 95% confidence interval [CI], 0.5-0.9), and long Rep1 with increased risk (pooled OR, 1.4; 95% CI, 0.95-2.2). Overall, head injury was not significantly associated with PD (pooled OR, 1.3; 95% CI, 0.9-1.8). However, head injury was strongly associated with PD in those with long Rep1 (FAME OR, 5.4; 95% CI, 1.5-19; SEARCH OR, 2.3; 95% CI, 0.6-9.2; pooled OR, 3.5; 95% CI 1.4-9.2, p-interaction = 0.02). Individuals with both head injury and long Rep1 were diagnosed 4.9 years earlier than those with neither risk factor (p = 0.03). Interpretation: While head injury alone was not associated with PD risk, our data suggest head injury may initiate and/or accelerate neurodegeneration when levels of synuclein are high, as in those with Rep1 expansion. Given the high population frequency of head injury, independent verification of these results is essential.</div>
</front>
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<author><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M." last="Goldman">Samuel M. Goldman</name>
</author>
<author><name sortKey="Kamel, Freya" sort="Kamel, Freya" uniqKey="Kamel F" first="Freya" last="Kamel">Freya Kamel</name>
</author>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
</author>
<author><name sortKey="Jewell, Sarah A" sort="Jewell, Sarah A" uniqKey="Jewell S" first="Sarah A." last="Jewell">Sarah A. Jewell</name>
</author>
<author><name sortKey="Bhudhikanok, Grace S" sort="Bhudhikanok, Grace S" uniqKey="Bhudhikanok G" first="Grace S." last="Bhudhikanok">Grace S. Bhudhikanok</name>
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<author><name sortKey="Umbach, David" sort="Umbach, David" uniqKey="Umbach D" first="David" last="Umbach">David Umbach</name>
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</author>
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</author>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation><country>États-Unis</country>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
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<orgName type="university" n="3">Baylor College of Medicine</orgName>
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<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A." last="Factor">Stewart A. Factor</name>
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<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Head injury, alpha‐synuclein Rep1, and Parkinson's disease</title>
<author><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M." last="Goldman">Samuel M. Goldman</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson's Institute, Sunnyvale</wicri:cityArea>
</affiliation>
<affiliation></affiliation>
</author>
<author><name sortKey="Kamel, Freya" sort="Kamel, Freya" uniqKey="Kamel F" first="Freya" last="Kamel">Freya Kamel</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Veterans Affairs Pacific Islands Health Care System, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jewell, Sarah A" sort="Jewell, Sarah A" uniqKey="Jewell S" first="Sarah A." last="Jewell">Sarah A. Jewell</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson's Institute, Sunnyvale</wicri:cityArea>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>DZNE, German Center for Neurodegenerative Diseases, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhudhikanok, Grace S" sort="Bhudhikanok, Grace S" uniqKey="Bhudhikanok G" first="Grace S." last="Bhudhikanok">Grace S. Bhudhikanok</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson's Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Umbach, David" sort="Umbach, David" uniqKey="Umbach D" first="David" last="Umbach">David Umbach</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of South Florida, Tampa</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Neurology, Baylor College of Medicine, Houston</wicri:cityArea>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
<orgName type="university" n="3">Baylor College of Medicine</orgName>
</affiliation>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A." last="Factor">Stewart A. Factor</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Department of Neurology, Emory University School of Medicine, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Neurology, Beth Israel Medical Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly E." last="Lyons">Kelly E. Lyons</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Kansas Medical Center, Kansas City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Meng, Cheryl" sort="Meng, Cheryl" uniqKey="Meng C" first="Cheryl" last="Meng">Cheryl Meng</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson's Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Korell, Monica" sort="Korell, Monica" uniqKey="Korell M" first="Monica" last="Korell">Monica Korell</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson's Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Roucoux, Diana F" sort="Roucoux, Diana F" uniqKey="Roucoux D" first="Diana F." last="Roucoux">Diana F. Roucoux</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson's Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hoppin, Jane A" sort="Hoppin, Jane A" uniqKey="Hoppin J" first="Jane A." last="Hoppin">Jane A. Hoppin</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sandler, Dale P" sort="Sandler, Dale P" uniqKey="Sandler D" first="Dale P." last="Sandler">Dale P. Sandler</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Langston, J William" sort="Langston, J William" uniqKey="Langston J" first="J. William" last="Langston">J. William Langston</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson's Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson's Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Annals of Neurology</title>
<title level="j" type="abbrev">Ann Neurol.</title>
<idno type="ISSN">0364-5134</idno>
<idno type="eISSN">1531-8249</idno>
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<pubPlace>Hoboken</pubPlace>
<date type="published" when="2012-01">2012-01</date>
<biblScope unit="volume">71</biblScope>
<biblScope unit="issue">1</biblScope>
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<front><div type="abstract">To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α‐synuclein, modifies the association between head injury and Parkinson's disease (PD) risk.</div>
</front>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Head injury, alpha‐synuclein Rep1, and Parkinson's disease

Head injury, alpha‐synuclein Rep1, and Parkinson's disease

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