ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000232

Head Injury, Alpha-Synuclein Rep1, and Parkinson's Disease

Identifieur interne : 000232 ( PascalFrancis/Corpus ); précédent : 000231; suivant : 000233

Head Injury, Alpha-Synuclein Rep1, and Parkinson's Disease

Auteurs : Samuel M. Goldman ; Freya Kamel ; G. Webster Ross ; Sarah A. Jewell ; Grace S. Bhudhikanok ; David Umbach ; Connie Marras ; Robert A. Hauser ; Joseph Jankovic ; Stewart A. Factor ; Susan Bressman ; Kelly E. Lyons ; Cheryl Meng ; Monica Korell ; Diana F. Roucoux ; Jane A. Hoppin ; Dale P. Sandler ; J. William Langston ; Caroline M. Tanner

Source :

Annals of neurology [ 0364-5134 ] ; 2012.

RBID : Pascal:12-0075975

Descripteurs français

Pascal (Inist)
- Traumatisme crânien, Maladie de Parkinson, Pathologie du système nerveux, Crânioencéphalique.

English descriptors

KwdEn :
- Craniocerebral, Head trauma, Nervous system diseases, Parkinson disease.

Abstract

Objective: To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α-synuclein, modifies the association between head injury and Parkinson's disease (PD) risk. Methods: Participants in the Farming and Movement Evaluation (FAME) and the Study of Environmental Association and Risk of Parkinsonism using Case-Control Historical Interviews (SEARCH), 2 independent case-control studies, were genotyped for Rep1 and interviewed regarding head injuries with loss of consciousness or concussion prior to Parkinson's disease (PD) diagnosis. Logistic regression modeling adjusted for potential confounding variables and tested interaction between Rep1 genotype and head injury. Results: Consistent with prior reports, relative to medium-length Rep1, short Rep1 genotype was associated with reduced PD risk (pooled odds ratio [OR], 0.7; 95% confidence interval [CI], 0.5-0.9), and long Rep1 with increased risk (pooled OR, 1.4; 95% CI, 0.95-2.2). Overall, head injury was not significantly associated with PD (pooled OR, 1.3; 95% CI, 0.9-1.8). However, head injury was strongly associated with PD in those with long Rep1 (FAME OR, 5.4; 95% CI, 1.5-19; SEARCH OR, 2.3; 95% CI, 0.6-9.2; pooled OR, 3.5; 95% CI 1.4-9.2, p-interaction = 0.02). Individuals with both head injury and long Rep1 were diagnosed 4.9 years earlier than those with neither risk factor (p = 0.03). Interpretation: While head injury alone was not associated with PD risk, our data suggest head injury may initiate and/or accelerate neurodegeneration when levels of synuclein are high, as in those with Rep1 expansion. Given the high population frequency of head injury, independent verification of these results is essential.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0364-5134`
A02	`01`			`@0 ANNED3`
A03		`1`		`@0 Ann. neurol.`
A05				`@2 71`
A06				`@2 1`
A08	`01`	`1`	`ENG`	`@1 Head Injury, Alpha-Synuclein Rep1, and Parkinson's Disease`
A11	`01`	`1`		`@1 GOLDMAN (Samuel M.)`
A11	`02`	`1`		`@1 KAMEL (Freya)`
A11	`03`	`1`		`@1 WEBSTER ROSS (G.)`
A11	`04`	`1`		`@1 JEWELL (Sarah A.)`
A11	`05`	`1`		`@1 BHUDHIKANOK (Grace S.)`
A11	`06`	`1`		`@1 UMBACH (David)`
A11	`07`	`1`		`@1 MARRAS (Connie)`
A11	`08`	`1`		`@1 HAUSER (Robert A.)`
A11	`09`	`1`		`@1 JANKOVIC (Joseph)`
A11	`10`	`1`		`@1 FACTOR (Stewart A.)`
A11	`11`	`1`		`@1 BRESSMAN (Susan)`
A11	`12`	`1`		`@1 LYONS (Kelly E.)`
A11	`13`	`1`		`@1 MENG (Cheryl)`
A11	`14`	`1`		`@1 KORELL (Monica)`
A11	`15`	`1`		`@1 ROUCOUX (Diana F.)`
A11	`16`	`1`		`@1 HOPPIN (Jane A.)`
A11	`17`	`1`		`@1 SANDLER (Dale P.)`
A11	`18`	`1`		`@1 WILLIAM LANGSTON (J.)`
A11	`19`	`1`		`@1 TANNER (Caroline M.)`
A14	`01`			`@1 The Parkinson's Institute @2 Sunnyvale, CA @3 USA @Z 1 aut. @Z 4 aut. @Z 5 aut. @Z 13 aut. @Z 14 aut. @Z 15 aut. @Z 18 aut. @Z 19 aut.`
A14	`02`			`@1 Epidemiology Branch @3 USA @Z 2 aut. @Z 16 aut. @Z 17 aut.`
A14	`03`			`@1 Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, DHHS @2 Research Triangle Park, NC; @3 USA @Z 6 aut.`
A14	`04`			`@1 Veterans Affairs Pacific Islands Health Care System @2 Honolulu, HI @3 USA @Z 3 aut.`
A14	`05`			`@1 DZNE, German Center for Neurodegenerative Diseases @2 Bonn @3 DEU @Z 4 aut.`
A14	`06`			`@1 Neurology, Toronto Western Hospital, University of Toronto @2 Toronto, Ontario @3 CAN @Z 7 aut.`
A14	`07`			`@1 Department of Neurology, University of South Florida @2 Tampa, FL @3 USA @Z 8 aut.`
A14	`08`			`@1 Department of Neurology, Baylor College of Medicine @2 Houston, TX @3 USA @Z 9 aut.`
A14	`09`			`@1 Department of Neurology, Emory University School of Medicine @2 Atlanta, GA; @3 USA @Z 10 aut.`
A14	`10`			`@1 Department of Neurology, Beth Israel Medical Center @2 New York, NY @3 USA @Z 11 aut.`
A14	`11`			`@1 Department of Neurology, University of Kansas Medical Center @2 Kansas City, KS @3 USA @Z 12 aut.`
A20				`@1 40-48`
A21				`@1 2012`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 16555 @5 354000508658160070`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
A45				`@0 68 ref.`
A47	`01`	`1`		`@0 12-0075975`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Annals of neurology`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Objective: To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α-synuclein, modifies the association between head injury and Parkinson's disease (PD) risk. Methods: Participants in the Farming and Movement Evaluation (FAME) and the Study of Environmental Association and Risk of Parkinsonism using Case-Control Historical Interviews (SEARCH), 2 independent case-control studies, were genotyped for Rep1 and interviewed regarding head injuries with loss of consciousness or concussion prior to Parkinson's disease (PD) diagnosis. Logistic regression modeling adjusted for potential confounding variables and tested interaction between Rep1 genotype and head injury. Results: Consistent with prior reports, relative to medium-length Rep1, short Rep1 genotype was associated with reduced PD risk (pooled odds ratio [OR], 0.7; 95% confidence interval [CI], 0.5-0.9), and long Rep1 with increased risk (pooled OR, 1.4; 95% CI, 0.95-2.2). Overall, head injury was not significantly associated with PD (pooled OR, 1.3; 95% CI, 0.9-1.8). However, head injury was strongly associated with PD in those with long Rep1 (FAME OR, 5.4; 95% CI, 1.5-19; SEARCH OR, 2.3; 95% CI, 0.6-9.2; pooled OR, 3.5; 95% CI 1.4-9.2, p-interaction = 0.02). Individuals with both head injury and long Rep1 were diagnosed 4.9 years earlier than those with neither risk factor (p = 0.03). Interpretation: While head injury alone was not associated with PD risk, our data suggest head injury may initiate and/or accelerate neurodegeneration when levels of synuclein are high, as in those with Rep1 expansion. Given the high population frequency of head injury, independent verification of these results is essential.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Traumatisme crânien @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Head trauma @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Traumatismo craneoencefálico @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 02`
C03	`02`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 02`
C03	`02`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 02`
C03	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 03`
C03	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 03`
C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Crânioencéphalique @5 09`
C03	`04`	`X`	`ENG`	`@0 Craniocerebral @5 09`
C03	`04`	`X`	`SPA`	`@0 Craneoencefálico @5 09`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 38`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 38`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 38`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 39`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 39`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 39`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 40`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 40`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 40`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 41`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 41`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 41`
N21				`@1 058`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 12-0075975 INIST
ET :	Head Injury, Alpha-Synuclein Rep1, and Parkinson's Disease
AU :	GOLDMAN (Samuel M.); KAMEL (Freya); WEBSTER ROSS (G.); JEWELL (Sarah A.); BHUDHIKANOK (Grace S.); UMBACH (David); MARRAS (Connie); HAUSER (Robert A.); JANKOVIC (Joseph); FACTOR (Stewart A.); BRESSMAN (Susan); LYONS (Kelly E.); MENG (Cheryl); KORELL (Monica); ROUCOUX (Diana F.); HOPPIN (Jane A.); SANDLER (Dale P.); WILLIAM LANGSTON (J.); TANNER (Caroline M.)
AF :	The Parkinson's Institute/Sunnyvale, CA/Etats-Unis (1 aut., 4 aut., 5 aut., 13 aut., 14 aut., 15 aut., 18 aut., 19 aut.); Epidemiology Branch/Etats-Unis (2 aut., 16 aut., 17 aut.); Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, DHHS/Research Triangle Park, NC;/Etats-Unis (6 aut.); Veterans Affairs Pacific Islands Health Care System/Honolulu, HI/Etats-Unis (3 aut.); DZNE, German Center for Neurodegenerative Diseases/Bonn/Allemagne (4 aut.); Neurology, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (7 aut.); Department of Neurology, University of South Florida/Tampa, FL/Etats-Unis (8 aut.); Department of Neurology, Baylor College of Medicine/Houston, TX/Etats-Unis (9 aut.); Department of Neurology, Emory University School of Medicine/Atlanta, GA;/Etats-Unis (10 aut.); Department of Neurology, Beth Israel Medical Center/New York, NY/Etats-Unis (11 aut.); Department of Neurology, University of Kansas Medical Center/Kansas City, KS/Etats-Unis (12 aut.)
DT :	Publication en série; Niveau analytique
SO :	Annals of neurology; ISSN 0364-5134; Coden ANNED3; Etats-Unis; Da. 2012; Vol. 71; No. 1; Pp. 40-48; Bibl. 68 ref.
LA :	Anglais
EA :	Objective: To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α-synuclein, modifies the association between head injury and Parkinson's disease (PD) risk. Methods: Participants in the Farming and Movement Evaluation (FAME) and the Study of Environmental Association and Risk of Parkinsonism using Case-Control Historical Interviews (SEARCH), 2 independent case-control studies, were genotyped for Rep1 and interviewed regarding head injuries with loss of consciousness or concussion prior to Parkinson's disease (PD) diagnosis. Logistic regression modeling adjusted for potential confounding variables and tested interaction between Rep1 genotype and head injury. Results: Consistent with prior reports, relative to medium-length Rep1, short Rep1 genotype was associated with reduced PD risk (pooled odds ratio [OR], 0.7; 95% confidence interval [CI], 0.5-0.9), and long Rep1 with increased risk (pooled OR, 1.4; 95% CI, 0.95-2.2). Overall, head injury was not significantly associated with PD (pooled OR, 1.3; 95% CI, 0.9-1.8). However, head injury was strongly associated with PD in those with long Rep1 (FAME OR, 5.4; 95% CI, 1.5-19; SEARCH OR, 2.3; 95% CI, 0.6-9.2; pooled OR, 3.5; 95% CI 1.4-9.2, p-interaction = 0.02). Individuals with both head injury and long Rep1 were diagnosed 4.9 years earlier than those with neither risk factor (p = 0.03). Interpretation: While head injury alone was not associated with PD risk, our data suggest head injury may initiate and/or accelerate neurodegeneration when levels of synuclein are high, as in those with Rep1 expansion. Given the high population frequency of head injury, independent verification of these results is essential.
CC :	002B17; 002B17G
FD :	Traumatisme crânien; Maladie de Parkinson; Pathologie du système nerveux; Crânioencéphalique
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Head trauma; Parkinson disease; Nervous system diseases; Craniocerebral
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Traumatismo craneoencefálico; Parkinson enfermedad; Sistema nervioso patología; Craneoencefálico
LO :	INIST-16555.354000508658160070
ID :	12-0075975

Links to Exploration step

Pascal:12-0075975

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Head Injury, Alpha-Synuclein Rep1, and Parkinson's Disease</title>
<author><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M." last="Goldman">Samuel M. Goldman</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kamel, Freya" sort="Kamel, Freya" uniqKey="Kamel F" first="Freya" last="Kamel">Freya Kamel</name>
<affiliation><inist:fA14 i1="02"><s1>Epidemiology Branch</s1>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Webster Ross, G" sort="Webster Ross, G" uniqKey="Webster Ross G" first="G." last="Webster Ross">G. Webster Ross</name>
<affiliation><inist:fA14 i1="04"><s1>Veterans Affairs Pacific Islands Health Care System</s1>
<s2>Honolulu, HI</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jewell, Sarah A" sort="Jewell, Sarah A" uniqKey="Jewell S" first="Sarah A." last="Jewell">Sarah A. Jewell</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="05"><s1>DZNE, German Center for Neurodegenerative Diseases</s1>
<s2>Bonn</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bhudhikanok, Grace S" sort="Bhudhikanok, Grace S" uniqKey="Bhudhikanok G" first="Grace S." last="Bhudhikanok">Grace S. Bhudhikanok</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Umbach, David" sort="Umbach, David" uniqKey="Umbach D" first="David" last="Umbach">David Umbach</name>
<affiliation><inist:fA14 i1="03"><s1>Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, DHHS</s1>
<s2>Research Triangle Park, NC;</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
<affiliation><inist:fA14 i1="06"><s1>Neurology, Toronto Western Hospital, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Neurology, University of South Florida</s1>
<s2>Tampa, FL</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation><inist:fA14 i1="08"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, TX</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A." last="Factor">Stewart A. Factor</name>
<affiliation><inist:fA14 i1="09"><s1>Department of Neurology, Emory University School of Medicine</s1>
<s2>Atlanta, GA;</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name>
<affiliation><inist:fA14 i1="10"><s1>Department of Neurology, Beth Israel Medical Center</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly E." last="Lyons">Kelly E. Lyons</name>
<affiliation><inist:fA14 i1="11"><s1>Department of Neurology, University of Kansas Medical Center</s1>
<s2>Kansas City, KS</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Meng, Cheryl" sort="Meng, Cheryl" uniqKey="Meng C" first="Cheryl" last="Meng">Cheryl Meng</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Korell, Monica" sort="Korell, Monica" uniqKey="Korell M" first="Monica" last="Korell">Monica Korell</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Roucoux, Diana F" sort="Roucoux, Diana F" uniqKey="Roucoux D" first="Diana F." last="Roucoux">Diana F. Roucoux</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hoppin, Jane A" sort="Hoppin, Jane A" uniqKey="Hoppin J" first="Jane A." last="Hoppin">Jane A. Hoppin</name>
<affiliation><inist:fA14 i1="02"><s1>Epidemiology Branch</s1>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Sandler, Dale P" sort="Sandler, Dale P" uniqKey="Sandler D" first="Dale P." last="Sandler">Dale P. Sandler</name>
<affiliation><inist:fA14 i1="02"><s1>Epidemiology Branch</s1>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="William Langston, J" sort="William Langston, J" uniqKey="William Langston J" first="J." last="William Langston">J. William Langston</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0075975</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0075975 INIST</idno>
<idno type="RBID">Pascal:12-0075975</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000232</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Head Injury, Alpha-Synuclein Rep1, and Parkinson's Disease</title>
<author><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M." last="Goldman">Samuel M. Goldman</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kamel, Freya" sort="Kamel, Freya" uniqKey="Kamel F" first="Freya" last="Kamel">Freya Kamel</name>
<affiliation><inist:fA14 i1="02"><s1>Epidemiology Branch</s1>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Webster Ross, G" sort="Webster Ross, G" uniqKey="Webster Ross G" first="G." last="Webster Ross">G. Webster Ross</name>
<affiliation><inist:fA14 i1="04"><s1>Veterans Affairs Pacific Islands Health Care System</s1>
<s2>Honolulu, HI</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jewell, Sarah A" sort="Jewell, Sarah A" uniqKey="Jewell S" first="Sarah A." last="Jewell">Sarah A. Jewell</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="05"><s1>DZNE, German Center for Neurodegenerative Diseases</s1>
<s2>Bonn</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bhudhikanok, Grace S" sort="Bhudhikanok, Grace S" uniqKey="Bhudhikanok G" first="Grace S." last="Bhudhikanok">Grace S. Bhudhikanok</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Umbach, David" sort="Umbach, David" uniqKey="Umbach D" first="David" last="Umbach">David Umbach</name>
<affiliation><inist:fA14 i1="03"><s1>Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, DHHS</s1>
<s2>Research Triangle Park, NC;</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
<affiliation><inist:fA14 i1="06"><s1>Neurology, Toronto Western Hospital, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Neurology, University of South Florida</s1>
<s2>Tampa, FL</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation><inist:fA14 i1="08"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, TX</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A." last="Factor">Stewart A. Factor</name>
<affiliation><inist:fA14 i1="09"><s1>Department of Neurology, Emory University School of Medicine</s1>
<s2>Atlanta, GA;</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name>
<affiliation><inist:fA14 i1="10"><s1>Department of Neurology, Beth Israel Medical Center</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly E." last="Lyons">Kelly E. Lyons</name>
<affiliation><inist:fA14 i1="11"><s1>Department of Neurology, University of Kansas Medical Center</s1>
<s2>Kansas City, KS</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Meng, Cheryl" sort="Meng, Cheryl" uniqKey="Meng C" first="Cheryl" last="Meng">Cheryl Meng</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Korell, Monica" sort="Korell, Monica" uniqKey="Korell M" first="Monica" last="Korell">Monica Korell</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Roucoux, Diana F" sort="Roucoux, Diana F" uniqKey="Roucoux D" first="Diana F." last="Roucoux">Diana F. Roucoux</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hoppin, Jane A" sort="Hoppin, Jane A" uniqKey="Hoppin J" first="Jane A." last="Hoppin">Jane A. Hoppin</name>
<affiliation><inist:fA14 i1="02"><s1>Epidemiology Branch</s1>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Sandler, Dale P" sort="Sandler, Dale P" uniqKey="Sandler D" first="Dale P." last="Sandler">Dale P. Sandler</name>
<affiliation><inist:fA14 i1="02"><s1>Epidemiology Branch</s1>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="William Langston, J" sort="William Langston, J" uniqKey="William Langston J" first="J." last="William Langston">J. William Langston</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<affiliation><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Craniocerebral</term>
<term>Head trauma</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Traumatisme crânien</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Crânioencéphalique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α-synuclein, modifies the association between head injury and Parkinson's disease (PD) risk. Methods: Participants in the Farming and Movement Evaluation (FAME) and the Study of Environmental Association and Risk of Parkinsonism using Case-Control Historical Interviews (SEARCH), 2 independent case-control studies, were genotyped for Rep1 and interviewed regarding head injuries with loss of consciousness or concussion prior to Parkinson's disease (PD) diagnosis. Logistic regression modeling adjusted for potential confounding variables and tested interaction between Rep1 genotype and head injury. Results: Consistent with prior reports, relative to medium-length Rep1, short Rep1 genotype was associated with reduced PD risk (pooled odds ratio [OR], 0.7; 95% confidence interval [CI], 0.5-0.9), and long Rep1 with increased risk (pooled OR, 1.4; 95% CI, 0.95-2.2). Overall, head injury was not significantly associated with PD (pooled OR, 1.3; 95% CI, 0.9-1.8). However, head injury was strongly associated with PD in those with long Rep1 (FAME OR, 5.4; 95% CI, 1.5-19; SEARCH OR, 2.3; 95% CI, 0.6-9.2; pooled OR, 3.5; 95% CI 1.4-9.2, p-interaction = 0.02). Individuals with both head injury and long Rep1 were diagnosed 4.9 years earlier than those with neither risk factor (p = 0.03). Interpretation: While head injury alone was not associated with PD risk, our data suggest head injury may initiate and/or accelerate neurodegeneration when levels of synuclein are high, as in those with Rep1 expansion. Given the high population frequency of head injury, independent verification of these results is essential.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0364-5134</s0>
</fA01>
<fA02 i1="01"><s0>ANNED3</s0>
</fA02>
<fA03 i2="1"><s0>Ann. neurol.</s0>
</fA03>
<fA05><s2>71</s2>
</fA05>
<fA06><s2>1</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Head Injury, Alpha-Synuclein Rep1, and Parkinson's Disease</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>GOLDMAN (Samuel M.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>KAMEL (Freya)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>WEBSTER ROSS (G.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>JEWELL (Sarah A.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>BHUDHIKANOK (Grace S.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>UMBACH (David)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>MARRAS (Connie)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>HAUSER (Robert A.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>JANKOVIC (Joseph)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>FACTOR (Stewart A.)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>BRESSMAN (Susan)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>LYONS (Kelly E.)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>MENG (Cheryl)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>KORELL (Monica)</s1>
</fA11>
<fA11 i1="15" i2="1"><s1>ROUCOUX (Diana F.)</s1>
</fA11>
<fA11 i1="16" i2="1"><s1>HOPPIN (Jane A.)</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>SANDLER (Dale P.)</s1>
</fA11>
<fA11 i1="18" i2="1"><s1>WILLIAM LANGSTON (J.)</s1>
</fA11>
<fA11 i1="19" i2="1"><s1>TANNER (Caroline M.)</s1>
</fA11>
<fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, CA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Epidemiology Branch</s1>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, DHHS</s1>
<s2>Research Triangle Park, NC;</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Veterans Affairs Pacific Islands Health Care System</s1>
<s2>Honolulu, HI</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>DZNE, German Center for Neurodegenerative Diseases</s1>
<s2>Bonn</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Neurology, Toronto Western Hospital, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Neurology, University of South Florida</s1>
<s2>Tampa, FL</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, TX</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Department of Neurology, Emory University School of Medicine</s1>
<s2>Atlanta, GA;</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Department of Neurology, Beth Israel Medical Center</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Department of Neurology, University of Kansas Medical Center</s1>
<s2>Kansas City, KS</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</fA14>
<fA20><s1>40-48</s1>
</fA20>
<fA21><s1>2012</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>16555</s2>
<s5>354000508658160070</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>68 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>12-0075975</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Annals of neurology</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Objective: To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α-synuclein, modifies the association between head injury and Parkinson's disease (PD) risk. Methods: Participants in the Farming and Movement Evaluation (FAME) and the Study of Environmental Association and Risk of Parkinsonism using Case-Control Historical Interviews (SEARCH), 2 independent case-control studies, were genotyped for Rep1 and interviewed regarding head injuries with loss of consciousness or concussion prior to Parkinson's disease (PD) diagnosis. Logistic regression modeling adjusted for potential confounding variables and tested interaction between Rep1 genotype and head injury. Results: Consistent with prior reports, relative to medium-length Rep1, short Rep1 genotype was associated with reduced PD risk (pooled odds ratio [OR], 0.7; 95% confidence interval [CI], 0.5-0.9), and long Rep1 with increased risk (pooled OR, 1.4; 95% CI, 0.95-2.2). Overall, head injury was not significantly associated with PD (pooled OR, 1.3; 95% CI, 0.9-1.8). However, head injury was strongly associated with PD in those with long Rep1 (FAME OR, 5.4; 95% CI, 1.5-19; SEARCH OR, 2.3; 95% CI, 0.6-9.2; pooled OR, 3.5; 95% CI 1.4-9.2, p-interaction = 0.02). Individuals with both head injury and long Rep1 were diagnosed 4.9 years earlier than those with neither risk factor (p = 0.03). Interpretation: While head injury alone was not associated with PD risk, our data suggest head injury may initiate and/or accelerate neurodegeneration when levels of synuclein are high, as in those with Rep1 expansion. Given the high population frequency of head injury, independent verification of these results is essential.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Traumatisme crânien</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Head trauma</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Traumatismo craneoencefálico</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Crânioencéphalique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Craniocerebral</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Craneoencefálico</s0>
<s5>09</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>38</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>38</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
</fC07>
<fN21><s1>058</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 12-0075975 INIST</NO>
<ET>Head Injury, Alpha-Synuclein Rep1, and Parkinson's Disease</ET>
<AU>GOLDMAN (Samuel M.); KAMEL (Freya); WEBSTER ROSS (G.); JEWELL (Sarah A.); BHUDHIKANOK (Grace S.); UMBACH (David); MARRAS (Connie); HAUSER (Robert A.); JANKOVIC (Joseph); FACTOR (Stewart A.); BRESSMAN (Susan); LYONS (Kelly E.); MENG (Cheryl); KORELL (Monica); ROUCOUX (Diana F.); HOPPIN (Jane A.); SANDLER (Dale P.); WILLIAM LANGSTON (J.); TANNER (Caroline M.)</AU>
<AF>The Parkinson's Institute/Sunnyvale, CA/Etats-Unis (1 aut., 4 aut., 5 aut., 13 aut., 14 aut., 15 aut., 18 aut., 19 aut.); Epidemiology Branch/Etats-Unis (2 aut., 16 aut., 17 aut.); Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, DHHS/Research Triangle Park, NC;/Etats-Unis (6 aut.); Veterans Affairs Pacific Islands Health Care System/Honolulu, HI/Etats-Unis (3 aut.); DZNE, German Center for Neurodegenerative Diseases/Bonn/Allemagne (4 aut.); Neurology, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (7 aut.); Department of Neurology, University of South Florida/Tampa, FL/Etats-Unis (8 aut.); Department of Neurology, Baylor College of Medicine/Houston, TX/Etats-Unis (9 aut.); Department of Neurology, Emory University School of Medicine/Atlanta, GA;/Etats-Unis (10 aut.); Department of Neurology, Beth Israel Medical Center/New York, NY/Etats-Unis (11 aut.); Department of Neurology, University of Kansas Medical Center/Kansas City, KS/Etats-Unis (12 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Annals of neurology; ISSN 0364-5134; Coden ANNED3; Etats-Unis; Da. 2012; Vol. 71; No. 1; Pp. 40-48; Bibl. 68 ref.</SO>
<LA>Anglais</LA>
<EA>Objective: To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α-synuclein, modifies the association between head injury and Parkinson's disease (PD) risk. Methods: Participants in the Farming and Movement Evaluation (FAME) and the Study of Environmental Association and Risk of Parkinsonism using Case-Control Historical Interviews (SEARCH), 2 independent case-control studies, were genotyped for Rep1 and interviewed regarding head injuries with loss of consciousness or concussion prior to Parkinson's disease (PD) diagnosis. Logistic regression modeling adjusted for potential confounding variables and tested interaction between Rep1 genotype and head injury. Results: Consistent with prior reports, relative to medium-length Rep1, short Rep1 genotype was associated with reduced PD risk (pooled odds ratio [OR], 0.7; 95% confidence interval [CI], 0.5-0.9), and long Rep1 with increased risk (pooled OR, 1.4; 95% CI, 0.95-2.2). Overall, head injury was not significantly associated with PD (pooled OR, 1.3; 95% CI, 0.9-1.8). However, head injury was strongly associated with PD in those with long Rep1 (FAME OR, 5.4; 95% CI, 1.5-19; SEARCH OR, 2.3; 95% CI, 0.6-9.2; pooled OR, 3.5; 95% CI 1.4-9.2, p-interaction = 0.02). Individuals with both head injury and long Rep1 were diagnosed 4.9 years earlier than those with neither risk factor (p = 0.03). Interpretation: While head injury alone was not associated with PD risk, our data suggest head injury may initiate and/or accelerate neurodegeneration when levels of synuclein are high, as in those with Rep1 expansion. Given the high population frequency of head injury, independent verification of these results is essential.</EA>
<CC>002B17; 002B17G</CC>
<FD>Traumatisme crânien; Maladie de Parkinson; Pathologie du système nerveux; Crânioencéphalique</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Head trauma; Parkinson disease; Nervous system diseases; Craniocerebral</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Traumatismo craneoencefálico; Parkinson enfermedad; Sistema nervioso patología; Craneoencefálico</SD>
<LO>INIST-16555.354000508658160070</LO>
<ID>12-0075975</ID>
</server>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PascalFrancis/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000232 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 000232 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    PascalFrancis
   |étape=   Corpus
   |type=    RBID
   |clé=     Pascal:12-0075975
   |texte=   Head Injury, Alpha-Synuclein Rep1, and Parkinson's Disease
}}

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Head Injury, Alpha-Synuclein Rep1, and Parkinson's Disease

Head Injury, Alpha-Synuclein Rep1, and Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Notice en format standard (ISO 2709)

Format Inist (serveur)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri