Loss of Harvey ras heterozygosity in oral squamous carcinoma
Identifieur interne : 000C22 ( Istex/Curation ); précédent : 000C21; suivant : 000C23Loss of Harvey ras heterozygosity in oral squamous carcinoma
Auteurs : R. E. Howell [Canada] ; F. S. H. Wong [Canada] ; R. G. Fenwick [Canada]Source :
- Journal of Oral Pathology & Medicine [ 0904-2512 ] ; 1989-02.
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Abstract
This investigation of oral squamous carcinoma in five individuals revealed that four of the patients were constitutionally heterozygous at the c‐Ha‐ras‐1 locus and that the tumour from one patient had lost that heterozygosity. The loss of c‐Ha‐ras‐1 alleles provides a useful marker for detecting deletions of genetic material located on the short arm of chromosome 11 (lip) and has been found in association with a number of malignant tumours but has not been previously described in carcinoma of the head and neck. The repeated association of lip deletions with malignancies has led to the postulation of a recessive cancer gene or tumour suppressor gene at this location involved in carcinogenesis and tumour progression. This study indicates that such a mechanism may contribute to the development of oral squamous carcinoma.
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DOI: 10.1111/j.1600-0714.1989.tb00741.x
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Howell, Department of Oral Biology, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation></author><author><name sortKey="Wong, F S H" sort="Wong, F S H" uniqKey="Wong F" first="F. S. H." last="Wong">F. S. H. Wong</name><affiliation wicri:level="1"><mods:affiliation>Department of Otolaryngology, Dalhousie University, Halifax, Nova Scotia, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Otolaryngology, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation></author><author><name sortKey="Fenwick, R G" sort="Fenwick, R G" uniqKey="Fenwick R" first="R. G." last="Fenwick">R. G. Fenwick</name><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada.</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0A672E1BDBB12ACC7C4D69CAA96D56992781C301</idno><date when="1989" year="1989">1989</date><idno type="doi">10.1111/j.1600-0714.1989.tb00741.x</idno><idno type="url">https://api-v5.istex.fr/document/0A672E1BDBB12ACC7C4D69CAA96D56992781C301/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000C22</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C22</idno><idno type="wicri:Area/Istex/Curation">000C22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Loss of Harvey ras heterozygosity in oral squamous carcinoma</title><author><name sortKey="Howell, R E" sort="Howell, R E" uniqKey="Howell R" first="R. E." last="Howell">R. E. Howell</name><affiliation wicri:level="1"><mods:affiliation>Department of Oral Biology, Dalhousie University, Halifax, Nova Scotia, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Oral Biology, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>R. E. Howell, Department of Oral Biology, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5</mods:affiliation><country>Canada</country><wicri:regionArea>R. E. Howell, Department of Oral Biology, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation></author><author><name sortKey="Wong, F S H" sort="Wong, F S H" uniqKey="Wong F" first="F. S. H." last="Wong">F. S. H. Wong</name><affiliation wicri:level="1"><mods:affiliation>Department of Otolaryngology, Dalhousie University, Halifax, Nova Scotia, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Otolaryngology, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation></author><author><name sortKey="Fenwick, R G" sort="Fenwick, R G" uniqKey="Fenwick R" first="R. G." last="Fenwick">R. G. Fenwick</name><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada.</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Oral Pathology & Medicine</title><idno type="ISSN">0904-2512</idno><idno type="eISSN">1600-0714</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1989-02">1989-02</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="79">79</biblScope><biblScope unit="page" to="83">83</biblScope></imprint><idno type="ISSN">0904-2512</idno></series><idno type="istex">0A672E1BDBB12ACC7C4D69CAA96D56992781C301</idno><idno type="DOI">10.1111/j.1600-0714.1989.tb00741.x</idno><idno type="ArticleID">JOP79</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0904-2512</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>carcinoma, oral</term><term>mouth, neoplasms</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This investigation of oral squamous carcinoma in five individuals revealed that four of the patients were constitutionally heterozygous at the c‐Ha‐ras‐1 locus and that the tumour from one patient had lost that heterozygosity. The loss of c‐Ha‐ras‐1 alleles provides a useful marker for detecting deletions of genetic material located on the short arm of chromosome 11 (lip) and has been found in association with a number of malignant tumours but has not been previously described in carcinoma of the head and neck. The repeated association of lip deletions with malignancies has led to the postulation of a recessive cancer gene or tumour suppressor gene at this location involved in carcinogenesis and tumour progression. This study indicates that such a mechanism may contribute to the development of oral squamous carcinoma.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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