Loss of Harvey ras heterozygosity in oral squamous carcinoma
Identifieur interne : 000C22 ( Istex/Corpus ); précédent : 000C21; suivant : 000C23Loss of Harvey ras heterozygosity in oral squamous carcinoma
Auteurs : R. E. Howell ; F. S. H. Wong ; R. G. FenwickSource :
- Journal of Oral Pathology & Medicine [ 0904-2512 ] ; 1989-02.
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Abstract
This investigation of oral squamous carcinoma in five individuals revealed that four of the patients were constitutionally heterozygous at the c‐Ha‐ras‐1 locus and that the tumour from one patient had lost that heterozygosity. The loss of c‐Ha‐ras‐1 alleles provides a useful marker for detecting deletions of genetic material located on the short arm of chromosome 11 (lip) and has been found in association with a number of malignant tumours but has not been previously described in carcinoma of the head and neck. The repeated association of lip deletions with malignancies has led to the postulation of a recessive cancer gene or tumour suppressor gene at this location involved in carcinogenesis and tumour progression. This study indicates that such a mechanism may contribute to the development of oral squamous carcinoma.
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DOI: 10.1111/j.1600-0714.1989.tb00741.x
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ISTEX:0A672E1BDBB12ACC7C4D69CAA96D56992781C301Le document en format XML
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Howell</name><affiliation><mods:affiliation>Department of Oral Biology, Dalhousie University, Halifax, Nova Scotia, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>R. E. Howell, Department of Oral Biology, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5</mods:affiliation></affiliation></author><author><name sortKey="Wong, F S H" sort="Wong, F S H" uniqKey="Wong F" first="F. S. H." last="Wong">F. S. H. Wong</name><affiliation><mods:affiliation>Department of Otolaryngology, Dalhousie University, Halifax, Nova Scotia, Canada</mods:affiliation></affiliation></author><author><name sortKey="Fenwick, R G" sort="Fenwick, R G" uniqKey="Fenwick R" first="R. G." last="Fenwick">R. G. 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The loss of c‐Ha‐ras‐1 alleles provides a useful marker for detecting deletions of genetic material located on the short arm of chromosome 11 (lip) and has been found in association with a number of malignant tumours but has not been previously described in carcinoma of the head and neck. The repeated association of lip deletions with malignancies has led to the postulation of a recessive cancer gene or tumour suppressor gene at this location involved in carcinogenesis and tumour progression. This study indicates that such a mechanism may contribute to the development of oral squamous carcinoma.</abstract><subject lang="en"><genre>keywords</genre><topic>carcinoma, oral</topic><topic>mouth, neoplasms</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Oral Pathology & Medicine</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0904-2512</identifier><identifier type="eISSN">1600-0714</identifier><identifier type="DOI">10.1111/(ISSN)1600-0714</identifier><identifier type="PublisherID">JOP</identifier><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>79</start><end>83</end><total>5</total></extent></part></relatedItem><identifier type="istex">0A672E1BDBB12ACC7C4D69CAA96D56992781C301</identifier><identifier type="DOI">10.1111/j.1600-0714.1989.tb00741.x</identifier><identifier type="ArticleID">JOP79</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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