Subdural motor cortex stimulation in Parkinson's disease does not modify movement‐related rCBF pattern
Identifieur interne : 000652 ( Istex/Corpus ); précédent : 000651; suivant : 000653Subdural motor cortex stimulation in Parkinson's disease does not modify movement‐related rCBF pattern
Auteurs : Antonio P. Strafella ; Andres M. Lozano ; Anthony E. Lang ; Ji Hyun Ko ; Yu-Yan Poon ; Elena MoroSource :
- Movement Disorders [ 0885-3185 ] ; 2007-10-31.
English descriptors
Abstract
There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [15O] H2O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF‐condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement‐related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement‐related activation pattern in patients with advanced PD. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21691
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ISTEX:D3897FB9489C036EA710288FFEC9D88A1F7DF129Le document en format XML
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Strafella</name><affiliation><mods:affiliation>Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>PET Imaging Centre, Centre for Addiction Mental Health, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Movement Disorders Centre, Toronto Western Hospital and Research Institute, CAMH‐PET imaging Centre, University of Toronto, 399 Bathurst St., Toronto, ON M5T 2S8, Canada</mods:affiliation></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. 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This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [15O] H2O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF‐condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement‐related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement‐related activation pattern in patients with advanced PD. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Antonio P. Strafella MD, PhD</name><affiliations><json:string>Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</json:string><json:string>PET Imaging Centre, Centre for Addiction Mental Health, University of Toronto, Toronto, Ontario, Canada</json:string><json:string>Movement Disorders Centre, Toronto Western Hospital and Research Institute, CAMH‐PET imaging Centre, University of Toronto, 399 Bathurst St., Toronto, ON M5T 2S8, Canada</json:string></affiliations></json:item><json:item><name>Andres M. 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disease</keyword><keyword xml:id="kwd3">PET</keyword><keyword xml:id="kwd4">functional imaging</keyword></keywordGroup><fundingInfo><fundingAgency>Parkinson's Society of Canada to EM</fundingAgency></fundingInfo><fundingInfo><fundingAgency>CIHR New Investigator Research Award</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [<sup>15</sup>O] H<sub>2</sub>O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF‐condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement‐related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement‐related activation pattern in patients with advanced PD. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Subdural motor cortex stimulation in Parkinson's disease does not modify movement‐related rCBF pattern</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Motor Cortex Stimulation and PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Subdural motor cortex stimulation in Parkinson's disease does not modify movement‐related rCBF pattern</title></titleInfo><name type="personal"><namePart type="given">Antonio P.</namePart><namePart type="family">Strafella</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</affiliation><affiliation>PET Imaging Centre, Centre for Addiction Mental Health, University of Toronto, Toronto, Ontario, Canada</affiliation><affiliation>Movement Disorders Centre, Toronto Western Hospital and Research Institute, CAMH‐PET imaging Centre, University of Toronto, 399 Bathurst St., Toronto, ON M5T 2S8, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andres M.</namePart><namePart type="family">Lozano</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anthony E.</namePart><namePart type="family">Lang</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ji Hyun</namePart><namePart type="family">Ko</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yu‐Yan</namePart><namePart type="family">Poon</namePart><namePart type="termsOfAddress">RN</namePart><affiliation>Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elena</namePart><namePart type="family">Moro</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-10-31</dateIssued><dateCaptured encoding="w3cdtf">2007-03-06</dateCaptured><dateValid encoding="w3cdtf">2007-07-03</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">1</extent><extent unit="references">27</extent><extent unit="words">3019</extent></physicalDescription><abstract lang="en">There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [15O] H2O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF‐condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement‐related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement‐related activation pattern in patients with advanced PD. © 2007 Movement Disorder Society</abstract><note type="funding">Parkinson's Society of Canada to EM</note><note type="funding">CIHR New Investigator Research Award</note><subject lang="en"><genre>keywords</genre><topic>motor cortex stimulation</topic><topic>Parkinson's disease</topic><topic>PET</topic><topic>functional imaging</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>14</number></detail><extent unit="pages"><start>2113</start><end>2116</end><total>4</total></extent></part></relatedItem><identifier type="istex">D3897FB9489C036EA710288FFEC9D88A1F7DF129</identifier><identifier type="DOI">10.1002/mds.21691</identifier><identifier type="ArticleID">MDS21691</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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