Immune response in highly active young men to the 2014/2015 seasonal influenza vaccine.
Identifieur interne : 000054 ( Main/Corpus ); précédent : 000053; suivant : 000055Immune response in highly active young men to the 2014/2015 seasonal influenza vaccine.
Auteurs : Andrew Stewart ; Otto G. Vanderkooi ; Raylene A. Reimer ; Patricia K. Doyle-BakerSource :
- Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [ 1715-5320 ] ; 2018.
English descriptors
- KwdEn :
- Absorptiometry, Photon, Adiposity, Adolescent, Adult, Age Factors, Alberta, Antibodies, Viral (blood), Healthy Volunteers, Humans, Immunogenicity, Vaccine, Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (prevention & control), Influenza, Human (virology), Male, Physical Fitness, Pilot Projects, Prospective Studies, Seasons, Seroconversion, Sex Factors, Time Factors, Vaccination, Young Adult.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Influenza Vaccines.
- immunology : Influenza, Human.
- prevention & control : Influenza, Human.
- virology : Influenza, Human.
- Absorptiometry, Photon, Adiposity, Adolescent, Adult, Age Factors, Alberta, Healthy Volunteers, Humans, Immunogenicity, Vaccine, Male, Physical Fitness, Pilot Projects, Prospective Studies, Seasons, Seroconversion, Sex Factors, Time Factors, Vaccination, Young Adult.
Abstract
During the 2009 H1N1 pandemic, individuals with obesity were disproportionately affected by H1N1 with increased levels of mortality and morbidity. This led to questions regarding the potential impact of lifestyle on the effectiveness of immunization. Currently, the research is limited on influenza vaccination and the associated changes in immune response with body composition and physical activity. The purpose of this pilot study was to investigate the potential role of adiposity and physical activity in the immune response elicited by the 2014/2015 seasonal trivalent influenza vaccine. A prospective cohort study examining the 2014/2015 seasonal trivalent influenza vaccine was conducted by collecting baseline and 4-week postvaccination fasting blood samples from 45 male Albertans between the ages of 18 and 35 years. Percent body fat (%BF) was assessed through dual X-ray absorptiometry imagining and physical activity through self-reported survey scores. While no differences in median %BF were associated with seroconversion rates in participants, the median physical activity score was higher among those that did not seroconvert to the vaccine. Significant differences were found for the A/Texas strain (p < 0.01) and a similar trend of lower magnitude observed for the remaining 2 influenza strains. These results suggest that higher physical activity levels may influence immune response to vaccination and that assessing factors beyond those commonly used can be of value when identifying vaccine response in the population.
DOI: 10.1139/apnm-2017-0683
PubMed: 29481760
Links to Exploration step
pubmed:29481760Le document en format XML
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<affiliation><nlm:affiliation>a Human Performance Lab, Faculty of Kinesiology, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada.</nlm:affiliation>
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<author><name sortKey="Vanderkooi, Otto G" sort="Vanderkooi, Otto G" uniqKey="Vanderkooi O" first="Otto G" last="Vanderkooi">Otto G. Vanderkooi</name>
<affiliation><nlm:affiliation>b Departments of Paediatrics, Pathology & Laboratory Medicine, Microbiology & Infectious diseases, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.</nlm:affiliation>
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<author><name sortKey="Reimer, Raylene A" sort="Reimer, Raylene A" uniqKey="Reimer R" first="Raylene A" last="Reimer">Raylene A. Reimer</name>
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<affiliation><nlm:affiliation>c Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.</nlm:affiliation>
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<author><name sortKey="Doyle Baker, Patricia K" sort="Doyle Baker, Patricia K" uniqKey="Doyle Baker P" first="Patricia K" last="Doyle-Baker">Patricia K. Doyle-Baker</name>
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<term>Alberta</term>
<term>Antibodies, Viral (blood)</term>
<term>Healthy Volunteers</term>
<term>Humans</term>
<term>Immunogenicity, Vaccine</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Influenza, Human (virology)</term>
<term>Male</term>
<term>Physical Fitness</term>
<term>Pilot Projects</term>
<term>Prospective Studies</term>
<term>Seasons</term>
<term>Seroconversion</term>
<term>Sex Factors</term>
<term>Time Factors</term>
<term>Vaccination</term>
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<term>Pilot Projects</term>
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<front><div type="abstract" xml:lang="en">During the 2009 H1N1 pandemic, individuals with obesity were disproportionately affected by H1N1 with increased levels of mortality and morbidity. This led to questions regarding the potential impact of lifestyle on the effectiveness of immunization. Currently, the research is limited on influenza vaccination and the associated changes in immune response with body composition and physical activity. The purpose of this pilot study was to investigate the potential role of adiposity and physical activity in the immune response elicited by the 2014/2015 seasonal trivalent influenza vaccine. A prospective cohort study examining the 2014/2015 seasonal trivalent influenza vaccine was conducted by collecting baseline and 4-week postvaccination fasting blood samples from 45 male Albertans between the ages of 18 and 35 years. Percent body fat (%BF) was assessed through dual X-ray absorptiometry imagining and physical activity through self-reported survey scores. While no differences in median %BF were associated with seroconversion rates in participants, the median physical activity score was higher among those that did not seroconvert to the vaccine. Significant differences were found for the A/Texas strain (p < 0.01) and a similar trend of lower magnitude observed for the remaining 2 influenza strains. These results suggest that higher physical activity levels may influence immune response to vaccination and that assessing factors beyond those commonly used can be of value when identifying vaccine response in the population.</div>
</front>
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<Title>Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme</Title>
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<ArticleTitle>Immune response in highly active young men to the 2014/2015 seasonal influenza vaccine.</ArticleTitle>
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<Abstract><AbstractText>During the 2009 H1N1 pandemic, individuals with obesity were disproportionately affected by H1N1 with increased levels of mortality and morbidity. This led to questions regarding the potential impact of lifestyle on the effectiveness of immunization. Currently, the research is limited on influenza vaccination and the associated changes in immune response with body composition and physical activity. The purpose of this pilot study was to investigate the potential role of adiposity and physical activity in the immune response elicited by the 2014/2015 seasonal trivalent influenza vaccine. A prospective cohort study examining the 2014/2015 seasonal trivalent influenza vaccine was conducted by collecting baseline and 4-week postvaccination fasting blood samples from 45 male Albertans between the ages of 18 and 35 years. Percent body fat (%BF) was assessed through dual X-ray absorptiometry imagining and physical activity through self-reported survey scores. While no differences in median %BF were associated with seroconversion rates in participants, the median physical activity score was higher among those that did not seroconvert to the vaccine. Significant differences were found for the A/Texas strain (p < 0.01) and a similar trend of lower magnitude observed for the remaining 2 influenza strains. These results suggest that higher physical activity levels may influence immune response to vaccination and that assessing factors beyond those commonly used can be of value when identifying vaccine response in the population.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stewart</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>a Human Performance Lab, Faculty of Kinesiology, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada.</Affiliation>
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<Author ValidYN="Y"><LastName>Vanderkooi</LastName>
<ForeName>Otto G</ForeName>
<Initials>OG</Initials>
<AffiliationInfo><Affiliation>b Departments of Paediatrics, Pathology & Laboratory Medicine, Microbiology & Infectious diseases, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Reimer</LastName>
<ForeName>Raylene A</ForeName>
<Initials>RA</Initials>
<AffiliationInfo><Affiliation>a Human Performance Lab, Faculty of Kinesiology, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>c Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Doyle-Baker</LastName>
<ForeName>Patricia K</ForeName>
<Initials>PK</Initials>
<AffiliationInfo><Affiliation>a Human Performance Lab, Faculty of Kinesiology, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>d Faculty of Environmental Design, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada.</Affiliation>
</AffiliationInfo>
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<MeshHeading><DescriptorName UI="D000071497" MajorTopicYN="Y">Immunogenicity, Vaccine</DescriptorName>
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<MeshHeading><DescriptorName UI="D000069078" MajorTopicYN="N">Seroconversion</DescriptorName>
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<MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName>
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<Keyword MajorTopicYN="N">adiposity</Keyword>
<Keyword MajorTopicYN="N">adiposité</Keyword>
<Keyword MajorTopicYN="N">influenza</Keyword>
<Keyword MajorTopicYN="N">jeunes hommes</Keyword>
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