Identification of flavonoids with trypsin inhibitory activity extracted from orange peel and green tea leaves.
Identifieur interne : 000478 ( PubMed/Curation ); précédent : 000477; suivant : 000479Identification of flavonoids with trypsin inhibitory activity extracted from orange peel and green tea leaves.
Auteurs : Durre Shahwar [Pakistan] ; Muhammad A. Raza ; Atta-Ur-RahmanSource :
- Journal of the science of food and agriculture [ 1097-0010 ] ; 2013.
English descriptors
- KwdEn :
- Camellia sinensis (chemistry), Catechin (isolation & purification), Catechin (pharmacology), Citrus sinensis (chemistry), Dietary Supplements, Flavonoids (isolation & purification), Flavonoids (pharmacology), Fruit (chemistry), Hesperidin (isolation & purification), Hesperidin (pharmacology), Humans, Inhibitory Concentration 50, Plant Leaves (chemistry), Rutin (isolation & purification), Rutin (pharmacology), Trypsin (metabolism), Trypsin Inhibitors (isolation & purification), Trypsin Inhibitors (pharmacology).
- MESH :
- chemical , isolation & purification : Catechin, Flavonoids, Hesperidin, Rutin, Trypsin Inhibitors.
- chemistry : Camellia sinensis, Citrus sinensis, Fruit, Plant Leaves.
- chemical , metabolism : Trypsin.
- chemical , pharmacology : Catechin, Flavonoids, Hesperidin, Rutin, Trypsin Inhibitors.
- Dietary Supplements, Humans, Inhibitory Concentration 50.
Abstract
Orange peel (Citrus sinensis) and green tea (Camellia sinensis) leaves, rich sources of food flavonoids, were analyzed for their trypsin inhibitory potential. Hesperetin, rutin and hesperidin from orange peel, and catechin from green tea leaves, were isolated and their chemical structures were analyzed. All four compounds were evaluated for their trypsin inhibitory potential.
DOI: 10.1002/jsfa.5910
PubMed: 23124490
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of flavonoids with trypsin inhibitory activity extracted from orange peel and green tea leaves.</title><author><name sortKey="Shahwar, Durre" sort="Shahwar, Durre" uniqKey="Shahwar D" first="Durre" last="Shahwar">Durre Shahwar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, Government College University, Lahore, Pakistan. drdshahwar@yahoo.com</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Chemistry, Government College University, Lahore</wicri:regionArea></affiliation></author><author><name sortKey="Raza, Muhammad A" sort="Raza, Muhammad A" uniqKey="Raza M" first="Muhammad A" last="Raza">Muhammad A. Raza</name></author><author><name sortKey="Atta Ur Rahman" sort="Atta Ur Rahman" uniqKey="Atta Ur Rahman" last="Atta-Ur-Rahman">Atta-Ur-Rahman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23124490</idno><idno type="pmid">23124490</idno><idno type="doi">10.1002/jsfa.5910</idno><idno type="wicri:Area/PubMed/Corpus">000478</idno><idno type="wicri:Area/PubMed/Curation">000478</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Identification of flavonoids with trypsin inhibitory activity extracted from orange peel and green tea leaves.</title><author><name sortKey="Shahwar, Durre" sort="Shahwar, Durre" uniqKey="Shahwar D" first="Durre" last="Shahwar">Durre Shahwar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, Government College University, Lahore, Pakistan. drdshahwar@yahoo.com</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Chemistry, Government College University, Lahore</wicri:regionArea></affiliation></author><author><name sortKey="Raza, Muhammad A" sort="Raza, Muhammad A" uniqKey="Raza M" first="Muhammad A" last="Raza">Muhammad A. Raza</name></author><author><name sortKey="Atta Ur Rahman" sort="Atta Ur Rahman" uniqKey="Atta Ur Rahman" last="Atta-Ur-Rahman">Atta-Ur-Rahman</name></author></analytic><series><title level="j">Journal of the science of food and agriculture</title><idno type="eISSN">1097-0010</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Camellia sinensis (chemistry)</term><term>Catechin (isolation & purification)</term><term>Catechin (pharmacology)</term><term>Citrus sinensis (chemistry)</term><term>Dietary Supplements</term><term>Flavonoids (isolation & purification)</term><term>Flavonoids (pharmacology)</term><term>Fruit (chemistry)</term><term>Hesperidin (isolation & purification)</term><term>Hesperidin (pharmacology)</term><term>Humans</term><term>Inhibitory Concentration 50</term><term>Plant Leaves (chemistry)</term><term>Rutin (isolation & purification)</term><term>Rutin (pharmacology)</term><term>Trypsin (metabolism)</term><term>Trypsin Inhibitors (isolation & purification)</term><term>Trypsin Inhibitors (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Catechin</term><term>Flavonoids</term><term>Hesperidin</term><term>Rutin</term><term>Trypsin Inhibitors</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Camellia sinensis</term><term>Citrus sinensis</term><term>Fruit</term><term>Plant Leaves</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Trypsin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Catechin</term><term>Flavonoids</term><term>Hesperidin</term><term>Rutin</term><term>Trypsin Inhibitors</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Dietary Supplements</term><term>Humans</term><term>Inhibitory Concentration 50</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Orange peel (Citrus sinensis) and green tea (Camellia sinensis) leaves, rich sources of food flavonoids, were analyzed for their trypsin inhibitory potential. Hesperetin, rutin and hesperidin from orange peel, and catechin from green tea leaves, were isolated and their chemical structures were analyzed. All four compounds were evaluated for their trypsin inhibitory potential.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23124490</PMID><DateCreated><Year>2013</Year><Month>8</Month><Day>2</Day></DateCreated><DateCompleted><Year>2014</Year><Month>02</Month><Day>20</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-0010</ISSN><JournalIssue CitedMedium="Internet"><Volume>93</Volume><Issue>6</Issue><PubDate><Year>2013</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Journal of the science of food and agriculture</Title><ISOAbbreviation>J. Sci. Food Agric.</ISOAbbreviation></Journal><ArticleTitle>Identification of flavonoids with trypsin inhibitory activity extracted from orange peel and green tea leaves.</ArticleTitle><Pagination><MedlinePgn>1420-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/jsfa.5910</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Orange peel (Citrus sinensis) and green tea (Camellia sinensis) leaves, rich sources of food flavonoids, were analyzed for their trypsin inhibitory potential. Hesperetin, rutin and hesperidin from orange peel, and catechin from green tea leaves, were isolated and their chemical structures were analyzed. All four compounds were evaluated for their trypsin inhibitory potential.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Among all the isolated compounds, rutin exhibited the highest protease inhibition activity (75.4 ± 0.9%) with IC50 = 16 ± 2 µmol L(-1), followed by catechin (65.3 ± 1.4%; IC50 = 83 ± 9 µmol L(-1)), hesperetin (62.1 ± 1.3%; IC50 = 104 ± 12 µmol L(-1)) and hesperidin (59.7 ± 1.1%; IC50 = 127 ± 14 µmol L(-1)). Lineweaver-Burk and Dixon plots and their secondary replots indicated that all four compounds possessed non-competitive inhibition. The Ki values of hesperetin, rutin, hesperidin and catechin were calculated as 90.2 ± 1.1, 17.5 ± 0.6, 84.2 ± 1.5 and 65.1 ± 1.5 µmol L(-1) respectively.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The present results suggest that the four isolated flavonoids can be used as a supplement in food for the treatment of pathologies associated with the degradation of a specific protein.</AbstractText><CopyrightInformation>© 2012 Society of Chemical Industry.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shahwar</LastName><ForeName>Durre</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Chemistry, Government College University, Lahore, Pakistan. drdshahwar@yahoo.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raza</LastName><ForeName>Muhammad A</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Atta-Ur-Rahman</LastName></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>Nov</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Sci Food Agric</MedlineTA><NlmUniqueID>0376334</NlmUniqueID><ISSNLinking>0022-5142</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005419">Flavonoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014361">Trypsin Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>5G06TVY3R7</RegistryNumber><NameOfSubstance UI="D012431">Rutin</NameOfSubstance></Chemical><Chemical><RegistryNumber>8R1V1STN48</RegistryNumber><NameOfSubstance UI="D002392">Catechin</NameOfSubstance></Chemical><Chemical><RegistryNumber>E750O06Y6O</RegistryNumber><NameOfSubstance UI="D006569">Hesperidin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.21.4</RegistryNumber><NameOfSubstance UI="D014357">Trypsin</NameOfSubstance></Chemical><Chemical><RegistryNumber>Q9Q3D557F1</RegistryNumber><NameOfSubstance UI="C013015">hesperetin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D028241" MajorTopicYN="N">Camellia sinensis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002392" MajorTopicYN="N">Catechin</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019587" MajorTopicYN="N">Dietary Supplements</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005419" MajorTopicYN="N">Flavonoids</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006569" MajorTopicYN="N">Hesperidin</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020128" MajorTopicYN="N">Inhibitory Concentration 50</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018515" MajorTopicYN="N">Plant Leaves</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012431" MajorTopicYN="N">Rutin</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014357" MajorTopicYN="N">Trypsin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014361" MajorTopicYN="N">Trypsin Inhibitors</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">enzyme inhibition</Keyword><Keyword MajorTopicYN="N">enzyme kinetics</Keyword><Keyword MajorTopicYN="N">medicinal plants</Keyword><Keyword MajorTopicYN="N">phenolic compounds</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>4</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>8</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>9</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>2</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23124490</ArticleId><ArticleId IdType="doi">10.1002/jsfa.5910</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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