OrangerV1, PubMed, Checkpoint, bibRecord, 000E17

Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.

Identifieur interne : 000E17 ( PubMed/Checkpoint ); précédent : 000E16; suivant : 000E18

Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.

Auteurs : Run Tian [Japon] ; Noriko Koyabu ; Hitomi Takanaga ; Hirotami Matsuo ; Hisakazu Ohtani ; Yasufumi Sawada

Source :

Pharmaceutical research [ 0724-8741 ] ; 2002.

RBID : pubmed:12134950

English descriptors

KwdEn :
- Animals, Beverages, Citrus paradisi (chemistry), Citrus sinensis (chemistry), In Vitro Techniques, Intestine, Small (metabolism), Male, P-Glycoprotein (metabolism), Plant Extracts (pharmacology), Rats, Rhodamine 123, Substrate Specificity (physiology).
MESH :
- chemical , metabolism : P-Glycoprotein.
- chemistry : Citrus paradisi, Citrus sinensis.
- metabolism : Intestine, Small.
- chemical , pharmacology : Plant Extracts.
- physiology : Substrate Specificity.
- Animals, Beverages, In Vitro Techniques, Male, Rats, Rhodamine 123.

Abstract

The aim of this study is to investigate the effects of 50% ethyl acetate extracts of grapefruit juice (GFJ) and orange juice (OJ) on the transport activity of P-glycoprotein (P-gp) in the rat small intestine.

PubMed: 12134950

Affiliations:

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pubmed:12134950

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.</title>
<author><name sortKey="Tian, Run" sort="Tian, Run" uniqKey="Tian R" first="Run" last="Tian">Run Tian</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koyabu, Noriko" sort="Koyabu, Noriko" uniqKey="Koyabu N" first="Noriko" last="Koyabu">Noriko Koyabu</name>
</author>
<author><name sortKey="Takanaga, Hitomi" sort="Takanaga, Hitomi" uniqKey="Takanaga H" first="Hitomi" last="Takanaga">Hitomi Takanaga</name>
</author>
<author><name sortKey="Matsuo, Hirotami" sort="Matsuo, Hirotami" uniqKey="Matsuo H" first="Hirotami" last="Matsuo">Hirotami Matsuo</name>
</author>
<author><name sortKey="Ohtani, Hisakazu" sort="Ohtani, Hisakazu" uniqKey="Ohtani H" first="Hisakazu" last="Ohtani">Hisakazu Ohtani</name>
</author>
<author><name sortKey="Sawada, Yasufumi" sort="Sawada, Yasufumi" uniqKey="Sawada Y" first="Yasufumi" last="Sawada">Yasufumi Sawada</name>
</author>
</titleStmt>
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<date when="2002">2002</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.</title>
<author><name sortKey="Tian, Run" sort="Tian, Run" uniqKey="Tian R" first="Run" last="Tian">Run Tian</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koyabu, Noriko" sort="Koyabu, Noriko" uniqKey="Koyabu N" first="Noriko" last="Koyabu">Noriko Koyabu</name>
</author>
<author><name sortKey="Takanaga, Hitomi" sort="Takanaga, Hitomi" uniqKey="Takanaga H" first="Hitomi" last="Takanaga">Hitomi Takanaga</name>
</author>
<author><name sortKey="Matsuo, Hirotami" sort="Matsuo, Hirotami" uniqKey="Matsuo H" first="Hirotami" last="Matsuo">Hirotami Matsuo</name>
</author>
<author><name sortKey="Ohtani, Hisakazu" sort="Ohtani, Hisakazu" uniqKey="Ohtani H" first="Hisakazu" last="Ohtani">Hisakazu Ohtani</name>
</author>
<author><name sortKey="Sawada, Yasufumi" sort="Sawada, Yasufumi" uniqKey="Sawada Y" first="Yasufumi" last="Sawada">Yasufumi Sawada</name>
</author>
</analytic>
<series><title level="j">Pharmaceutical research</title>
<idno type="ISSN">0724-8741</idno>
<imprint><date when="2002" type="published">2002</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Beverages</term>
<term>Citrus paradisi (chemistry)</term>
<term>Citrus sinensis (chemistry)</term>
<term>In Vitro Techniques</term>
<term>Intestine, Small (metabolism)</term>
<term>Male</term>
<term>P-Glycoprotein (metabolism)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Rats</term>
<term>Rhodamine 123</term>
<term>Substrate Specificity (physiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>P-Glycoprotein</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus paradisi</term>
<term>Citrus sinensis</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Intestine, Small</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Substrate Specificity</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Beverages</term>
<term>In Vitro Techniques</term>
<term>Male</term>
<term>Rats</term>
<term>Rhodamine 123</term>
</keywords>
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</teiHeader>
<front><div type="abstract" xml:lang="en">The aim of this study is to investigate the effects of 50% ethyl acetate extracts of grapefruit juice (GFJ) and orange juice (OJ) on the transport activity of P-glycoprotein (P-gp) in the rat small intestine.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12134950</PMID>
<DateCreated><Year>2002</Year>
<Month>7</Month>
<Day>23</Day>
</DateCreated>
<DateCompleted><Year>2003</Year>
<Month>01</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>11</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0724-8741</ISSN>
<JournalIssue CitedMedium="Print"><Volume>19</Volume>
<Issue>6</Issue>
<PubDate><Year>2002</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Pharmaceutical research</Title>
<ISOAbbreviation>Pharm. Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.</ArticleTitle>
<Pagination><MedlinePgn>802-9</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">The aim of this study is to investigate the effects of 50% ethyl acetate extracts of grapefruit juice (GFJ) and orange juice (OJ) on the transport activity of P-glycoprotein (P-gp) in the rat small intestine.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The efflux of P-gp substrates from rat everted sac in the absence or presence of verapamil, GFJ, OJ or erythromycin was measured. Rhodamine123, fexofenadine and saquinavir were used as P-gp substrates. P-gp expression levels in the rat jejunum and ileum were determined by Western blot analysis.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The efflux of rhodamine123 from the everted sac increased from the apex of the jejunum to the low ileum and the expression of P-gp in the ileum was 2.31-fold higher than that in the jejunum. Verapamil and the 50% GFJ and OJ extracts inhibited the efflux from the intestine of all three drugs tested. Erythromycin decreased the efflux of rhodaminel23 and fexofenadine, but did not affect the efflux of saquinavir in the intestine.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">GFJ and OJ extracts inhibited the efflux of P-gp substrates from the small intestine. Therefore, they may enhance the oral bioavailability of P-gp substrates by increasing absorption in the small intestine.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tian</LastName>
<ForeName>Run</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Koyabu</LastName>
<ForeName>Noriko</ForeName>
<Initials>N</Initials>
</Author>
<Author ValidYN="Y"><LastName>Takanaga</LastName>
<ForeName>Hitomi</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Matsuo</LastName>
<ForeName>Hirotami</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ohtani</LastName>
<ForeName>Hisakazu</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sawada</LastName>
<ForeName>Yasufumi</ForeName>
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</Author>
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<Language>ENG</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Pharm Res</MedlineTA>
<NlmUniqueID>8406521</NlmUniqueID>
<ISSNLinking>0724-8741</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020168">P-Glycoprotein</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>1N3CZ14C5O</RegistryNumber>
<NameOfSubstance UI="D020112">Rhodamine 123</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001628" MajorTopicYN="Y">Beverages</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032083" MajorTopicYN="Y">Citrus paradisi</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007421" MajorTopicYN="N">Intestine, Small</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020168" MajorTopicYN="N">P-Glycoprotein</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020112" MajorTopicYN="N">Rhodamine 123</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013379" MajorTopicYN="N">Substrate Specificity</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year>
<Month>7</Month>
<Day>24</Day>
<Hour>10</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2003</Year>
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<PublicationStatus>ppublish</PublicationStatus>
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<affiliations><list><country><li>Japon</li>
</country>
<region><li>Kyūshū</li>
<li>Préfecture de Fukuoka</li>
</region>
<settlement><li>Fukuoka</li>
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<orgName><li>Université de Kyūshū</li>
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<tree><noCountry><name sortKey="Koyabu, Noriko" sort="Koyabu, Noriko" uniqKey="Koyabu N" first="Noriko" last="Koyabu">Noriko Koyabu</name>
<name sortKey="Matsuo, Hirotami" sort="Matsuo, Hirotami" uniqKey="Matsuo H" first="Hirotami" last="Matsuo">Hirotami Matsuo</name>
<name sortKey="Ohtani, Hisakazu" sort="Ohtani, Hisakazu" uniqKey="Ohtani H" first="Hisakazu" last="Ohtani">Hisakazu Ohtani</name>
<name sortKey="Sawada, Yasufumi" sort="Sawada, Yasufumi" uniqKey="Sawada Y" first="Yasufumi" last="Sawada">Yasufumi Sawada</name>
<name sortKey="Takanaga, Hitomi" sort="Takanaga, Hitomi" uniqKey="Takanaga H" first="Hitomi" last="Takanaga">Hitomi Takanaga</name>
</noCountry>
<country name="Japon"><region name="Kyūshū"><name sortKey="Tian, Run" sort="Tian, Run" uniqKey="Tian R" first="Run" last="Tian">Run Tian</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.

Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki