Skin repair properties of d-Limonene and perillyl alcohol in murine models.
Identifieur interne : 000281 ( PubMed/Checkpoint ); précédent : 000280; suivant : 000282Skin repair properties of d-Limonene and perillyl alcohol in murine models.
Auteurs : Patrizia A. D'Alessio ; Massoud Mirshahi ; Jean-Francois Bisson ; Marie C. Bene [France]Source :
- Anti-inflammatory & anti-allergy agents in medicinal chemistry [ 1875-614X ] ; 2014.
English descriptors
- KwdEn :
- Administration, Cutaneous, Angiogenesis Inhibitors (therapeutic use), Animals, Cells, Cultured, Citrus sinensis, Cyclohexenes (therapeutic use), Cytokines (blood), Dermatitis, Irritant (drug therapy), Disease Models, Animal, Endothelium (drug effects), Endothelium (pathology), Female, Fruit, Gene Expression Regulation (drug effects), Humans, Inflammation Mediators (blood), Mice, Mice, Hairless, Microtubules (drug effects), Monoterpenes (therapeutic use), P-Selectin (metabolism), Phorbol Esters (administration & dosage), Phytotherapy, Skin (drug effects), Skin (injuries), Skin (pathology), Terpenes (therapeutic use), Wound Healing (drug effects).
- MESH :
- chemical , administration & dosage : Phorbol Esters.
- chemical , blood : Cytokines, Inflammation Mediators.
- chemical , metabolism : P-Selectin.
- chemical , therapeutic use : Angiogenesis Inhibitors, Cyclohexenes, Monoterpenes, Terpenes.
- drug effects : Endothelium, Gene Expression Regulation, Microtubules, Skin, Wound Healing.
- drug therapy : Dermatitis, Irritant.
- injuries : Skin.
- pathology : Endothelium, Skin.
- Administration, Cutaneous, Animals, Cells, Cultured, Citrus sinensis, Disease Models, Animal, Female, Fruit, Humans, Mice, Mice, Hairless, Phytotherapy.
Abstract
The orange-peel derived terpene d-Limonene, probably through its metabolite, perillyl alcohol (POH), has been reported to have tissue-repair properties. Two murine models of respectively 12-O-Tetradecanoylphorbol-13-Acetate (TPA)-induced dermatitis and mechanical skin lesion were used here to assess the efficacy of d-Limonene or POH applied topically. Macroscopic and microscopic evaluation of skin lesions was performed as well as that of P-selectin expression, together with measurements of serum concentrations of IL-1β, IL-6 and TNF-α in the first model. Healing and angiogenesis around the scar were examined in the second model. Because differences in angiogenesis were noted, the effect of both d-Limonene and POH was further tested on an in vitro model of endothelial microtubules formation. Both d-Limonene and POH reduced the severity and extension of TPA-induced skin lesions with significantly lowered macroscopic and microscopic scores (p<0.04 in both cases). Moreover, the expression of P-selectin induced by TPA was abrogated by POH and significantly lower serum concentrations of IL-6 and TNF-α were observed in d-Limonene- and POH-treated mice (p<0.04 and 0.03). In the second model, tissue regeneration was improved, especially by POH, and was clearly associated with reduced neovascularization. This surprising anti-angiogenic effect was confirmed in the matrigel model of endothelial microtubules formation. These studies show that d-Limonene and POH demonstrate significant anti-inflammatory effects in murine dermal inflammation and wound-healing. The decreased systemic cytokine production as well as a consistent inhibition of endothelial P-selectin expression and neo-vascularization induced by these terpenic compounds contribute to their healing effects on the epidermal barrier.
PubMed: 24160248
Affiliations:
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Bene</name><affiliation wicri:level="1"><nlm:affiliation>Biopark Campus Cancer, 1, mail Pr Georges Mathe, 94807 Villejuif - France. endocell@wanadoo.fr.</nlm:affiliation><country wicri:rule="url">France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24160248</idno><idno type="pmid">24160248</idno><idno type="wicri:Area/PubMed/Corpus">000358</idno><idno type="wicri:Area/PubMed/Curation">000358</idno><idno type="wicri:Area/PubMed/Checkpoint">000358</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Skin repair properties of d-Limonene and perillyl alcohol in murine models.</title><author><name sortKey="D Alessio, Patrizia A" sort="D Alessio, Patrizia A" uniqKey="D Alessio P" first="Patrizia A" last="D'Alessio">Patrizia A. D'Alessio</name></author><author><name sortKey="Mirshahi, Massoud" sort="Mirshahi, Massoud" uniqKey="Mirshahi M" first="Massoud" last="Mirshahi">Massoud Mirshahi</name></author><author><name sortKey="Bisson, Jean Francois" sort="Bisson, Jean Francois" uniqKey="Bisson J" first="Jean-Francois" last="Bisson">Jean-Francois Bisson</name></author><author><name sortKey="Bene, Marie C" sort="Bene, Marie C" uniqKey="Bene M" first="Marie C" last="Bene">Marie C. Bene</name><affiliation wicri:level="1"><nlm:affiliation>Biopark Campus Cancer, 1, mail Pr Georges Mathe, 94807 Villejuif - France. endocell@wanadoo.fr.</nlm:affiliation><country wicri:rule="url">France</country></affiliation></author></analytic><series><title level="j">Anti-inflammatory & anti-allergy agents in medicinal chemistry</title><idno type="eISSN">1875-614X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Cutaneous</term><term>Angiogenesis Inhibitors (therapeutic use)</term><term>Animals</term><term>Cells, Cultured</term><term>Citrus sinensis</term><term>Cyclohexenes (therapeutic use)</term><term>Cytokines (blood)</term><term>Dermatitis, Irritant (drug therapy)</term><term>Disease Models, Animal</term><term>Endothelium (drug effects)</term><term>Endothelium (pathology)</term><term>Female</term><term>Fruit</term><term>Gene Expression Regulation (drug effects)</term><term>Humans</term><term>Inflammation Mediators (blood)</term><term>Mice</term><term>Mice, Hairless</term><term>Microtubules (drug effects)</term><term>Monoterpenes (therapeutic use)</term><term>P-Selectin (metabolism)</term><term>Phorbol Esters (administration & dosage)</term><term>Phytotherapy</term><term>Skin (drug effects)</term><term>Skin (injuries)</term><term>Skin (pathology)</term><term>Terpenes (therapeutic use)</term><term>Wound Healing (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Phorbol Esters</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cytokines</term><term>Inflammation Mediators</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>P-Selectin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Angiogenesis Inhibitors</term><term>Cyclohexenes</term><term>Monoterpenes</term><term>Terpenes</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Endothelium</term><term>Gene Expression Regulation</term><term>Microtubules</term><term>Skin</term><term>Wound Healing</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dermatitis, Irritant</term></keywords><keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Skin</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Endothelium</term><term>Skin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Cutaneous</term><term>Animals</term><term>Cells, Cultured</term><term>Citrus sinensis</term><term>Disease Models, Animal</term><term>Female</term><term>Fruit</term><term>Humans</term><term>Mice</term><term>Mice, Hairless</term><term>Phytotherapy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The orange-peel derived terpene d-Limonene, probably through its metabolite, perillyl alcohol (POH), has been reported to have tissue-repair properties. Two murine models of respectively 12-O-Tetradecanoylphorbol-13-Acetate (TPA)-induced dermatitis and mechanical skin lesion were used here to assess the efficacy of d-Limonene or POH applied topically. Macroscopic and microscopic evaluation of skin lesions was performed as well as that of P-selectin expression, together with measurements of serum concentrations of IL-1β, IL-6 and TNF-α in the first model. Healing and angiogenesis around the scar were examined in the second model. Because differences in angiogenesis were noted, the effect of both d-Limonene and POH was further tested on an in vitro model of endothelial microtubules formation. Both d-Limonene and POH reduced the severity and extension of TPA-induced skin lesions with significantly lowered macroscopic and microscopic scores (p<0.04 in both cases). Moreover, the expression of P-selectin induced by TPA was abrogated by POH and significantly lower serum concentrations of IL-6 and TNF-α were observed in d-Limonene- and POH-treated mice (p<0.04 and 0.03). In the second model, tissue regeneration was improved, especially by POH, and was clearly associated with reduced neovascularization. This surprising anti-angiogenic effect was confirmed in the matrigel model of endothelial microtubules formation. These studies show that d-Limonene and POH demonstrate significant anti-inflammatory effects in murine dermal inflammation and wound-healing. The decreased systemic cytokine production as well as a consistent inhibition of endothelial P-selectin expression and neo-vascularization induced by these terpenic compounds contribute to their healing effects on the epidermal barrier.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24160248</PMID><DateCreated><Year>2014</Year><Month>2</Month><Day>3</Day></DateCreated><DateCompleted><Year>2014</Year><Month>10</Month><Day>01</Day></DateCompleted><DateRevised><Year>2015</Year><Month>8</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1875-614X</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>1</Issue><PubDate><Year>2014</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Anti-inflammatory & anti-allergy agents in medicinal chemistry</Title><ISOAbbreviation>Antiinflamm Antiallergy Agents Med Chem</ISOAbbreviation></Journal><ArticleTitle>Skin repair properties of d-Limonene and perillyl alcohol in murine models.</ArticleTitle><Pagination><MedlinePgn>29-35</MedlinePgn></Pagination><Abstract><AbstractText>The orange-peel derived terpene d-Limonene, probably through its metabolite, perillyl alcohol (POH), has been reported to have tissue-repair properties. Two murine models of respectively 12-O-Tetradecanoylphorbol-13-Acetate (TPA)-induced dermatitis and mechanical skin lesion were used here to assess the efficacy of d-Limonene or POH applied topically. Macroscopic and microscopic evaluation of skin lesions was performed as well as that of P-selectin expression, together with measurements of serum concentrations of IL-1β, IL-6 and TNF-α in the first model. Healing and angiogenesis around the scar were examined in the second model. Because differences in angiogenesis were noted, the effect of both d-Limonene and POH was further tested on an in vitro model of endothelial microtubules formation. Both d-Limonene and POH reduced the severity and extension of TPA-induced skin lesions with significantly lowered macroscopic and microscopic scores (p<0.04 in both cases). Moreover, the expression of P-selectin induced by TPA was abrogated by POH and significantly lower serum concentrations of IL-6 and TNF-α were observed in d-Limonene- and POH-treated mice (p<0.04 and 0.03). In the second model, tissue regeneration was improved, especially by POH, and was clearly associated with reduced neovascularization. This surprising anti-angiogenic effect was confirmed in the matrigel model of endothelial microtubules formation. These studies show that d-Limonene and POH demonstrate significant anti-inflammatory effects in murine dermal inflammation and wound-healing. The decreased systemic cytokine production as well as a consistent inhibition of endothelial P-selectin expression and neo-vascularization induced by these terpenic compounds contribute to their healing effects on the epidermal barrier.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>d'Alessio</LastName><ForeName>Patrizia A</ForeName><Initials>PA</Initials></Author><Author ValidYN="Y"><LastName>Mirshahi</LastName><ForeName>Massoud</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Bisson</LastName><ForeName>Jean-Francois</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Bene</LastName><ForeName>Marie C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Biopark Campus Cancer, 1, mail Pr Georges Mathe, 94807 Villejuif - France. endocell@wanadoo.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United Arab Emirates</Country><MedlineTA>Antiinflamm Antiallergy Agents Med Chem</MedlineTA><NlmUniqueID>101462262</NlmUniqueID><ISSNLinking>1871-5230</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020533">Angiogenesis Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053138">Cyclohexenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018836">Inflammation Mediators</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D039821">Monoterpenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019007">P-Selectin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010703">Phorbol Esters</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013729">Terpenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>319R5C7293</RegistryNumber><NameOfSubstance UI="C032208">perilla alcohol</NameOfSubstance></Chemical><Chemical><RegistryNumber>9MC3I34447</RegistryNumber><NameOfSubstance UI="C008281">limonene</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000279" MajorTopicYN="N">Administration, Cutaneous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020533" MajorTopicYN="N">Angiogenesis Inhibitors</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="Y">Citrus sinensis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053138" MajorTopicYN="N">Cyclohexenes</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017453" MajorTopicYN="N">Dermatitis, Irritant</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004727" MajorTopicYN="N">Endothelium</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018836" MajorTopicYN="N">Inflammation Mediators</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008812" MajorTopicYN="N">Mice, Hairless</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008870" MajorTopicYN="N">Microtubules</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D039821" MajorTopicYN="N">Monoterpenes</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019007" MajorTopicYN="N">P-Selectin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010703" MajorTopicYN="N">Phorbol Esters</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008517" MajorTopicYN="Y">Phytotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000293" MajorTopicYN="N">injuries</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013729" MajorTopicYN="N">Terpenes</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014945" MajorTopicYN="N">Wound Healing</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>7</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>10</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>10</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>10</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>10</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>10</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24160248</ArticleId><ArticleId IdType="pii">AIAAMC-EPUB-57007</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Bisson, Jean Francois" sort="Bisson, Jean Francois" uniqKey="Bisson J" first="Jean-Francois" last="Bisson">Jean-Francois Bisson</name><name sortKey="D Alessio, Patrizia A" sort="D Alessio, Patrizia A" uniqKey="D Alessio P" first="Patrizia A" last="D'Alessio">Patrizia A. D'Alessio</name><name sortKey="Mirshahi, Massoud" sort="Mirshahi, Massoud" uniqKey="Mirshahi M" first="Massoud" last="Mirshahi">Massoud Mirshahi</name></noCountry><country name="France"><noRegion><name sortKey="Bene, Marie C" sort="Bene, Marie C" uniqKey="Bene M" first="Marie C" last="Bene">Marie C. Bene</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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