OrangerV1, PascalFrancis, Corpus, bibRecord, 000336

Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis

Identifieur interne : 000336 ( PascalFrancis/Corpus ); précédent : 000335; suivant : 000337

Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis

Auteurs : HANG XIAO ; Chung S. Yang ; SHIMING LI ; HUANYU JIN ; Chi-Tang Ho ; Trusha Patel

Source :

Molecular nutrition & food research : (Print) [ 1613-4125 ] ; 2009.

RBID : Pascal:09-0152404

Descripteurs français

Pascal (Inist)
- Bonbon, Orange, Citrus sinensis, Pelure, Croissance, Homme, Tumeur maligne.

English descriptors

KwdEn :
- Citrus sinensis, Growth, Human, Malignant tumor, Orange, Peel, Sweets.

Abstract

Polymethoxyflavones (PMFs) are almost exclusively found in the Citrus genus, particularly in the peels of sweet orange (Citrus sinensis L. Osbeck) and mandarin (C. reticulate Blanco). We studied the effects of two major PMFs, namely, nobiletin and 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), and two major monodemethylated PMFs, namely 5-hydroxy-3,7,8,3',4'-pentamethoxyflavone (5HPMF), and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5HHMF), on the growth of human lung cancer H1299, H441, and H460 cells. Monodemethylated PMFs were much more potent in growth inhibition of lung cancer cells than their permethoxylated counterpart PMFs. In H1299 cells, cell cycle analyses further revealed that monodemethylated PMFs caused significant increase in sub-G0/ Gl phase, suggesting possible role of apoptosis in the growth inhibition observed, whereas the permethoxylated counterpart PMFs did not affect cell cycle distribution at same concentrations tested. These results strongly suggested that the phenolic group is essential for the growth inhibitory activity of monodemethylated PMFs. Further studies in H1299 cells demonstrated that monodemethylated PMFs downregulated oncogenic proteins, such as iNOS, COX-2, Mcl-1, and K-ras, as well as induced apoptosis evidenced by activation of caspase-3 and cleavage of PARP. Our results provide rationale to develop orange peel extract enriched with monodemethylated PMFs into value-added nutraceutical products for cancer prevention.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 1613-4125`
A03		`1`		`@0 Mol. nutr. food res. : (Print)`
A05				`@2 53`
A06				`@2 3`
A08	`01`	`1`	`ENG`	`@1 Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis`
A11	`01`	`1`		`@1 HANG XIAO`
A11	`02`	`1`		`@1 YANG (Chung S.)`
A11	`03`	`1`		`@1 SHIMING LI`
A11	`04`	`1`		`@1 HUANYU JIN`
A11	`05`	`1`		`@1 HO (Chi-Tang)`
A11	`06`	`1`		`@1 PATEL (Trusha)`
A14	`01`			`@1 Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey @2 Piscataway, NJ @3 USA @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 6 aut.`
A14	`02`			`@1 Department of Food Science, University of Massachusetts @2 Amherst, MA @3 USA @Z 1 aut.`
A14	`03`			`@1 WellGen, Inc @2 North Brunswick, NJ @3 USA @Z 3 aut.`
A14	`04`			`@1 Department of Food Science, Rutgers, The State University of New Jersey @2 New Brunswick, NJ @3 USA @Z 5 aut.`
A20				`@1 398-406`
A21				`@1 2009`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 9262 @5 354000185540640100`
A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
A45				`@0 33 ref.`
A47	`01`	`1`		`@0 09-0152404`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Molecular nutrition & food research : (Print)`
A66	`01`			`@0 DEU`
C01	`01`		`ENG`	@0 Polymethoxyflavones (PMFs) are almost exclusively found in the Citrus genus, particularly in the peels of sweet orange (Citrus sinensis L. Osbeck) and mandarin (C. reticulate Blanco). We studied the effects of two major PMFs, namely, nobiletin and 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), and two major monodemethylated PMFs, namely 5-hydroxy-3,7,8,3',4'-pentamethoxyflavone (5HPMF), and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5HHMF), on the growth of human lung cancer H1299, H441, and H460 cells. Monodemethylated PMFs were much more potent in growth inhibition of lung cancer cells than their permethoxylated counterpart PMFs. In H1299 cells, cell cycle analyses further revealed that monodemethylated PMFs caused significant increase in sub-G0/ Gl phase, suggesting possible role of apoptosis in the growth inhibition observed, whereas the permethoxylated counterpart PMFs did not affect cell cycle distribution at same concentrations tested. These results strongly suggested that the phenolic group is essential for the growth inhibitory activity of monodemethylated PMFs. Further studies in H1299 cells demonstrated that monodemethylated PMFs downregulated oncogenic proteins, such as iNOS, COX-2, Mcl-1, and K-ras, as well as induced apoptosis evidenced by activation of caspase-3 and cleavage of PARP. Our results provide rationale to develop orange peel extract enriched with monodemethylated PMFs into value-added nutraceutical products for cancer prevention.
C02	`01`	`X`		`@0 002A35B11`
C02	`02`	`X`		`@0 002A35B09`
C03	`01`	`X`	`FRE`	`@0 Bonbon @5 01`
C03	`01`	`X`	`ENG`	`@0 Sweets @5 01`
C03	`01`	`X`	`SPA`	`@0 Caramelo @5 01`
C03	`02`	`X`	`FRE`	`@0 Orange @5 02`
C03	`02`	`X`	`ENG`	`@0 Orange @5 02`
C03	`02`	`X`	`SPA`	`@0 Naranja @5 02`
C03	`03`	`X`	`FRE`	`@0 Citrus sinensis @2 NS @5 10`
C03	`03`	`X`	`ENG`	`@0 Citrus sinensis @2 NS @5 10`
C03	`03`	`X`	`SPA`	`@0 Citrus sinensis @2 NS @5 10`
C03	`04`	`X`	`FRE`	`@0 Pelure @5 19`
C03	`04`	`X`	`ENG`	`@0 Peel @5 19`
C03	`04`	`X`	`SPA`	`@0 Cáscara @5 19`
C03	`05`	`X`	`FRE`	`@0 Croissance @5 20`
C03	`05`	`X`	`ENG`	`@0 Growth @5 20`
C03	`05`	`X`	`SPA`	`@0 Crecimiento @5 20`
C03	`06`	`X`	`FRE`	`@0 Homme @5 24`
C03	`06`	`X`	`ENG`	`@0 Human @5 24`
C03	`06`	`X`	`SPA`	`@0 Hombre @5 24`
C03	`07`	`X`	`FRE`	`@0 Tumeur maligne @2 NM @5 26`
C03	`07`	`X`	`ENG`	`@0 Malignant tumor @2 NM @5 26`
C03	`07`	`X`	`SPA`	`@0 Tumor maligno @2 NM @5 26`
C07	`01`	`X`	`FRE`	`@0 Produit confiserie @5 08`
C07	`01`	`X`	`ENG`	`@0 Confectionery product @5 08`
C07	`01`	`X`	`SPA`	`@0 Producto confitería @5 08`
C07	`02`	`X`	`FRE`	`@0 Rutaceae @2 NS`
C07	`02`	`X`	`ENG`	`@0 Rutaceae @2 NS`
C07	`02`	`X`	`SPA`	`@0 Rutaceae @2 NS`
C07	`03`	`X`	`FRE`	`@0 Dicotyledones @2 NS`
C07	`03`	`X`	`ENG`	`@0 Dicotyledones @2 NS`
C07	`03`	`X`	`SPA`	`@0 Dicotyledones @2 NS`
C07	`04`	`X`	`FRE`	`@0 Angiospermae @2 NS`
C07	`04`	`X`	`ENG`	`@0 Angiospermae @2 NS`
C07	`04`	`X`	`SPA`	`@0 Angiospermae @2 NS`
C07	`05`	`X`	`FRE`	`@0 Spermatophyta @2 NS`
C07	`05`	`X`	`ENG`	`@0 Spermatophyta @2 NS`
C07	`05`	`X`	`SPA`	`@0 Spermatophyta @2 NS`
C07	`06`	`X`	`FRE`	`@0 Cancer @2 NM`
C07	`06`	`X`	`ENG`	`@0 Cancer @2 NM`
C07	`06`	`X`	`SPA`	`@0 Cáncer @2 NM`
C07	`07`	`X`	`FRE`	`@0 Fruit @5 49`
C07	`07`	`X`	`ENG`	`@0 Fruit @5 49`
C07	`07`	`X`	`SPA`	`@0 Fruto @5 49`
C07	`08`	`X`	`FRE`	`@0 Agrume @5 50`
C07	`08`	`X`	`ENG`	`@0 Citrus fruit @5 50`
C07	`08`	`X`	`SPA`	`@0 Agrios @5 50`
N21				`@1 110`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 09-0152404 INIST
ET :	Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis
AU :	HANG XIAO; YANG (Chung S.); SHIMING LI; HUANYU JIN; HO (Chi-Tang); PATEL (Trusha)
AF :	Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey/Piscataway, NJ/Etats-Unis (1 aut., 2 aut., 4 aut., 6 aut.); Department of Food Science, University of Massachusetts/Amherst, MA/Etats-Unis (1 aut.); WellGen, Inc/North Brunswick, NJ/Etats-Unis (3 aut.); Department of Food Science, Rutgers, The State University of New Jersey/New Brunswick, NJ/Etats-Unis (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Molecular nutrition & food research : (Print); ISSN 1613-4125; Allemagne; Da. 2009; Vol. 53; No. 3; Pp. 398-406; Bibl. 33 ref.
LA :	Anglais
EA :	Polymethoxyflavones (PMFs) are almost exclusively found in the Citrus genus, particularly in the peels of sweet orange (Citrus sinensis L. Osbeck) and mandarin (C. reticulate Blanco). We studied the effects of two major PMFs, namely, nobiletin and 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), and two major monodemethylated PMFs, namely 5-hydroxy-3,7,8,3',4'-pentamethoxyflavone (5HPMF), and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5HHMF), on the growth of human lung cancer H1299, H441, and H460 cells. Monodemethylated PMFs were much more potent in growth inhibition of lung cancer cells than their permethoxylated counterpart PMFs. In H1299 cells, cell cycle analyses further revealed that monodemethylated PMFs caused significant increase in sub-G0/ Gl phase, suggesting possible role of apoptosis in the growth inhibition observed, whereas the permethoxylated counterpart PMFs did not affect cell cycle distribution at same concentrations tested. These results strongly suggested that the phenolic group is essential for the growth inhibitory activity of monodemethylated PMFs. Further studies in H1299 cells demonstrated that monodemethylated PMFs downregulated oncogenic proteins, such as iNOS, COX-2, Mcl-1, and K-ras, as well as induced apoptosis evidenced by activation of caspase-3 and cleavage of PARP. Our results provide rationale to develop orange peel extract enriched with monodemethylated PMFs into value-added nutraceutical products for cancer prevention.
CC :	002A35B11; 002A35B09
FD :	Bonbon; Orange; Citrus sinensis; Pelure; Croissance; Homme; Tumeur maligne
FG :	Produit confiserie; Rutaceae; Dicotyledones; Angiospermae; Spermatophyta; Cancer; Fruit; Agrume
ED :	Sweets; Orange; Citrus sinensis; Peel; Growth; Human; Malignant tumor
EG :	Confectionery product; Rutaceae; Dicotyledones; Angiospermae; Spermatophyta; Cancer; Fruit; Citrus fruit
SD :	Caramelo; Naranja; Citrus sinensis; Cáscara; Crecimiento; Hombre; Tumor maligno
LO :	INIST-9262.354000185540640100
ID :	09-0152404

Links to Exploration step

Pascal:09-0152404

Le document en format XML

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<affiliation><inist:fA14 i1="02"><s1>Department of Food Science, University of Massachusetts</s1>
<s2>Amherst, MA</s2>
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<author><name sortKey="Yang, Chung S" sort="Yang, Chung S" uniqKey="Yang C" first="Chung S." last="Yang">Chung S. Yang</name>
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<front><div type="abstract" xml:lang="en">Polymethoxyflavones (PMFs) are almost exclusively found in the Citrus genus, particularly in the peels of sweet orange (Citrus sinensis L. Osbeck) and mandarin (C. reticulate Blanco). We studied the effects of two major PMFs, namely, nobiletin and 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), and two major monodemethylated PMFs, namely 5-hydroxy-3,7,8,3',4'-pentamethoxyflavone (5HPMF), and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5HHMF), on the growth of human lung cancer H1299, H441, and H460 cells. Monodemethylated PMFs were much more potent in growth inhibition of lung cancer cells than their permethoxylated counterpart PMFs. In H1299 cells, cell cycle analyses further revealed that monodemethylated PMFs caused significant increase in sub-G0/ Gl phase, suggesting possible role of apoptosis in the growth inhibition observed, whereas the permethoxylated counterpart PMFs did not affect cell cycle distribution at same concentrations tested. These results strongly suggested that the phenolic group is essential for the growth inhibitory activity of monodemethylated PMFs. Further studies in H1299 cells demonstrated that monodemethylated PMFs downregulated oncogenic proteins, such as iNOS, COX-2, Mcl-1, and K-ras, as well as induced apoptosis evidenced by activation of caspase-3 and cleavage of PARP. Our results provide rationale to develop orange peel extract enriched with monodemethylated PMFs into value-added nutraceutical products for cancer prevention.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis</s1>
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<fA11 i1="01" i2="1"><s1>HANG XIAO</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>YANG (Chung S.)</s1>
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<fA11 i1="03" i2="1"><s1>SHIMING LI</s1>
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<fA11 i1="04" i2="1"><s1>HUANYU JIN</s1>
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<fA11 i1="05" i2="1"><s1>HO (Chi-Tang)</s1>
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<fA11 i1="06" i2="1"><s1>PATEL (Trusha)</s1>
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<fA14 i1="01"><s1>Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey</s1>
<s2>Piscataway, NJ</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Food Science, University of Massachusetts</s1>
<s2>Amherst, MA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>WellGen, Inc</s1>
<s2>North Brunswick, NJ</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Food Science, Rutgers, The State University of New Jersey</s1>
<s2>New Brunswick, NJ</s2>
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<fA20><s1>398-406</s1>
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</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>9262</s2>
<s5>354000185540640100</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2009 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>33 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>09-0152404</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Molecular nutrition & food research : (Print)</s0>
</fA64>
<fA66 i1="01"><s0>DEU</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Polymethoxyflavones (PMFs) are almost exclusively found in the Citrus genus, particularly in the peels of sweet orange (Citrus sinensis L. Osbeck) and mandarin (C. reticulate Blanco). We studied the effects of two major PMFs, namely, nobiletin and 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), and two major monodemethylated PMFs, namely 5-hydroxy-3,7,8,3',4'-pentamethoxyflavone (5HPMF), and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5HHMF), on the growth of human lung cancer H1299, H441, and H460 cells. Monodemethylated PMFs were much more potent in growth inhibition of lung cancer cells than their permethoxylated counterpart PMFs. In H1299 cells, cell cycle analyses further revealed that monodemethylated PMFs caused significant increase in sub-G0/ Gl phase, suggesting possible role of apoptosis in the growth inhibition observed, whereas the permethoxylated counterpart PMFs did not affect cell cycle distribution at same concentrations tested. These results strongly suggested that the phenolic group is essential for the growth inhibitory activity of monodemethylated PMFs. Further studies in H1299 cells demonstrated that monodemethylated PMFs downregulated oncogenic proteins, such as iNOS, COX-2, Mcl-1, and K-ras, as well as induced apoptosis evidenced by activation of caspase-3 and cleavage of PARP. Our results provide rationale to develop orange peel extract enriched with monodemethylated PMFs into value-added nutraceutical products for cancer prevention.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A35B11</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002A35B09</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Bonbon</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Sweets</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Caramelo</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Orange</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Orange</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Naranja</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Citrus sinensis</s0>
<s2>NS</s2>
<s5>10</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Citrus sinensis</s0>
<s2>NS</s2>
<s5>10</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Citrus sinensis</s0>
<s2>NS</s2>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Pelure</s0>
<s5>19</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Peel</s0>
<s5>19</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Cáscara</s0>
<s5>19</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Croissance</s0>
<s5>20</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Growth</s0>
<s5>20</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Crecimiento</s0>
<s5>20</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Homme</s0>
<s5>24</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Human</s0>
<s5>24</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Hombre</s0>
<s5>24</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Tumeur maligne</s0>
<s2>NM</s2>
<s5>26</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Malignant tumor</s0>
<s2>NM</s2>
<s5>26</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Tumor maligno</s0>
<s2>NM</s2>
<s5>26</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Produit confiserie</s0>
<s5>08</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Confectionery product</s0>
<s5>08</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Producto confitería</s0>
<s5>08</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Rutaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Rutaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Rutaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Cáncer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Fruit</s0>
<s5>49</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Fruit</s0>
<s5>49</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Fruto</s0>
<s5>49</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Agrume</s0>
<s5>50</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Citrus fruit</s0>
<s5>50</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Agrios</s0>
<s5>50</s5>
</fC07>
<fN21><s1>110</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 09-0152404 INIST</NO>
<ET>Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis</ET>
<AU>HANG XIAO; YANG (Chung S.); SHIMING LI; HUANYU JIN; HO (Chi-Tang); PATEL (Trusha)</AU>
<AF>Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey/Piscataway, NJ/Etats-Unis (1 aut., 2 aut., 4 aut., 6 aut.); Department of Food Science, University of Massachusetts/Amherst, MA/Etats-Unis (1 aut.); WellGen, Inc/North Brunswick, NJ/Etats-Unis (3 aut.); Department of Food Science, Rutgers, The State University of New Jersey/New Brunswick, NJ/Etats-Unis (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Molecular nutrition & food research : (Print); ISSN 1613-4125; Allemagne; Da. 2009; Vol. 53; No. 3; Pp. 398-406; Bibl. 33 ref.</SO>
<LA>Anglais</LA>
<EA>Polymethoxyflavones (PMFs) are almost exclusively found in the Citrus genus, particularly in the peels of sweet orange (Citrus sinensis L. Osbeck) and mandarin (C. reticulate Blanco). We studied the effects of two major PMFs, namely, nobiletin and 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), and two major monodemethylated PMFs, namely 5-hydroxy-3,7,8,3',4'-pentamethoxyflavone (5HPMF), and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5HHMF), on the growth of human lung cancer H1299, H441, and H460 cells. Monodemethylated PMFs were much more potent in growth inhibition of lung cancer cells than their permethoxylated counterpart PMFs. In H1299 cells, cell cycle analyses further revealed that monodemethylated PMFs caused significant increase in sub-G0/ Gl phase, suggesting possible role of apoptosis in the growth inhibition observed, whereas the permethoxylated counterpart PMFs did not affect cell cycle distribution at same concentrations tested. These results strongly suggested that the phenolic group is essential for the growth inhibitory activity of monodemethylated PMFs. Further studies in H1299 cells demonstrated that monodemethylated PMFs downregulated oncogenic proteins, such as iNOS, COX-2, Mcl-1, and K-ras, as well as induced apoptosis evidenced by activation of caspase-3 and cleavage of PARP. Our results provide rationale to develop orange peel extract enriched with monodemethylated PMFs into value-added nutraceutical products for cancer prevention.</EA>
<CC>002A35B11; 002A35B09</CC>
<FD>Bonbon; Orange; Citrus sinensis; Pelure; Croissance; Homme; Tumeur maligne</FD>
<FG>Produit confiserie; Rutaceae; Dicotyledones; Angiospermae; Spermatophyta; Cancer; Fruit; Agrume</FG>
<ED>Sweets; Orange; Citrus sinensis; Peel; Growth; Human; Malignant tumor</ED>
<EG>Confectionery product; Rutaceae; Dicotyledones; Angiospermae; Spermatophyta; Cancer; Fruit; Citrus fruit</EG>
<SD>Caramelo; Naranja; Citrus sinensis; Cáscara; Crecimiento; Hombre; Tumor maligno</SD>
<LO>INIST-9262.354000185540640100</LO>
<ID>09-0152404</ID>
</server>
</inist>
</record>

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Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis

Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis

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