[Improvement of patient adherence by mixing oral itraconazole solution with a beverage (orange juice)].
Identifieur interne : 000B86 ( Ncbi/Merge ); précédent : 000B85; suivant : 000B87[Improvement of patient adherence by mixing oral itraconazole solution with a beverage (orange juice)].
Auteurs : Yoko Adachi ; Toshiya Sumikuma ; Ryogo Kagami ; Akira Nishio ; Koji Akasaka ; Hiroko Tsunemine ; Taiichi Kodaka ; Yasushi Hiramatsu ; Hiroshi TadaSource :
- [Rinsho ketsueki] The Japanese journal of clinical hematology [ 0485-1439 ] ; 2010.
English descriptors
- KwdEn :
- Administration, Oral, Adult, Aged, Aged, 80 and over, Antifungal Agents (administration & dosage), Antifungal Agents (pharmacokinetics), Beverages, Calcium Carbonate, Citrates, Citrus sinensis, Drug Combinations, Female, Hematologic Neoplasms (complications), Humans, Itraconazole (administration & dosage), Itraconazole (pharmacokinetics), Magnesium Oxide, Male, Medication Adherence, Middle Aged, Mycoses (complications), Mycoses (prevention & control), Opportunistic Infections (complications), Opportunistic Infections (prevention & control), Prospective Studies, Taste (physiology), Taste Threshold.
- MESH :
- chemical , administration & dosage : Antifungal Agents, Itraconazole.
- chemical , pharmacokinetics : Antifungal Agents, Itraconazole.
- complications : Hematologic Neoplasms, Mycoses, Opportunistic Infections.
- physiology : Taste.
- prevention & control : Mycoses, Opportunistic Infections.
- Administration, Oral, Adult, Aged, Aged, 80 and over, Beverages, Calcium Carbonate, Citrates, Citrus sinensis, Drug Combinations, Female, Humans, Magnesium Oxide, Male, Medication Adherence, Middle Aged, Prospective Studies, Taste Threshold.
Abstract
There have been some reports on the efficacy and tolerability of an oral itraconazole (ITCZ) solution as prophylaxis for fungal infection in patients with hematological malignancies. However, there are some cases where the bitter taste of oral ITCZ solution leads to an interruption of administration because the patient refuses to take this medicine. Therefore, we prospectively investigated the pharmacokinetics and promotion of treatment adherence in patients taking oral ITCZ solution mixed with a beverage. Compared with the responses of patients taking oral ITCZ solution with water, the taste of the agent was improved significantly when mixed with orange juice, although the plasma concentration of the agent did not differ between the two groups. Using this method, we can expect an improvement in treatment adherence and this method can easily be applied in clinical practice. This method is highly useful and should become common knowledge.
PubMed: 20534951
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Improvement of patient adherence by mixing oral itraconazole solution with a beverage (orange juice)].</title><author><name sortKey="Adachi, Yoko" sort="Adachi, Yoko" uniqKey="Adachi Y" first="Yoko" last="Adachi">Yoko Adachi</name><affiliation><nlm:affiliation>Department of Internal Medicine, Kobe Central Hospital of Insurance.</nlm:affiliation><wicri:noCountry code="subField">Kobe Central Hospital of Insurance</wicri:noCountry></affiliation></author><author><name sortKey="Sumikuma, Toshiya" sort="Sumikuma, Toshiya" uniqKey="Sumikuma T" first="Toshiya" last="Sumikuma">Toshiya Sumikuma</name></author><author><name sortKey="Kagami, Ryogo" sort="Kagami, Ryogo" uniqKey="Kagami R" first="Ryogo" last="Kagami">Ryogo Kagami</name></author><author><name sortKey="Nishio, Akira" sort="Nishio, Akira" uniqKey="Nishio A" first="Akira" last="Nishio">Akira Nishio</name></author><author><name sortKey="Akasaka, Koji" sort="Akasaka, Koji" uniqKey="Akasaka K" first="Koji" last="Akasaka">Koji Akasaka</name></author><author><name sortKey="Tsunemine, Hiroko" sort="Tsunemine, Hiroko" uniqKey="Tsunemine H" first="Hiroko" last="Tsunemine">Hiroko Tsunemine</name></author><author><name sortKey="Kodaka, Taiichi" sort="Kodaka, Taiichi" uniqKey="Kodaka T" first="Taiichi" last="Kodaka">Taiichi Kodaka</name></author><author><name sortKey="Hiramatsu, Yasushi" sort="Hiramatsu, Yasushi" uniqKey="Hiramatsu Y" first="Yasushi" last="Hiramatsu">Yasushi Hiramatsu</name></author><author><name sortKey="Tada, Hiroshi" sort="Tada, Hiroshi" uniqKey="Tada H" first="Hiroshi" last="Tada">Hiroshi Tada</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20534951</idno><idno type="pmid">20534951</idno><idno type="wicri:Area/PubMed/Corpus">000849</idno><idno type="wicri:Area/PubMed/Curation">000849</idno><idno type="wicri:Area/PubMed/Checkpoint">000849</idno><idno type="wicri:Area/Ncbi/Merge">000B86</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Improvement of patient adherence by mixing oral itraconazole solution with a beverage (orange juice)].</title><author><name sortKey="Adachi, Yoko" sort="Adachi, Yoko" uniqKey="Adachi Y" first="Yoko" last="Adachi">Yoko Adachi</name><affiliation><nlm:affiliation>Department of Internal Medicine, Kobe Central Hospital of Insurance.</nlm:affiliation><wicri:noCountry code="subField">Kobe Central Hospital of Insurance</wicri:noCountry></affiliation></author><author><name sortKey="Sumikuma, Toshiya" sort="Sumikuma, Toshiya" uniqKey="Sumikuma T" first="Toshiya" last="Sumikuma">Toshiya Sumikuma</name></author><author><name sortKey="Kagami, Ryogo" sort="Kagami, Ryogo" uniqKey="Kagami R" first="Ryogo" last="Kagami">Ryogo Kagami</name></author><author><name sortKey="Nishio, Akira" sort="Nishio, Akira" uniqKey="Nishio A" first="Akira" last="Nishio">Akira Nishio</name></author><author><name sortKey="Akasaka, Koji" sort="Akasaka, Koji" uniqKey="Akasaka K" first="Koji" last="Akasaka">Koji Akasaka</name></author><author><name sortKey="Tsunemine, Hiroko" sort="Tsunemine, Hiroko" uniqKey="Tsunemine H" first="Hiroko" last="Tsunemine">Hiroko Tsunemine</name></author><author><name sortKey="Kodaka, Taiichi" sort="Kodaka, Taiichi" uniqKey="Kodaka T" first="Taiichi" last="Kodaka">Taiichi Kodaka</name></author><author><name sortKey="Hiramatsu, Yasushi" sort="Hiramatsu, Yasushi" uniqKey="Hiramatsu Y" first="Yasushi" last="Hiramatsu">Yasushi Hiramatsu</name></author><author><name sortKey="Tada, Hiroshi" sort="Tada, Hiroshi" uniqKey="Tada H" first="Hiroshi" last="Tada">Hiroshi Tada</name></author></analytic><series><title level="j">[Rinsho ketsueki] The Japanese journal of clinical hematology</title><idno type="ISSN">0485-1439</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antifungal Agents (administration & dosage)</term><term>Antifungal Agents (pharmacokinetics)</term><term>Beverages</term><term>Calcium Carbonate</term><term>Citrates</term><term>Citrus sinensis</term><term>Drug Combinations</term><term>Female</term><term>Hematologic Neoplasms (complications)</term><term>Humans</term><term>Itraconazole (administration & dosage)</term><term>Itraconazole (pharmacokinetics)</term><term>Magnesium Oxide</term><term>Male</term><term>Medication Adherence</term><term>Middle Aged</term><term>Mycoses (complications)</term><term>Mycoses (prevention & control)</term><term>Opportunistic Infections (complications)</term><term>Opportunistic Infections (prevention & control)</term><term>Prospective Studies</term><term>Taste (physiology)</term><term>Taste Threshold</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antifungal Agents</term><term>Itraconazole</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Antifungal Agents</term><term>Itraconazole</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hematologic Neoplasms</term><term>Mycoses</term><term>Opportunistic Infections</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Taste</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Mycoses</term><term>Opportunistic Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Beverages</term><term>Calcium Carbonate</term><term>Citrates</term><term>Citrus sinensis</term><term>Drug Combinations</term><term>Female</term><term>Humans</term><term>Magnesium Oxide</term><term>Male</term><term>Medication Adherence</term><term>Middle Aged</term><term>Prospective Studies</term><term>Taste Threshold</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There have been some reports on the efficacy and tolerability of an oral itraconazole (ITCZ) solution as prophylaxis for fungal infection in patients with hematological malignancies. However, there are some cases where the bitter taste of oral ITCZ solution leads to an interruption of administration because the patient refuses to take this medicine. Therefore, we prospectively investigated the pharmacokinetics and promotion of treatment adherence in patients taking oral ITCZ solution mixed with a beverage. Compared with the responses of patients taking oral ITCZ solution with water, the taste of the agent was improved significantly when mixed with orange juice, although the plasma concentration of the agent did not differ between the two groups. Using this method, we can expect an improvement in treatment adherence and this method can easily be applied in clinical practice. This method is highly useful and should become common knowledge.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20534951</PMID><DateCreated><Year>2010</Year><Month>6</Month><Day>10</Day></DateCreated><DateCompleted><Year>2010</Year><Month>08</Month><Day>03</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0485-1439</ISSN><JournalIssue CitedMedium="Print"><Volume>51</Volume><Issue>5</Issue><PubDate><Year>2010</Year><Month>May</Month></PubDate></JournalIssue><Title>[Rinsho ketsueki] The Japanese journal of clinical hematology</Title><ISOAbbreviation>Rinsho Ketsueki</ISOAbbreviation></Journal><ArticleTitle>[Improvement of patient adherence by mixing oral itraconazole solution with a beverage (orange juice)].</ArticleTitle><Pagination><MedlinePgn>315-9</MedlinePgn></Pagination><Abstract><AbstractText>There have been some reports on the efficacy and tolerability of an oral itraconazole (ITCZ) solution as prophylaxis for fungal infection in patients with hematological malignancies. However, there are some cases where the bitter taste of oral ITCZ solution leads to an interruption of administration because the patient refuses to take this medicine. Therefore, we prospectively investigated the pharmacokinetics and promotion of treatment adherence in patients taking oral ITCZ solution mixed with a beverage. Compared with the responses of patients taking oral ITCZ solution with water, the taste of the agent was improved significantly when mixed with orange juice, although the plasma concentration of the agent did not differ between the two groups. Using this method, we can expect an improvement in treatment adherence and this method can easily be applied in clinical practice. This method is highly useful and should become common knowledge.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Adachi</LastName><ForeName>Yoko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Kobe Central Hospital of Insurance.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sumikuma</LastName><ForeName>Toshiya</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Kagami</LastName><ForeName>Ryogo</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Nishio</LastName><ForeName>Akira</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Akasaka</LastName><ForeName>Koji</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Tsunemine</LastName><ForeName>Hiroko</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Kodaka</LastName><ForeName>Taiichi</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Hiramatsu</LastName><ForeName>Yasushi</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Tada</LastName><ForeName>Hiroshi</ForeName><Initials>H</Initials></Author></AuthorList><Language>JPN</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>Rinsho Ketsueki</MedlineTA><NlmUniqueID>2984782R</NlmUniqueID><ISSNLinking>0485-1439</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002951">Citrates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C050615">Suby's G solution</NameOfSubstance></Chemical><Chemical><RegistryNumber>304NUG5GF4</RegistryNumber><NameOfSubstance UI="D017964">Itraconazole</NameOfSubstance></Chemical><Chemical><RegistryNumber>3A3U0GI71G</RegistryNumber><NameOfSubstance UI="D008277">Magnesium Oxide</NameOfSubstance></Chemical><Chemical><RegistryNumber>H0G9379FGK</RegistryNumber><NameOfSubstance UI="D002119">Calcium Carbonate</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000935" MajorTopicYN="N">Antifungal Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001628" MajorTopicYN="Y">Beverages</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002119" MajorTopicYN="N">Calcium Carbonate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002951" MajorTopicYN="N">Citrates</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="Y">Citrus sinensis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004338" MajorTopicYN="N">Drug Combinations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019337" MajorTopicYN="N">Hematologic Neoplasms</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017964" MajorTopicYN="N">Itraconazole</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008277" MajorTopicYN="N">Magnesium Oxide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055118" MajorTopicYN="Y">Medication Adherence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009181" MajorTopicYN="N">Mycoses</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009894" MajorTopicYN="N">Opportunistic Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013649" MajorTopicYN="N">Taste</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013652" MajorTopicYN="N">Taste Threshold</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>6</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>6</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20534951</ArticleId><ArticleId IdType="pii">JST.JSTAGE/rinketsu/51.315</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Adachi, Yoko" sort="Adachi, Yoko" uniqKey="Adachi Y" first="Yoko" last="Adachi">Yoko Adachi</name><name sortKey="Akasaka, Koji" sort="Akasaka, Koji" uniqKey="Akasaka K" first="Koji" last="Akasaka">Koji Akasaka</name><name sortKey="Hiramatsu, Yasushi" sort="Hiramatsu, Yasushi" uniqKey="Hiramatsu Y" first="Yasushi" last="Hiramatsu">Yasushi Hiramatsu</name><name sortKey="Kagami, Ryogo" sort="Kagami, Ryogo" uniqKey="Kagami R" first="Ryogo" last="Kagami">Ryogo Kagami</name><name sortKey="Kodaka, Taiichi" sort="Kodaka, Taiichi" uniqKey="Kodaka T" first="Taiichi" last="Kodaka">Taiichi Kodaka</name><name sortKey="Nishio, Akira" sort="Nishio, Akira" uniqKey="Nishio A" first="Akira" last="Nishio">Akira Nishio</name><name sortKey="Sumikuma, Toshiya" sort="Sumikuma, Toshiya" uniqKey="Sumikuma T" first="Toshiya" last="Sumikuma">Toshiya Sumikuma</name><name sortKey="Tada, Hiroshi" sort="Tada, Hiroshi" uniqKey="Tada H" first="Hiroshi" last="Tada">Hiroshi Tada</name><name sortKey="Tsunemine, Hiroko" sort="Tsunemine, Hiroko" uniqKey="Tsunemine H" first="Hiroko" last="Tsunemine">Hiroko Tsunemine</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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