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Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.

Identifieur interne : 002B90 ( Main/Exploration ); précédent : 002B89; suivant : 002B91

Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.

Auteurs : Run Tian [Japon] ; Noriko Koyabu ; Hitomi Takanaga ; Hirotami Matsuo ; Hisakazu Ohtani ; Yasufumi Sawada

Source :

Pharmaceutical research [ 0724-8741 ] ; 2002.

RBID : pubmed:12134950

English descriptors

KwdEn :
- Animals, Beverages, Citrus paradisi (chemistry), Citrus sinensis (chemistry), In Vitro Techniques, Intestine, Small (metabolism), Male, P-Glycoprotein (metabolism), Plant Extracts (pharmacology), Rats, Rhodamine 123, Substrate Specificity (physiology).
MESH :
- chemical , metabolism : P-Glycoprotein.
- chemistry : Citrus paradisi, Citrus sinensis.
- metabolism : Intestine, Small.
- chemical , pharmacology : Plant Extracts.
- physiology : Substrate Specificity.
- Animals, Beverages, In Vitro Techniques, Male, Rats, Rhodamine 123.

Abstract

The aim of this study is to investigate the effects of 50% ethyl acetate extracts of grapefruit juice (GFJ) and orange juice (OJ) on the transport activity of P-glycoprotein (P-gp) in the rat small intestine.

PubMed: 12134950

Affiliations:

Le document en format XML

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<author><name sortKey="Tian, Run" sort="Tian, Run" uniqKey="Tian R" first="Run" last="Tian">Run Tian</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka</wicri:regionArea>
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<author><name sortKey="Koyabu, Noriko" sort="Koyabu, Noriko" uniqKey="Koyabu N" first="Noriko" last="Koyabu">Noriko Koyabu</name>
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<author><name sortKey="Takanaga, Hitomi" sort="Takanaga, Hitomi" uniqKey="Takanaga H" first="Hitomi" last="Takanaga">Hitomi Takanaga</name>
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<author><name sortKey="Matsuo, Hirotami" sort="Matsuo, Hirotami" uniqKey="Matsuo H" first="Hirotami" last="Matsuo">Hirotami Matsuo</name>
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<author><name sortKey="Ohtani, Hisakazu" sort="Ohtani, Hisakazu" uniqKey="Ohtani H" first="Hisakazu" last="Ohtani">Hisakazu Ohtani</name>
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<author><name sortKey="Sawada, Yasufumi" sort="Sawada, Yasufumi" uniqKey="Sawada Y" first="Yasufumi" last="Sawada">Yasufumi Sawada</name>
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<affiliation wicri:level="4"><nlm:affiliation>Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.</nlm:affiliation>
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<author><name sortKey="Koyabu, Noriko" sort="Koyabu, Noriko" uniqKey="Koyabu N" first="Noriko" last="Koyabu">Noriko Koyabu</name>
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<author><name sortKey="Takanaga, Hitomi" sort="Takanaga, Hitomi" uniqKey="Takanaga H" first="Hitomi" last="Takanaga">Hitomi Takanaga</name>
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<author><name sortKey="Matsuo, Hirotami" sort="Matsuo, Hirotami" uniqKey="Matsuo H" first="Hirotami" last="Matsuo">Hirotami Matsuo</name>
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<author><name sortKey="Ohtani, Hisakazu" sort="Ohtani, Hisakazu" uniqKey="Ohtani H" first="Hisakazu" last="Ohtani">Hisakazu Ohtani</name>
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<author><name sortKey="Sawada, Yasufumi" sort="Sawada, Yasufumi" uniqKey="Sawada Y" first="Yasufumi" last="Sawada">Yasufumi Sawada</name>
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<series><title level="j">Pharmaceutical research</title>
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<imprint><date when="2002" type="published">2002</date>
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<term>Citrus sinensis (chemistry)</term>
<term>In Vitro Techniques</term>
<term>Intestine, Small (metabolism)</term>
<term>Male</term>
<term>P-Glycoprotein (metabolism)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Rats</term>
<term>Rhodamine 123</term>
<term>Substrate Specificity (physiology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>P-Glycoprotein</term>
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<front><div type="abstract" xml:lang="en">The aim of this study is to investigate the effects of 50% ethyl acetate extracts of grapefruit juice (GFJ) and orange juice (OJ) on the transport activity of P-glycoprotein (P-gp) in the rat small intestine.</div>
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<affiliations><list><country><li>Japon</li>
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<region><li>Kyūshū</li>
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<settlement><li>Fukuoka</li>
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<orgName><li>Université de Kyūshū</li>
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<tree><noCountry><name sortKey="Koyabu, Noriko" sort="Koyabu, Noriko" uniqKey="Koyabu N" first="Noriko" last="Koyabu">Noriko Koyabu</name>
<name sortKey="Matsuo, Hirotami" sort="Matsuo, Hirotami" uniqKey="Matsuo H" first="Hirotami" last="Matsuo">Hirotami Matsuo</name>
<name sortKey="Ohtani, Hisakazu" sort="Ohtani, Hisakazu" uniqKey="Ohtani H" first="Hisakazu" last="Ohtani">Hisakazu Ohtani</name>
<name sortKey="Sawada, Yasufumi" sort="Sawada, Yasufumi" uniqKey="Sawada Y" first="Yasufumi" last="Sawada">Yasufumi Sawada</name>
<name sortKey="Takanaga, Hitomi" sort="Takanaga, Hitomi" uniqKey="Takanaga H" first="Hitomi" last="Takanaga">Hitomi Takanaga</name>
</noCountry>
<country name="Japon"><region name="Kyūshū"><name sortKey="Tian, Run" sort="Tian, Run" uniqKey="Tian R" first="Run" last="Tian">Run Tian</name>
</region>
</country>
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Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.

Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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