Anti-hyperglycemic activity of Centella asiatica is partly mediated by carbohydrase inhibition and glucose-fiber binding
Identifieur interne : 000C04 ( Main/Exploration ); précédent : 000C03; suivant : 000C05Anti-hyperglycemic activity of Centella asiatica is partly mediated by carbohydrase inhibition and glucose-fiber binding
Auteurs : Ashraf Ul Kabir [Bangladesh] ; Mehdi Bin Samad [Bangladesh] ; Ninadh Malrina D Osta [Bangladesh] ; Farjana Akhter [Bangladesh] ; Arif Ahmed [Bangladesh] ; Jma Hannan [Bangladesh]Source :
- BMC Complementary and Alternative Medicine [ 1472-6882 ] ; 2014.
Abstract
For primary evaluation of anti-hyperglycemic activity, we measured Fasting Blood Glucose and performed Glucose Tolerance Test, in type 2 diabetic rats. To further study the pancreatic effect and glucose utilization, plasma insulin concentration, insulin secreted from isolated rat islets and liver glycogen were assayed. Effect on carbohydrate break down was assayed using intestinal disaccharidase enzyme, α-amylase inhibition assays and Six-Segment study of the GI tract. Effect of
A combination of in-vitro, in-vivo and in-situ tests confirmed the anti-hyperglycemic activity of
Url:
DOI: 10.1186/1472-6882-14-31
PubMed: 24438380
PubMed Central: 3900709
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anti-hyperglycemic activity of <italic>Centella asiatica</italic> is partly mediated by carbohydrase inhibition and glucose-fiber binding</title><author><name sortKey="Kabir, Ashraf Ul" sort="Kabir, Ashraf Ul" uniqKey="Kabir A" first="Ashraf Ul" last="Kabir">Ashraf Ul Kabir</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacy, North South University, Dhaka, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Pharmacy, North South University, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author><author><name sortKey="Samad, Mehdi Bin" sort="Samad, Mehdi Bin" uniqKey="Samad M" first="Mehdi Bin" last="Samad">Mehdi Bin Samad</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacy, North South University, Dhaka, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Pharmacy, North South University, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author><author><name sortKey="D Osta, Ninadh Malrina" sort="D Osta, Ninadh Malrina" uniqKey="D Osta N" first="Ninadh Malrina" last="D Osta">Ninadh Malrina D Osta</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacy, North South University, Dhaka, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Pharmacy, North South University, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author><author><name sortKey="Akhter, Farjana" sort="Akhter, Farjana" uniqKey="Akhter F" first="Farjana" last="Akhter">Farjana Akhter</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacy, North South University, Dhaka, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Pharmacy, North South University, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author><author><name sortKey="Ahmed, Arif" sort="Ahmed, Arif" uniqKey="Ahmed A" first="Arif" last="Ahmed">Arif Ahmed</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacy, North South University, Dhaka, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Pharmacy, North South University, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author><author><name sortKey="Hannan, Jma" sort="Hannan, Jma" uniqKey="Hannan J" first="Jma" last="Hannan">Jma Hannan</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacy, North South University, Dhaka, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Pharmacy, North South University, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24438380</idno><idno type="pmc">3900709</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900709</idno><idno type="RBID">PMC:3900709</idno><idno type="doi">10.1186/1472-6882-14-31</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000A97</idno><idno type="wicri:Area/Pmc/Curation">000A96</idno><idno type="wicri:Area/Pmc/Checkpoint">000913</idno><idno type="wicri:Area/Ncbi/Merge">001561</idno><idno type="wicri:Area/Ncbi/Curation">001561</idno><idno type="wicri:Area/Ncbi/Checkpoint">001561</idno><idno type="wicri:Area/Main/Merge">000C07</idno><idno type="wicri:Area/Main/Curation">000C04</idno><idno type="wicri:Area/Main/Exploration">000C04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Anti-hyperglycemic activity of <italic>Centella asiatica</italic> is partly mediated by carbohydrase inhibition and glucose-fiber binding</title><author><name sortKey="Kabir, Ashraf Ul" sort="Kabir, Ashraf Ul" uniqKey="Kabir A" first="Ashraf Ul" last="Kabir">Ashraf Ul Kabir</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacy, North South University, Dhaka, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Pharmacy, North South University, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author><author><name sortKey="Samad, Mehdi Bin" sort="Samad, Mehdi Bin" uniqKey="Samad M" first="Mehdi Bin" last="Samad">Mehdi Bin Samad</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacy, North South University, Dhaka, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Pharmacy, North South University, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author><author><name sortKey="D Osta, Ninadh Malrina" sort="D Osta, Ninadh Malrina" uniqKey="D Osta N" first="Ninadh Malrina" last="D Osta">Ninadh Malrina D Osta</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacy, North South University, Dhaka, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Pharmacy, North South University, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author><author><name sortKey="Akhter, Farjana" sort="Akhter, Farjana" uniqKey="Akhter F" first="Farjana" last="Akhter">Farjana Akhter</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacy, North South University, Dhaka, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Pharmacy, North South University, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author><author><name sortKey="Ahmed, Arif" sort="Ahmed, Arif" uniqKey="Ahmed A" first="Arif" last="Ahmed">Arif Ahmed</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacy, North South University, Dhaka, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Pharmacy, North South University, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author><author><name sortKey="Hannan, Jma" sort="Hannan, Jma" uniqKey="Hannan J" first="Jma" last="Hannan">Jma Hannan</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacy, North South University, Dhaka, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Pharmacy, North South University, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Complementary and Alternative Medicine</title><idno type="eISSN">1472-6882</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p><italic>Centella asiatica</italic> (<italic>C. asiatica</italic>) was previously reported to have anti-hyperglycemic effects in animal diabetic model rats. However, its activity on organ and tissue level remains unstudied. Our study aims at exploring the possible effects, <italic>C. asiatica</italic> extract and insoluble fiber has on carbohydrate absorption, insulin secretion, insulin sensitivity and glucose utilization.</p></sec><sec><title>Methods</title><p>For primary evaluation of anti-hyperglycemic activity, we measured Fasting Blood Glucose and performed Glucose Tolerance Test, in type 2 diabetic rats. To further study the pancreatic effect and glucose utilization, plasma insulin concentration, insulin secreted from isolated rat islets and liver glycogen were assayed. Effect on carbohydrate break down was assayed using intestinal disaccharidase enzyme, α-amylase inhibition assays and Six-Segment study of the GI tract. Effect of <italic>C. asiatica</italic> on glucose absorption was studied by an in-situ, perfused, intestinal model in rats and by glucose-fiber binding assay. Gastrointestinal motility was seen by a BaSO<sub>4</sub> milk traverse test. Additionally, a complete lipid profile assay, after a chronic study, was conducted.</p></sec><sec><title>Results</title><p><italic>C. asiatica</italic> showed no significant change in insulin secretion in-vivo and in isolated rat islets. Additionally, no effect of the extract was seen on liver glycogen deposition. Retarded glucose absorption was seen in the in-situ perfused rat intestinal model at a dose. The extract was also found to inhibit action of both intestinal disaccharidase and α-amylase. This was confirmed, yet again, via the Six Segment study, where sucrose digestion was found to be inhibited throughout the length of the GI Tract. Significant glucose-fiber binding was demonstrated in the in-vitro models. During the chronic study, body mass of <italic>C. asiatica</italic> treated Type 2 diabetic rats returned to normal and their polydipsic and polyphagic conditions were also improved. Chronic treatment of <italic>C. asiatica</italic> also improved subject’s lipid profile.</p></sec><sec><title>Conclusion</title><p>A combination of in-vitro, in-vivo and in-situ tests confirmed the anti-hyperglycemic activity of <italic>C. asiatica</italic> and its tissue level mechanism. 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Edwards</name></author><author><name sortKey="Johnson, I" uniqKey="Johnson I">I Johnson</name></author><author><name sortKey="Read, N" uniqKey="Read N">N Read</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jamil, Ss" uniqKey="Jamil S">SS Jamil</name></author><author><name sortKey="Nizami, Q" uniqKey="Nizami Q">Q Nizami</name></author><author><name sortKey="Salam, M" uniqKey="Salam M">M Salam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burkitt, D" uniqKey="Burkitt D">D Burkitt</name></author><author><name sortKey="Walker, A" uniqKey="Walker A">A Walker</name></author><author><name sortKey="Painter, Ns" uniqKey="Painter N">NS Painter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holgate, A" uniqKey="Holgate A">A Holgate</name></author><author><name sortKey="Read, N" uniqKey="Read N">N Read</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reynell, P" uniqKey="Reynell P">P Reynell</name></author><author><name sortKey="Spray, G" uniqKey="Spray G">G Spray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crane, Rk" uniqKey="Crane R">RK Crane</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Bangladesh</li></country></list><tree><country name="Bangladesh"><noRegion><name sortKey="Kabir, Ashraf Ul" sort="Kabir, Ashraf Ul" uniqKey="Kabir A" first="Ashraf Ul" last="Kabir">Ashraf Ul Kabir</name></noRegion><name sortKey="Ahmed, Arif" sort="Ahmed, Arif" uniqKey="Ahmed A" first="Arif" last="Ahmed">Arif Ahmed</name><name sortKey="Akhter, Farjana" sort="Akhter, Farjana" uniqKey="Akhter F" first="Farjana" last="Akhter">Farjana Akhter</name><name sortKey="D Osta, Ninadh Malrina" sort="D Osta, Ninadh Malrina" uniqKey="D Osta N" first="Ninadh Malrina" last="D Osta">Ninadh Malrina D Osta</name><name sortKey="Hannan, Jma" sort="Hannan, Jma" uniqKey="Hannan J" first="Jma" last="Hannan">Jma Hannan</name><name sortKey="Samad, Mehdi Bin" sort="Samad, Mehdi Bin" uniqKey="Samad M" first="Mehdi Bin" last="Samad">Mehdi Bin Samad</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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