Adherence challenges with drugs for pre-exposure prophylaxis to prevent HIV infection.
Identifieur interne : 001647 ( PubMed/Corpus ); précédent : 001646; suivant : 001648Adherence challenges with drugs for pre-exposure prophylaxis to prevent HIV infection.
Auteurs : Tanuja N. Gengiah ; Atika Moosa ; Anushka Naidoo ; Leila E. MansoorSource :
- International journal of clinical pharmacy [ 2210-7711 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Anti-HIV Agents.
- chemical , pharmacology : Anti-HIV Agents.
- chemical , therapeutic use : Anti-HIV Agents.
- drug therapy : HIV Infections.
- prevention & control : HIV Infections.
- psychology : HIV Infections, Medication Adherence.
- Administration, Oral, Administration, Topical, Humans.
Abstract
There are 34 million people living with human immunodeficiency virus (HIV) worldwide and each year this number increases. Until a vaccine is discovered, the prevention of new HIV infections remains an urgent priority. Several trials studying the use of oral and topical agents for the prevention of HIV infection have already been completed. Adherence has proved to be a major challenge in achieving product efficacy.
DOI: 10.1007/s11096-013-9861-1
PubMed: 24129582
Links to Exploration step
pubmed:24129582Le document en format XML
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<author><name sortKey="Moosa, Atika" sort="Moosa, Atika" uniqKey="Moosa A" first="Atika" last="Moosa">Atika Moosa</name>
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<author><name sortKey="Naidoo, Anushka" sort="Naidoo, Anushka" uniqKey="Naidoo A" first="Anushka" last="Naidoo">Anushka Naidoo</name>
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<author><name sortKey="Mansoor, Leila E" sort="Mansoor, Leila E" uniqKey="Mansoor L" first="Leila E" last="Mansoor">Leila E. Mansoor</name>
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<affiliation><nlm:affiliation>Centre for the AIDS Programme of Research in South Africa (CAPRISA), 2nd Floor, K-RITH Tower Building, University of KwaZulu-Natal, 719 Umbilo Road, Durban, 4001, South Africa, gengiaht1@ukzn.ac.za.</nlm:affiliation>
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<author><name sortKey="Naidoo, Anushka" sort="Naidoo, Anushka" uniqKey="Naidoo A" first="Anushka" last="Naidoo">Anushka Naidoo</name>
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<author><name sortKey="Mansoor, Leila E" sort="Mansoor, Leila E" uniqKey="Mansoor L" first="Leila E" last="Mansoor">Leila E. Mansoor</name>
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<series><title level="j">International journal of clinical pharmacy</title>
<idno type="eISSN">2210-7711</idno>
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<term>Anti-HIV Agents (therapeutic use)</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (prevention & control)</term>
<term>HIV Infections (psychology)</term>
<term>Humans</term>
<term>Medication Adherence (psychology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-HIV Agents</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-HIV Agents</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>HIV Infections</term>
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<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>HIV Infections</term>
<term>Medication Adherence</term>
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<front><div type="abstract" xml:lang="en">There are 34 million people living with human immunodeficiency virus (HIV) worldwide and each year this number increases. Until a vaccine is discovered, the prevention of new HIV infections remains an urgent priority. Several trials studying the use of oral and topical agents for the prevention of HIV infection have already been completed. Adherence has proved to be a major challenge in achieving product efficacy.</div>
</front>
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<DateCreated><Year>2014</Year>
<Month>01</Month>
<Day>09</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>12</Month>
<Day>18</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2210-7711</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>36</Volume>
<Issue>1</Issue>
<PubDate><Year>2014</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>International journal of clinical pharmacy</Title>
<ISOAbbreviation>Int J Clin Pharm</ISOAbbreviation>
</Journal>
<ArticleTitle>Adherence challenges with drugs for pre-exposure prophylaxis to prevent HIV infection.</ArticleTitle>
<Pagination><MedlinePgn>70-85</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s11096-013-9861-1</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">There are 34 million people living with human immunodeficiency virus (HIV) worldwide and each year this number increases. Until a vaccine is discovered, the prevention of new HIV infections remains an urgent priority. Several trials studying the use of oral and topical agents for the prevention of HIV infection have already been completed. Adherence has proved to be a major challenge in achieving product efficacy.</AbstractText>
<AbstractText Label="AIM OF THE REVIEW" NlmCategory="OBJECTIVE">To provide the clinical pharmacist with an understanding of the oral pre-exposure prophylaxis (PrEP) and topical microbicide product pipeline whilst emphasizing the critical importance of adherence to these drugs to avert HIV infection.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">PubMed/Medline and the web-based clinical trials registry (ClinTrials.gov) were searched using appropriate key words. For the time period 1992-2013--all phase II and phase III safety and effectiveness studies--testing agents for prevention of HIV infection were included in the review. Efficacy estimates, adherence estimates and reported challenges with adherence were extracted.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Twenty-four phase II and III clinical trials were found during review. Of these, 20 trials have been completed, and six trials show effectiveness in preventing HIV infection. The majority of the successful trials were to oral PrEP and to date only one microbicide trial of a vaginal antiretroviral microbicide gel has showed effectiveness. Adherence to study product played a major role in trial outcomes and there are several reasons for non-adherence. These include high on-trial pregnancy rates, low trial retention rates, low participant perception of risk, participant characteristics such as age <25 years, single status, migratory partners and trial fatigue. Study product characteristics such as dosage form, dosing interval, as well as associated adverse events may also influence adherence.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Moderate to high adherence is critical to demonstrate efficacy of drugs for HIV prevention. For topical agents, intermittent use associated with coitus is more effective than daily use, particularly if sex is infrequent or partners migrant. For oral agents, daily use is effective but the motivation to use the drug and high risk perception is important. In serodiscordant couples, early initiation of highly active antiretroviral therapy in the infected partner affords almost complete protection to the negative partner. Drugs need to be tailored to the population at risk and availability of multiple drug options are important.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gengiah</LastName>
<ForeName>Tanuja N</ForeName>
<Initials>TN</Initials>
<AffiliationInfo><Affiliation>Centre for the AIDS Programme of Research in South Africa (CAPRISA), 2nd Floor, K-RITH Tower Building, University of KwaZulu-Natal, 719 Umbilo Road, Durban, 4001, South Africa, gengiaht1@ukzn.ac.za.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moosa</LastName>
<ForeName>Atika</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Naidoo</LastName>
<ForeName>Anushka</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Mansoor</LastName>
<ForeName>Leila E</ForeName>
<Initials>LE</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>D43 TW000231</GrantID>
<Acronym>TW</Acronym>
<Agency>FIC NIH HHS</Agency>
<Country>United States</Country>
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<Grant><GrantID>U19 AI051794</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
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