Comparing the effectiveness of efavirenz and nevirapine for first-line antiretroviral therapy in a South African multicentre cohort.
Identifieur interne : 001646 ( PubMed/Corpus ); précédent : 001645; suivant : 001647Comparing the effectiveness of efavirenz and nevirapine for first-line antiretroviral therapy in a South African multicentre cohort.
Auteurs : Peter Bock ; Geoffrey Fatti ; Ashraf GrimwoodSource :
- International health [ 1876-3405 ] ; 2013.
English descriptors
- KwdEn :
- Adolescent, Adult, Anti-HIV Agents (pharmacology), Anti-HIV Agents (therapeutic use), Benzoxazines (adverse effects), Benzoxazines (pharmacology), Benzoxazines (therapeutic use), CD4 Lymphocyte Count, Cohort Studies, Female, HIV Infections (drug therapy), HIV Infections (mortality), HIV Infections (virology), Humans, Male, Middle Aged, Nevirapine (pharmacology), Nevirapine (therapeutic use), Pregnancy, Proportional Hazards Models, Reverse Transcriptase Inhibitors (adverse effects), Reverse Transcriptase Inhibitors (pharmacology), Reverse Transcriptase Inhibitors (therapeutic use), South Africa, Treatment Outcome, Viral Load (drug effects), Young Adult.
- MESH :
- chemical , adverse effects : Benzoxazines, Reverse Transcriptase Inhibitors.
- chemical , pharmacology : Anti-HIV Agents, Benzoxazines, Nevirapine, Reverse Transcriptase Inhibitors.
- chemical , therapeutic use : Anti-HIV Agents, Benzoxazines, Nevirapine, Reverse Transcriptase Inhibitors.
- geographic : South Africa.
- drug effects : Viral Load.
- drug therapy : HIV Infections.
- mortality : HIV Infections.
- virology : HIV Infections.
- Adolescent, Adult, CD4 Lymphocyte Count, Cohort Studies, Female, Humans, Male, Middle Aged, Pregnancy, Proportional Hazards Models, Treatment Outcome, Young Adult.
Abstract
Current WHO guidelines for developing countries recommend efavirenz (EFV) and nevirapine (NVP) for first-line antiretroviral treatment (ART). This paper compares the effectiveness of EFV and NVP among ART-naive patients initiating treatment at 56 public health facilities in South Africa between January 2004 and December 2007.
DOI: 10.1093/inthealth/iht002
PubMed: 24030113
Links to Exploration step
pubmed:24030113Le document en format XML
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<author><name sortKey="Bock, Peter" sort="Bock, Peter" uniqKey="Bock P" first="Peter" last="Bock">Peter Bock</name>
<affiliation><nlm:affiliation>Kheth'Impilo, Green Square, 37 Hares Crescent, Woodstock, 7925, Cape Town, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fatti, Geoffrey" sort="Fatti, Geoffrey" uniqKey="Fatti G" first="Geoffrey" last="Fatti">Geoffrey Fatti</name>
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<author><name sortKey="Grimwood, Ashraf" sort="Grimwood, Ashraf" uniqKey="Grimwood A" first="Ashraf" last="Grimwood">Ashraf Grimwood</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Comparing the effectiveness of efavirenz and nevirapine for first-line antiretroviral therapy in a South African multicentre cohort.</title>
<author><name sortKey="Bock, Peter" sort="Bock, Peter" uniqKey="Bock P" first="Peter" last="Bock">Peter Bock</name>
<affiliation><nlm:affiliation>Kheth'Impilo, Green Square, 37 Hares Crescent, Woodstock, 7925, Cape Town, South Africa.</nlm:affiliation>
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<author><name sortKey="Fatti, Geoffrey" sort="Fatti, Geoffrey" uniqKey="Fatti G" first="Geoffrey" last="Fatti">Geoffrey Fatti</name>
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<series><title level="j">International health</title>
<idno type="eISSN">1876-3405</idno>
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<term>Adult</term>
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<term>Anti-HIV Agents (therapeutic use)</term>
<term>Benzoxazines (adverse effects)</term>
<term>Benzoxazines (pharmacology)</term>
<term>Benzoxazines (therapeutic use)</term>
<term>CD4 Lymphocyte Count</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (mortality)</term>
<term>HIV Infections (virology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nevirapine (pharmacology)</term>
<term>Nevirapine (therapeutic use)</term>
<term>Pregnancy</term>
<term>Proportional Hazards Models</term>
<term>Reverse Transcriptase Inhibitors (adverse effects)</term>
<term>Reverse Transcriptase Inhibitors (pharmacology)</term>
<term>Reverse Transcriptase Inhibitors (therapeutic use)</term>
<term>South Africa</term>
<term>Treatment Outcome</term>
<term>Viral Load (drug effects)</term>
<term>Young Adult</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Benzoxazines</term>
<term>Reverse Transcriptase Inhibitors</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-HIV Agents</term>
<term>Benzoxazines</term>
<term>Nevirapine</term>
<term>Reverse Transcriptase Inhibitors</term>
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<term>Benzoxazines</term>
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<term>Reverse Transcriptase Inhibitors</term>
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<keywords scheme="MESH" type="geographic" xml:lang="en"><term>South Africa</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Viral Load</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>CD4 Lymphocyte Count</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">Current WHO guidelines for developing countries recommend efavirenz (EFV) and nevirapine (NVP) for first-line antiretroviral treatment (ART). This paper compares the effectiveness of EFV and NVP among ART-naive patients initiating treatment at 56 public health facilities in South Africa between January 2004 and December 2007.</div>
</front>
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<DateCreated><Year>2013</Year>
<Month>09</Month>
<Day>13</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>08</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>05</Month>
<Day>11</Day>
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<JournalIssue CitedMedium="Internet"><Volume>5</Volume>
<Issue>2</Issue>
<PubDate><Year>2013</Year>
<Month>Jun</Month>
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<Title>International health</Title>
<ISOAbbreviation>Int Health</ISOAbbreviation>
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<ArticleTitle>Comparing the effectiveness of efavirenz and nevirapine for first-line antiretroviral therapy in a South African multicentre cohort.</ArticleTitle>
<Pagination><MedlinePgn>132-8</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/inthealth/iht002</ELocationID>
<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Current WHO guidelines for developing countries recommend efavirenz (EFV) and nevirapine (NVP) for first-line antiretroviral treatment (ART). This paper compares the effectiveness of EFV and NVP among ART-naive patients initiating treatment at 56 public health facilities in South Africa between January 2004 and December 2007.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Participants were assigned to the EFV or NVP cohorts depending on their baseline ART regimen. Mortality, viral load suppression after 6 months and ART regimen change were compared between the cohorts using Cox proportional hazards models and logistic regression.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">At initiation, 19 441 (71.1%) patients started EFV and 7909 (28.9%) started NVP treatment. The median follow-up period was 9.5 months (IQR 4.6-17.7). After adjustment, mortality was similar in the two cohorts, (adjusted HR = 1.07, 95% CI 0.89-1.28). Viral load suppression at 6 months was higher in the EFV cohort overall (adjusted odds ratio [AOR] = 1.29, 95% CI 1.05-1.59) and in women aged 16-40 years (AOR = 1.35, 95% CI 1.11-1.63) and women with CD4 counts <25 cells/µL (AOR = 1.95, 95% CI 1.01-3.76). Patients starting on EFV were 47% less likely to change regimen (AOR = 0.53, 95% CI 0.48-0.59).</AbstractText>
<AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">These findings suggest the superior effectiveness of EFV for first-line ART compared with NVP and should be considered during development of future ART guidelines for high-burden regions.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bock</LastName>
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<AffiliationInfo><Affiliation>Kheth'Impilo, Green Square, 37 Hares Crescent, Woodstock, 7925, Cape Town, South Africa.</Affiliation>
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<Author ValidYN="Y"><LastName>Grimwood</LastName>
<ForeName>Ashraf</ForeName>
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<Language>eng</Language>
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<PublicationType UI="D003160">Comparative Study</PublicationType>
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<MedlineJournalInfo><Country>England</Country>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
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<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D019829" MajorTopicYN="N">Nevirapine</DescriptorName>
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