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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Maternal risk factors for HIV infection in infants in northeastern Brazil</title><author><name sortKey="De Lemos, Ligia M D" sort="De Lemos, Ligia M D" uniqKey="De Lemos L" first="Lígia M. D." last="De Lemos">Lígia M. D. De Lemos</name><affiliation><nlm:aff id="A1">Department of Nursing, Federal University of Sergipe, Aracaju, Sergipe, Brazil</nlm:aff></affiliation></author><author><name sortKey="Lippi, Joseph" sort="Lippi, Joseph" uniqKey="Lippi J" first="Joseph" last="Lippi">Joseph Lippi</name><affiliation><nlm:aff id="A2">Global Health Sciences, University of California, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="Rutherford, George W" sort="Rutherford, George W" uniqKey="Rutherford G" first="George W." last="Rutherford">George W. Rutherford</name><affiliation><nlm:aff id="A2">Global Health Sciences, University of California, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="Duarte, Gabriella S" sort="Duarte, Gabriella S" uniqKey="Duarte G" first="Gabriella S." last="Duarte">Gabriella S. Duarte</name><affiliation><nlm:aff id="A1">Department of Nursing, Federal University of Sergipe, Aracaju, Sergipe, Brazil</nlm:aff></affiliation></author><author><name sortKey="Martins, Nagyla G R" sort="Martins, Nagyla G R" uniqKey="Martins N" first="Nágyla G. R." last="Martins">Nágyla G. R. Martins</name><affiliation><nlm:aff id="A1">Department of Nursing, Federal University of Sergipe, Aracaju, Sergipe, Brazil</nlm:aff></affiliation></author><author><name sortKey="Santos, Victor S" sort="Santos, Victor S" uniqKey="Santos V" first="Victor S." last="Santos">Victor S. Santos</name><affiliation><nlm:aff id="A1">Department of Nursing, Federal University of Sergipe, Aracaju, Sergipe, Brazil</nlm:aff></affiliation></author><author><name sortKey="Gurgel, Ricardo Q" sort="Gurgel, Ricardo Q" uniqKey="Gurgel R" first="Ricardo Q." last="Gurgel">Ricardo Q. Gurgel</name><affiliation><nlm:aff id="A3">Department of Medicine – Pediatrics, Federal University of Sergipe, Aracaju, Sergipe, Brazil</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23791426</idno><idno type="pmc">5463571</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463571</idno><idno type="RBID">PMC:5463571</idno><idno type="doi">10.1016/j.ijid.2013.04.015</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001F19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Maternal risk factors for HIV infection in infants in northeastern Brazil</title><author><name sortKey="De Lemos, Ligia M D" sort="De Lemos, Ligia M D" uniqKey="De Lemos L" first="Lígia M. D." last="De Lemos">Lígia M. D. De Lemos</name><affiliation><nlm:aff id="A1">Department of Nursing, Federal University of Sergipe, Aracaju, Sergipe, Brazil</nlm:aff></affiliation></author><author><name sortKey="Lippi, Joseph" sort="Lippi, Joseph" uniqKey="Lippi J" first="Joseph" last="Lippi">Joseph Lippi</name><affiliation><nlm:aff id="A2">Global Health Sciences, University of California, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="Rutherford, George W" sort="Rutherford, George W" uniqKey="Rutherford G" first="George W." last="Rutherford">George W. Rutherford</name><affiliation><nlm:aff id="A2">Global Health Sciences, University of California, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="Duarte, Gabriella S" sort="Duarte, Gabriella S" uniqKey="Duarte G" first="Gabriella S." last="Duarte">Gabriella S. Duarte</name><affiliation><nlm:aff id="A1">Department of Nursing, Federal University of Sergipe, Aracaju, Sergipe, Brazil</nlm:aff></affiliation></author><author><name sortKey="Martins, Nagyla G R" sort="Martins, Nagyla G R" uniqKey="Martins N" first="Nágyla G. R." last="Martins">Nágyla G. R. Martins</name><affiliation><nlm:aff id="A1">Department of Nursing, Federal University of Sergipe, Aracaju, Sergipe, Brazil</nlm:aff></affiliation></author><author><name sortKey="Santos, Victor S" sort="Santos, Victor S" uniqKey="Santos V" first="Victor S." last="Santos">Victor S. Santos</name><affiliation><nlm:aff id="A1">Department of Nursing, Federal University of Sergipe, Aracaju, Sergipe, Brazil</nlm:aff></affiliation></author><author><name sortKey="Gurgel, Ricardo Q" sort="Gurgel, Ricardo Q" uniqKey="Gurgel R" first="Ricardo Q." last="Gurgel">Ricardo Q. Gurgel</name><affiliation><nlm:aff id="A3">Department of Medicine – Pediatrics, Federal University of Sergipe, Aracaju, Sergipe, Brazil</nlm:aff></affiliation></author></analytic><series><title level="j">International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><sec id="S1"><title>Introduction</title><p id="P1">While the rate of vertically transmitted HIV infection has fallen in most regions of Brazil, there have been no similar decreases in northern and northeastern Brazil.</p></sec><sec id="S2"><title>Objective</title><p id="P2">The objective of this study was to evaluate the risk factors associated with vertical transmission in the state of Sergipe in northeastern Brazil.</p></sec><sec id="S3"><title>Methods</title><p id="P3">This was a retrospective cohort study. We recorded clinic and registry data for all HIV-infected pregnant women and exposed children diagnosed in Sergipe from 1990 to 2011.</p></sec><sec id="S4"><title>Results</title><p id="P4">We identified 538 deliveries and 561 HIV-exposed infants (23 sets of twins). One hundred one (18.9%) infants were HIV-infected. In the multivariate analysis, infant antiretroviral prophylaxis was a significant protective factor (adjusted odds ratio (aOR) 0.07, 95% confidence interval (CI) 0.01–0.41, <italic>p</italic>=0.003). Breastfeeding was marginally associated with an increased odds of perinatal transmission (aOR 4.52, 95% CI 0.78–26.17, <italic>p</italic> = 0.092). The attributable risk percentage for breastfeeding over the study period was 91.0%. Transmission decreased from 91 per 100 live births before 1997 to 2 per 100 in 2011 following the adoption of the prevention protocol.</p></sec><sec id="S5"><title>Conclusion</title><p id="P5">Transmission declined over the study period. The screening of pregnant women and timely initiation of prophylaxis and therapy are issues that require further attention.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9610933</journal-id><journal-id journal-id-type="pubmed-jr-id">20844</journal-id><journal-id journal-id-type="nlm-ta">Int J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Int. J. Infect. Dis.</journal-id><journal-title-group><journal-title>International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1201-9712</issn><issn pub-type="epub">1878-3511</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23791426</article-id><article-id pub-id-type="pmc">5463571</article-id><article-id pub-id-type="doi">10.1016/j.ijid.2013.04.015</article-id><article-id pub-id-type="manuscript">NIHMS862342</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Maternal risk factors for HIV infection in infants in northeastern Brazil</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>de Lemos</surname><given-names>Lígia M.D.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Lippi</surname><given-names>Joseph</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Rutherford</surname><given-names>George W.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Duarte</surname><given-names>Gabriella S.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Martins</surname><given-names>Nágyla G.R.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Santos</surname><given-names>Victor S.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Gurgel</surname><given-names>Ricardo Q.</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Nursing, Federal University of Sergipe, Aracaju, Sergipe, Brazil</aff><aff id="A2"><label>b</label>Global Health Sciences, University of California, San Francisco, California, USA</aff><aff id="A3"><label>c</label>Department of Medicine – Pediatrics, Federal University of Sergipe, Aracaju, Sergipe, Brazil</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author. <email>ligiadolce@gmail.com</email> (Lígia M.D. de Lemos)</corresp><fn id="FN2"><p><bold>Corresponding Editor:</bold> Eskild Petersen, Aarhus, Denmark</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>4</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>19</day><month>6</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>08</day><month>6</month><year>2017</year></pub-date><volume>17</volume><issue>10</issue><fpage>e913</fpage><lpage>e918</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.ijid.2013.04.015</pmc-comment>
<abstract><title>SUMMARY</title><sec id="S1"><title>Introduction</title><p id="P1">While the rate of vertically transmitted HIV infection has fallen in most regions of Brazil, there have been no similar decreases in northern and northeastern Brazil.</p></sec><sec id="S2"><title>Objective</title><p id="P2">The objective of this study was to evaluate the risk factors associated with vertical transmission in the state of Sergipe in northeastern Brazil.</p></sec><sec id="S3"><title>Methods</title><p id="P3">This was a retrospective cohort study. We recorded clinic and registry data for all HIV-infected pregnant women and exposed children diagnosed in Sergipe from 1990 to 2011.</p></sec><sec id="S4"><title>Results</title><p id="P4">We identified 538 deliveries and 561 HIV-exposed infants (23 sets of twins). One hundred one (18.9%) infants were HIV-infected. In the multivariate analysis, infant antiretroviral prophylaxis was a significant protective factor (adjusted odds ratio (aOR) 0.07, 95% confidence interval (CI) 0.01–0.41, <italic>p</italic>=0.003). Breastfeeding was marginally associated with an increased odds of perinatal transmission (aOR 4.52, 95% CI 0.78–26.17, <italic>p</italic> = 0.092). The attributable risk percentage for breastfeeding over the study period was 91.0%. Transmission decreased from 91 per 100 live births before 1997 to 2 per 100 in 2011 following the adoption of the prevention protocol.</p></sec><sec id="S5"><title>Conclusion</title><p id="P5">Transmission declined over the study period. The screening of pregnant women and timely initiation of prophylaxis and therapy are issues that require further attention.</p></sec></abstract><kwd-group><kwd>HIV</kwd><kwd>Vertical infectious disease transmission</kwd><kwd>Pregnancy</kwd><kwd>Breastfeeding</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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